| Identification |
|---|
| HMDB Protein ID
| CDBP02990 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lck-interacting transmembrane adapter 1 |
| Description
| Not Available |
| Synonyms
|
- Lck-interacting membrane protein
- Lck-interacting molecule
|
| Gene Name
| LIME1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Single-pass type III membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q13.3 |
| SNPs
| LIME1 |
| Gene Sequence
|
>888 bp
ATGGGGCTGCCAGTGTCCTGGGCCCCTCCTGCCCTCTGGGTTCTAGGGTGCTGCGCCCTG
CTCCTCTCGCTGTGGGCGCTGTGCACAGCCTGCCGCAGGCCCGAGGACGCTGTAGCCCCC
AGGAAGAGGGCGCGGAGGCAGCGGGCGAGGCTGCAGGGCAGTGCGACGGCGGCGGAAGCG
TCCCTACTGAGGCGGACCCACCTCTGCTCCCTCAGCAAGTCGGACACCAGACTGCACGAG
CTGCACCGGGGCCCGCGCAGCAGCAGGGCCCTGCGGCCTGCCAGCATGGATCTCCTGCGC
CCACACTGGCTGGAGGTGTCCAGGGACATCACCGGACCGCAGGCAGCCCCCTCTGCCTTC
CCACACCAGGAGCTGCCCCGGGCTCTGCCGGCAGCTGCAGCCACCGCAGGGTGCGCTGGC
CTCGAGGCCACCTATTCCAACGTGGGGCTGGCGGCCCTTCCCGGGGTCAGCCTGGCGGCC
AGCCCTGTGGTGGCCGAGTATGCCCGCGTCCAGAAGCGCAAAGGGACCCATCGCAGTCCC
CAAGAGCCACAGCAGGGGAAGACTGAGGTGACCCCGGCCGCTCAGGTGGACGTCCTGTAC
TCCAGGGTCTGCAAGCCTAAAAGGAGGGACCCAGGACCCACCACAGACCCGCTGGACCCC
AAGGGCCAGGGAGCGATTCTGGCCCTGGCGGGTGACCTGGCCTACCAGACCCTCCCGCTC
AGGGCCCTGGATGTGGGCAGCGGCCCCCTGGAAAACGTGTATGAGAGCATCCGGGAGCTG
GGGGACCCTGCTGGCAGGAGCAGCACGTGCGGGGCTGGGACGCCCCCTGCTTCCAGCTGC
CCCAGCCTAGGGAGGGGCTGGAGACCCCTCCCTGCCTCCCTGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 31287.4 |
| Theoretical pI
| 9.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lck-interacting transmembrane adapter 1
MGLPVSWAPPALWVLGCCALLLSLWALCTACRRPEDAVAPRKRARRQRARLQGSATAAEA
SLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWLEVSRDITGPQAAPSAF
PHQELPRALPAAAATAGCAGLEATYSNVGLAALPGVSLAASPVVAEYARVQKRKGTHRSP
QEPQQGKTEVTPAAQVDVLYSRVCKPKRRDPGPTTDPLDPKGQGAILALAGDLAYQTLPL
RALDVDSGPLENVYESIRELGDPAGRSSTCGAGTPPASSCPSLGRGWRPLPASLP
|
| External Links |
|---|
| GenBank ID Protein
| 7020485 |
| UniProtKB/Swiss-Prot ID
| Q9H400 |
| UniProtKB/Swiss-Prot Entry Name
| LIME1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK000413 |
| GeneCard ID
| LIME1 |
| GenAtlas ID
| LIME1 |
| HGNC ID
| HGNC:26016 |
| References |
|---|
| General References
| Not Available |