| Identification |
|---|
| HMDB Protein ID
| CDBP02971 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-activated potassium channel subunit beta-4 |
| Description
| Not Available |
| Synonyms
|
- BK channel subunit beta-4
- BKbeta4
- Calcium-activated potassium channel, subfamily M subunit beta-4
- Charybdotoxin receptor subunit beta-4
- Hbeta4
- K(VCA)beta-4
- Maxi K channel subunit beta-4
- Slo-beta-4
|
| Gene Name
| KCNMB4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in calcium-activated potassium channel activity |
| Specific Function
| Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| calcium activated cation channel activity |
| calcium-activated potassium channel activity |
| transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q |
| SNPs
| KCNMB4 |
| Gene Sequence
|
>633 bp
ATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTC
GGCTTGTTTCTCATCATCTCCGGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTG
AGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTGTCGGTGCAG
CAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCG
CAGTACCCCTGCGTCCAGGTCTACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTG
CACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGTGCTCCTATATCCCTCCCTGTAAG
AGAGAAAATCAGAAGAATTTGGAAAGTGTCATGAATTGGCAACAGTACTGGAAAGATGAG
ATTGGTTCCCAGCCATTTACTTGCTATTTTAATCAACATCAAAGACCAGATGATGTGCTT
CTGCATCGCACTCATGATGAGATTGTCCTCCTGCATTGCTTCCTCTGGCCCCTGGTGACA
TTTGTGGTGGGCGTTCTCATTGTGGTCCTGACCATCTGTGCCAAGAGCTTGGCGATCAAG
GCGGAAGCCATGAAGAAGCGCAAGTTCTCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 210 |
| Molecular Weight
| 23948.5 |
| Theoretical pI
| 6.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-activated potassium channel subunit beta-4
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQ
QIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCK
RENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVT
FVVGVLIVVLTICAKSLAVKAEAMKKRKFS
|
| External Links |
|---|
| GenBank ID Protein
| 7799988 |
| UniProtKB/Swiss-Prot ID
| Q86W47 |
| UniProtKB/Swiss-Prot Entry Name
| KCMB4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF160967 |
| GeneCard ID
| KCNMB4 |
| GenAtlas ID
| KCNMB4 |
| HGNC ID
| HGNC:6289 |
| References |
|---|
| General References
| Not Available |