| Identification |
|---|
| HMDB Protein ID
| CDBP02968 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-activated potassium channel subunit beta-1 |
| Description
| Not Available |
| Synonyms
|
- BK channel subunit beta-1
- BKbeta
- BKbeta1
- Calcium-activated potassium channel subunit beta
- Calcium-activated potassium channel, subfamily M subunit beta-1
- Charybdotoxin receptor subunit beta-1
- Hbeta1
- K(VCA)beta-1
- Maxi K channel subunit beta-1
- Slo-beta
- Slo-beta-1
|
| Gene Name
| KCNMB1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in calcium-activated potassium channel activity |
| Specific Function
| Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| calcium activated cation channel activity |
| calcium-activated potassium channel activity |
| transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q34 |
| SNPs
| KCNMB1 |
| Gene Sequence
|
>576 bp
ATGGTGAAGAAGCTGGTGATGGCCCAGAAGCGGGGAGAGACACGAGCCCTTTGCCTGGGT
GTAACCATGGTGGTGTGTGCCGTCATCACCTACTACATCCTGGTCACGACTGTGCTGCCC
CTCTACCAGAAAAGCGTGTGGACCCAGGAATCCAAGTGCCACCTGATTGAGACCAACATC
AGGGACCAGGAGGAGCTGAAGGGCAAGAAGGTGCCCCAGTACCCATGCCTGTGGGTCAAC
GTGTCAGCTGCCGGCAGGTGGGCTGTGCTGTACCACACGGAGGACACTCGGGACCAGAAC
CAGCAGTGCTCCTACATCCCAGGCAGCGTGGACAATTACCAGACGGCCCGGGCCGACGTG
GAGAAGGTCAGAGCCAAATTCCAAGAGCAGCAGGTCTTCTACTGCTTCTCCGCACCTCGG
GGGAACGAAACCAGCGTCCTATTCCAGCGCCTCTACGGGCCCCAGGCCCTCCTCTTCTCC
CTCTTCTGGCCCACCTTCCTGCTGACCGGTGGCCTCCTCATTATCGCCATGGTGAAGAGC
AACCAGTACCTGTCCATCCTGGCGGCCCAGAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 191 |
| Molecular Weight
| 21797.3 |
| Theoretical pI
| 9.16 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-activated potassium channel subunit beta-1
MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNI
RDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADV
EKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKS
NQYLSILAAQK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q16558 |
| UniProtKB/Swiss-Prot Entry Name
| KCMB1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U25138 |
| GeneCard ID
| KCNMB1 |
| GenAtlas ID
| KCNMB1 |
| HGNC ID
| HGNC:6285 |
| References |
|---|
| General References
| Not Available |