| Identification |
|---|
| HMDB Protein ID
| CDBP02985 |
| Secondary Accession Numbers
| Not Available |
| Name
| Linker for activation of T-cells family member 1 |
| Description
| Not Available |
| Synonyms
|
- 36 kDa phospho-tyrosine adapter protein
- p36-38
- pp36
|
| Gene Name
| LAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transduction |
| Specific Function
| Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Process |
| signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
|
| Cellular Location
|
- Cell membrane
- Single-pass type III membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fc Epsilon Receptor I Signaling in Mast Cells |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p11.2 |
| SNPs
| LAT |
| Gene Sequence
|
>789 bp
ATGGAGGAGGCCATCCTGGTCCCCTGCGTGCTGGGGCTCCTGCTGCTGCCCATCCTGGCC
ATGTTGATGGCACTGTGTGTGCACTGCCACAGACTGCCAGGCTCCTACGACAGCACATCC
TCAGATAGTTTGTATCCAAGGGGCATCCAGTTCAAACGGCCTCACACGGTTGCCCCCTGG
CCACCTGCCTACCCACCTGTCACCTCCTACCCACCCCTGAGCCAGCCAGACCTGCTCCCC
ATCCCAAGATCCCCGCAGCCCCTTGGGGGCTCCCACCGGACGCCATCTTCCCGGCGGGAT
TCTGATGGTGCCAACAGTGTGGCGAGCTACGAGAACGAGGGTGCGTCTGGGATCCGAGGT
GCCCAGGCTGGGTGGGGAGTCTGGGGTCCGTCCTGGACTAGGCTGACCCCTGTGTCGTTA
CCCCCAGAACCAGCCTGTGAGGATGCGGATGAGGATGAGGACGACTATCACAACCCAGGC
TACCTGGTGGTGCTTCCTGACAGCACCCCGGCCACTAGCACTGCTGCCCCATCAGCTCCT
GCACTCAGCACCCCTGGCATCCGAGACAGTGCCTTCTCCATGGAGTCCATTGATGATTAC
GTGAACGTTCCGGAGAGCGGGGAGAGCGCAGAAGCGTCTCTGGATGGCAGCCGGGAGTAT
GTGAATGTGTCCCAGGAACTGCATCCTGGAGCGGCTAAGACTGAGCCTGCCGCCCTGAGT
TCCCAGGAGGCAGAGGAAGTGGAGGAAGAGGGGGCTCCAGATTACGAGAATCTGCAGGAG
CTGAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 262 |
| Molecular Weight
| 27929.4 |
| Theoretical pI
| 4.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Linker for activation of T-cells family member 1
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPW
PPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRG
AQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAP
ALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALS
SQEAEEVEEEGAPDYENLQELN
|
| External Links |
|---|
| GenBank ID Protein
| 7657293 |
| UniProtKB/Swiss-Prot ID
| O43561 |
| UniProtKB/Swiss-Prot Entry Name
| LAT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014387.3 |
| GeneCard ID
| LAT |
| GenAtlas ID
| LAT |
| HGNC ID
| HGNC:18874 |
| References |
|---|
| General References
| Not Available |