Showing Protein Protein lin-7 homolog B (CDBP02991)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02991
Secondary Accession Numbers Not Available
Name Protein lin-7 homolog B
Description Not Available
Synonyms
  1. Lin-7B
  2. MALS-2
  3. Mammalian lin-seven protein 2
  4. Veli-2
  5. Vertebrate lin-7 homolog 2
  6. hLin7B
  7. hVeli2
Gene Name LIN7B
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface
GO Classification
Function
binding
protein binding
Cellular Location
  1. Cell membrane
  2. Peripheral membrane protein
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Basolateral cell membrane
  6. Cell junction
  7. Cell junction
  8. Cell junction
  9. Cell junction
  10. synapse
  11. synapse
  12. tight junction
  13. postsynaptic cell membrane
  14. postsynaptic density
  15. synaptosome
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.3
SNPs LIN7B
Gene Sequence 
>624 bp
ATGGCTGCGCTGGTGGAGCCGCTGGGGCTGGAGCGGGACGTGTCCCGGGCGGTTGAGCTC
CTCGAGCGGCTCCAGCGCAGCGGGGAGCTGCCGCCGCAGAAGCTGCAGGCCCTCCAGCGA
GTTCTGCAGAGCCGCTTCTGCTCCGCTATCCGAGAGGTGTATGAGCAGCTTTATGACACG
CTGGACATCACCGGCAGCGCCGAGATCCGAGCCCATGCCACAGCCAAGGCCACAGTGGCT
GCCTTCACAGCCAGCGAGGGCCACGCACATCCCAGGGTAGTGGAGCTACCCAAGACGGAT
GAGGGCCTAGGCTTCAACATCATGGGTGGCAAAGAGCAAAACTCGCCCATCTACATCTCC
CGGGTCATCCCAGGGGGTGTGGCTGACCGCCATGGAGGCCTCAAGCGTGGGGATCAACTG
TTGTCGGTGAACGGTGTGAGCGTTGAGGGTGAGCAGCATGAGAAGGCGGTGGAGCTGCTG
AAGGCGGCCCAGGGCTCGGTGAAGCTGGTTGTCCGTTACACACCGCGAGTGCTGGAGGAG
ATGGAGGCCCGGTTCGAGAAGATGCGCTCTGCCCGCCGGCGCCAACAGCATCAGAGCTAC
TCGTCCTTGGAGTCTCGAGGTTGA
Protein Properties
Number of Residues 207
Molecular Weight 22895.9
Theoretical pI 9.01
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Protein lin-7 homolog B
MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT
LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS
RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE
MEARFEKMRSARRRQQHQSYSSLESRG
GenBank ID Protein 11321325
UniProtKB/Swiss-Prot ID Q9HAP6
UniProtKB/Swiss-Prot Entry Name LIN7B_HUMAN
PDB IDs
GenBank Gene ID AF311862
GeneCard ID LIN7B
GenAtlas ID LIN7B
HGNC ID HGNC:17788
References
General References Not Available