| Identification |
|---|
| HMDB Protein ID
| CDBP02998 |
| Secondary Accession Numbers
| Not Available |
| Name
| Latrophilin-1 |
| Description
| Not Available |
| Synonyms
|
- CIRL-1
- Calcium-independent alpha-latrotoxin receptor 1
- Lectomedin-2
|
| Gene Name
| LPHN1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane receptor activity |
| Specific Function
| Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| binding |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| carbohydrate binding |
| sugar binding |
| Process |
| neuropeptide signaling pathway |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| LPHN1 |
| Gene Sequence
|
>4425 bp
ATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCG
GCCACCCAAGGCCTGAGCCGGGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCG
TGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAAT
GCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAAT
GTGCAGTGCTACCTGCCGGACGCCTTCAAGATCATGTCACAGAGGTGTAACAACCGCACC
CAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAG
TACCTGGAGGTGCAGTACGACTGTGTCCCCTACAAAGTGGAGCAGAAAGTCTTCGTGTGC
CCAGGGACCCTGCAGAAGGTGCTGGAGCCCACCTCGACACACGAGTCAGAGCACCAGTCT
GGCGCATGGTGCAAGGACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATC
CCCTACCGCACGGACACACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGC
CACACCACCACCTACCGCCTGCCCAACCGCGTGGATGGCACAGGCTTTGTGGTCTACGAT
GGTGCCGTCTTCTACAACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACG
CGCATCAAGAGCGGGGAGACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTAC
CGCTGGGGCGGAAAGACCGACATTGACCTGGCGGTGGACGAGAACGGGCTGTGGGTCATC
TACGCCACTGAGGGCAACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTG
CGCTTTGAGGGCACGTGGGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATG
GTGTGTGGGGTCCTGTACGTCCTGCGTTCCGTGTACGTGGATGATGACAGCGAGGCGGCT
GGCAACCGCGTGGACTATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTC
ACCTTCCCCAACCCCTACCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAG
CTGTACGTCTGGAACAACTATTTCGTGGTGCGCTACAGCCTGGAGTTCGGGCCGCCCGAC
CCCAGTGCTGGCCCAGCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACG
CCCCTCACCAGCACAGCCTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACC
ACGCACCCAGTGGGTGCCATCAACCAGCTGGGACCTGATCTGCCTCCAGCCACAGCCCCA
GTCCCCAGCACCCGGCGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGC
GAGCCCCGAGAGGTACGGCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAG
AGGCCCTGCCCCAAGGGGACTCGAGGAATTGCCTCCTTCCAGTGTCTACCAGCCTTGGGG
CTCTGGAACCCCCGGGGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTG
GCCCAGAAGATCAAGAGTGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACAC
ACCCGGGGCTCCATCTACGCGGGGGACGTCTCCTCCTCTGTGAAGCTGATGGAGCAGCTG
CTGGACATCCTGGATGCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGC
AAGAACTACAACAAGATGCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTG
GTGGAGACAGTGGACAATCTGCTCCGGCCAGAAGCTCTGGAGTCCTGGAAGGACATGAAT
GCCACGGAGCAGGTGCACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTC
CTGCTGGCCGACAATGTCAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTC
CTGGAGGTCACAGTCCTGAACACAGAGGGCCAGGTGCAGGAGCTGGTGTTCCCCCAGGAG
GAGTACCCGAGAAAGAACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGC
AATGGGGTGGTCAAAGTTGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACG
GAGAATGCCACAGTGAAGCTGGCCGGCGAAGCAGGCCCGGGTGGCCCTGGGGGCGCCTCT
CTAGTGGTGAACTCACAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTC
CTCATGGACCCTGTCATCTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCT
AACTGCTCCTTCTGGAACTACTCGGAGCGTTCCATGCTGGGCTACTGGTCGACCCAAGGC
TGCCGCCTGGTGGAGTCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAAC
TTCGCTGTGCTCATGGCTCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTG
TCGGTCATCACCTGGGTGGGCATTGTGATCTCCCTGGTCTGCTTGGCCATCTGCATCTCC
ACCTTCTGCTTCCTGCGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGC
ATCAACCTCTTCCTGGCTGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAG
ATTGCCTGCCCCATCTTCGCCGGCCTGCTGCACTATTTCTTCCTGGCTGCCTTCTCCTGG
CTGTGCCTGGAGGGCGTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTAT
TCCCGCACCAAGTACTACTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATC
GCGGCTGCCATTGACTACCGCAGCTACGGCACCGAGAAGGCCTGCTGGCTCCGAGTGGAC
AATTACTTCATCTGGAGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTG
TTCCTCATGGTGACCCTGCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCC
AGCCGCCTGGACAACATTAAATCCTGGGCGCTGGGGGCCATCGCGCTGCTGTTCCTGCTG
GGCCTCACCTGGGCTTTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTAT
CTCTTCACCACCTTCAACGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTA
CAGAAGAAGGTGCACAAGGAGTACAGCAAGTGCCTGCGTCACTCCTACTGCTGCATCCGC
TCCCCACCCGGGGGCACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGC
TACTACACAGGGACCCAGAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAG
ACGGAGTCCTCCTTCATGGCGGGTGACATCAACAGCACCCCCACCCTGAACCGAGGTACC
ATGGGGAACCACCTGCTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTAC
AACACCCTCATCGCCGAGTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCC
CCAGGGAGCTACCGGGAACCCAAGCACCCCTTGGGAGGCCGGGAAGCCTGTGGCATGGAC
ACCCTGCCCCTGAACGGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCT
CCCGGGGATGGGGGCCCTGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTT
GAGAAGATGATCATCTCAGAGCTGGTGCACAACAACCTGCGGGGGAGCAGCAGCGCGGCC
AAGGGCCCTCCACCGCCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAA
GAGGCGGGCGGGCCCGGGGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTG
GAGGAGCCTCTGCTGCTGCCCCGGGCCCAGTCGGTGCTGTACCAGAGCGATCTGGACGAG
TCGGAGAGCTGCACGGCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGC
CGGGACTCCCTCTATGCCAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGC
AGCCCTGAGGGGCCCAGTGAGGCCCTGCCCCCACCCCCTCCCGCACCCCCCGGCCCCCCC
GAAATCTACTACACCTCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTAC
TACCAGGTGCGGCGTCCTAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCA
GGGCCCGATGGGGACGGGCAGATGCAGCTGGTCACCAGTCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1474 |
| Molecular Weight
| 162715.4 |
| Theoretical pI
| 6.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["859-879", "894-914", "921-941", "965-985", "1003-1023", "1051-1071", "1076-1096"]
|
| Protein Sequence
|
>Latrophilin-1
MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVEN
ANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYK
YLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWI
PYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRT
RIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTL
RFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSL
TFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPT
PLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPSTRRPPAPNLHVSPELFC
EPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQV
AQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAG
KNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAF
LLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSR
NGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVF
LMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTN
FAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLC
INLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEY
SRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLV
FLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAY
LFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTR
YYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPY
NTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFP
PGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEE
EAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPG
RDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGY
YQVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL
|
| External Links |
|---|
| GenBank ID Protein
| 57165355 |
| UniProtKB/Swiss-Prot ID
| O94910 |
| UniProtKB/Swiss-Prot Entry Name
| LPHN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001008701.2 |
| GeneCard ID
| LPHN1 |
| GenAtlas ID
| LPHN1 |
| HGNC ID
| HGNC:20973 |
| References |
|---|
| General References
| Not Available |