Identification
HMDB Protein ID CDBP02992
Secondary Accession Numbers Not Available
Name Protein lin-7 homolog C
Description Not Available
Synonyms
  1. Lin-7C
  2. MALS-3
  3. Mammalian lin-seven protein 3
  4. Veli-3
  5. Vertebrate lin-7 homolog 3
Gene Name LIN7C
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells
GO Classification
Function
binding
protein binding
Cellular Location
  1. Cell membrane
  2. Peripheral membrane protein
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Basolateral cell membrane
  6. Cell junction
  7. Cell junction
  8. Cell junction
  9. Cell junction
  10. synapse
  11. synapse
  12. tight junction
  13. postsynaptic cell membrane
  14. postsynaptic density
  15. synaptosome
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11p14
SNPs LIN7C
Gene Sequence
>594 bp
ATGGCGGCGCTAGGGGAACCCGTGCGGCTGGAGAGAGATATTTGTAGAGCAATTGAATTA
TTGGAAAAACTACAAAGGAGTGGAGAAGTACCACCACAGAAACTTCAGGCTTTGCAAAGA
GTCCTTCAAAGTGAATTCTGCAATGCTGTGAGAGAGGTATATGAACATGTCTATGAGACT
GTGGACATCAGTAGCAGTCCTGAAGTGAGAGCGAACGCTACTGCAAAGGCTACTGTTGCT
GCATTTGCTGCCAGTGAAGGACATTCTCATCCTCGAGTTGTTGAGCTACCAAAAACAGAA
GAGGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAACTCTCCAATCTATATATCC
CGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCTCAAACGTGGAGATCAACTC
CTCTCTGTTAATGGAGTGAGTGTTGAAGGAGAACATCATGAAAAAGCTGTAGAACTGCTG
AAAGCCGCACAAGGAAAGGTTAAATTAGTGGTACGATACACACCCAAAGTCTTAGAAGAA
ATGGAGTCGCGCTTTGAAAAAATGAGATCAGCAAAACGCAGGCAACAGACCTAA
Protein Properties
Number of Residues 197
Molecular Weight 21833.8
Theoretical pI 8.7
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Protein lin-7 homolog C
MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET
VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS
RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE
MESRFEKMRSAKRRQQT
GenBank ID Protein 7023741
UniProtKB/Swiss-Prot ID Q9NUP9
UniProtKB/Swiss-Prot Entry Name LIN7C_HUMAN
PDB IDs Not Available
GenBank Gene ID AK002077
GeneCard ID LIN7C
GenAtlas ID LIN7C
HGNC ID HGNC:17789
References
General References Not Available