Identification |
HMDB Protein ID
| CDBP02992 |
Secondary Accession Numbers
| Not Available |
Name
| Protein lin-7 homolog C |
Description
| Not Available |
Synonyms
|
- Lin-7C
- MALS-3
- Mammalian lin-seven protein 3
- Veli-3
- Vertebrate lin-7 homolog 3
|
Gene Name
| LIN7C |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein binding |
Specific Function
| Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells |
GO Classification
|
Function |
binding |
protein binding |
|
Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Peripheral membrane protein
- Basolateral cell membrane
- Cell junction
- Cell junction
- Cell junction
- Cell junction
- synapse
- synapse
- tight junction
- postsynaptic cell membrane
- postsynaptic density
- synaptosome
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 11p14 |
SNPs
| LIN7C |
Gene Sequence
|
>594 bp
ATGGCGGCGCTAGGGGAACCCGTGCGGCTGGAGAGAGATATTTGTAGAGCAATTGAATTA
TTGGAAAAACTACAAAGGAGTGGAGAAGTACCACCACAGAAACTTCAGGCTTTGCAAAGA
GTCCTTCAAAGTGAATTCTGCAATGCTGTGAGAGAGGTATATGAACATGTCTATGAGACT
GTGGACATCAGTAGCAGTCCTGAAGTGAGAGCGAACGCTACTGCAAAGGCTACTGTTGCT
GCATTTGCTGCCAGTGAAGGACATTCTCATCCTCGAGTTGTTGAGCTACCAAAAACAGAA
GAGGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAACTCTCCAATCTATATATCC
CGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCTCAAACGTGGAGATCAACTC
CTCTCTGTTAATGGAGTGAGTGTTGAAGGAGAACATCATGAAAAAGCTGTAGAACTGCTG
AAAGCCGCACAAGGAAAGGTTAAATTAGTGGTACGATACACACCCAAAGTCTTAGAAGAA
ATGGAGTCGCGCTTTGAAAAAATGAGATCAGCAAAACGCAGGCAACAGACCTAA
|
Protein Properties |
Number of Residues
| 197 |
Molecular Weight
| 21833.8 |
Theoretical pI
| 8.7 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Protein lin-7 homolog C
MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET
VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS
RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE
MESRFEKMRSAKRRQQT
|
External Links |
GenBank ID Protein
| 7023741 |
UniProtKB/Swiss-Prot ID
| Q9NUP9 |
UniProtKB/Swiss-Prot Entry Name
| LIN7C_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK002077 |
GeneCard ID
| LIN7C |
GenAtlas ID
| LIN7C |
HGNC ID
| HGNC:17789 |
References |
General References
| Not Available |