| Identification |
|---|
| HMDB Protein ID
| CDBP02954 |
| Secondary Accession Numbers
| Not Available |
| Name
| Immunoglobulin superfamily member 2 |
| Description
| Not Available |
| Synonyms
|
- CD101 antigen
- Cell surface glycoprotein V7
- EWI-101
- Glu-Trp-Ile EWI motif-containing protein 101
- IgSF2
|
| Gene Name
| CD101 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| Specific Function
| Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells |
| GO Classification
|
| Function |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p13 |
| SNPs
| CD101 |
| Gene Sequence
|
>3066 bp
ATGGCAGGCATCTCATATGTGGCATCTTTCTTTCTCCTTCTGACTAAGCTCAGCATTGGC
CAGAGAGAAGTAACAGTTCAGAAAGGACCACTGTTTAGAGCTGAAGGTTACCCAGTCAGC
ATTGGCTGCAATGTAACTGGCCACCAGGGACCTTCTGAGCAGCATTTCCAGTGGTCTGTT
TACCTGCCGACAAACCCGACCCAGGAAGTCCAGATCATTAGCACCAAGGATGCTGCCTTC
TCTTACGCAGTATATACGCAGCGGGTGCGAAGCGGAGACGTCTACGTGGAGAGGGTCCAG
GGCAACTCAGTCTTGTTGCACATCTCAAAACTCCAGATGAAGGATGCTGGCGAGTATGAG
TGTCACACACCAAACACTGATGAGAAATACTATGGAAGTTACAGTGCAAAGACTAATCTA
ATTGTTATTCCAGATACCCTCTCTGCCACCATGAGTTCTCAGACTCTCGGTAAGGAGGAA
GGTGAGCCATTAGCCCTCACCTGTGAGGCATCCAAAGCCACAGCCCAACATACTCACCTC
TCTGTCACCTGGTACCTAACACAGGATGGAGGAGGAAGCCAAGCCACTGAGATTATTTCT
CTCTCCAAAGATTTTATATTGGTCCCTGGGCCCTTGTATACAGAGCGGTTTGCAGCCAGT
GACGTACAGCTCAACAAACTGGGACCCACTACATTCAGGCTGTCCATAGAGAGGCTCCAG
TCCTCAGATCAGGGTCAGCTGTTCTGTGAGGCAACGGAATGGATTCAGGATCCAGATGAA
ACTTGGATGTTCATCACCAAAAAGCAGACCGATCAAACCACTCTGAGGATCCAGCCAGCA
GTGAAAGATTTTCAAGTCAACATTACAGCTGACAGCTTGTTTGCTGAAGGGAAACCCTTA
GAACTGGTTTGCCTGGTTGTAAGCAGTGGCCGTGACCCACAGCTTCAAGGCATTTGGTTC
TTCAATGGGACTGAAATTGCTCACATTGATGCTGGTGGAGTCCTGGGCCTGAAGAATGAC
TACAAAGAGAGAGCAAGTCAAGGAGAGCTCCAGGTTTCAAAGTTAGGCCCCAAGGCTTTC
TCTCTCAAGATCTTCTCTCTGGGCCCAGAGGATGAAGGCGCCTACAGATGTGTGGTAGCA
GAGGTCATGAAAACACGCACAGGTTCCTGGCAGGTGCTTCAGAGAAAGCAGTCACCAGAC
AGCCACGTGCACCTGAGGAAGCCAGCAGCAAGAAGTGTGGTCATGTCTACCAAGAACAAG
CAGCAAGTTGTGTGGGAAGGAGAGACACTCGCCTTTCTCTGTAAGGCTGGTGGAGCTGAA
AGTCCCCTGTCTGTGAGCTGGTGGCACATCCCACGGGACCAGACACAGCCCGAGTTTGTG
GCTGGCATGGGGCAGGATGGCATTGTGCAGCTGGGTGCCTCCTATGGGGTACCCAGTTAC
CATGGCAACACAAGGCTGGAGAAAATGGACTGGGCCACCTTCCAGCTGGAGATCACCTTC
ACTGCCATCACAGACAGTGGCACATATGAGTGCAGAGTATCTGAGAAGTCTCGGAACCAG
GCCAGAGATCTGAGCTGGACTCAGAAGATTTCAGTTACTGTAAAGTCTCTGGAGTCAAGT
TTACAAGTTAGTCTGATGAGCCGTCAGCCGCAAGTGATGTTAACCAACACCTTTGACCTG
TCCTGTGTCGTGAGGGCCGGTTACTCTGACCTCAAGGTGCCACTCACTGTGACGTGGCAG
TTCCAGCCAGCTAGCTCTCACATCTTCCACCAGCTTATTCGAATCACCCACAATGGCACT
ATTGAATGGGGGAATTTCCTATCCCGGTTCCAAAAGAAGACGAAAGTGTCGCAGTCTTTA
TTTCGTTCACAACTCCTAGTCCATGATGCCACTGAGGAAGAGACAGGAGTGTATCAGTGT
GAAGTAGAAGTTTATGACAGAAATTCCCTATACAACAACCGCCCCCCGAGGGCTTCTGCC
ATCTCTCACCCACTGAGGATAGCCGTCACTTTACCAGAGAGCAAGCTAAAAGTGAATTCA
AGGAGTCAAGTCCAAGAGCTCTCCATCAACTCCAACACTGATATAGAATGTAGCATCTTG
TCCCGGTCCAATGGAAACCTTCAGTTAGCCATTATTTGGTATTTTTCTCCTGTTTCCACT
AATGCCTCTTGGCTAAAGATCCTGGAGATGGACCAAACCAATGTTATAAAAACTGGGGAT
GAGTTTCACACCCCACAGAGAAAACAAAAATTTCATACTGAGAAGGTTTCCCAAGACTTA
TTTCAGCTGCACATTCTGAATGTGGAAGACAGCGATCGGGGCAAATATCACTGTGCTGTG
GAGGAATGGCTCCTGTCTACAAATGGCACTTGGCACAAGCTTGGAGAAAAGAAGTCAGGA
CTAACAGAATTGAAACTCAAGCCCACAGGAAGTAAGGTACGTGTCTCCAAAGTGTACTGG
ACCGAAAATGTGACTGAGCACAGAGAAGTGGCCATCCGCTGCAGCCTGGAGAGTGTAGGC
AGCTCAGCCACTCTGTACTCTGTGATGTGGTACTGGAACAGAGAAAACTCTGGAAGTAAA
TTGCTGGTGCACTTGCAACATGATGGCTTGCTGGAGTATGGGGAAGAGGGGCTCAGGAGG
CACCTGCACTGTTACCGTTCATCCTCTACAGACTTTGTCCTGAAGCTTCATCAGGTGGAG
ATGGAGGATGCAGGAATGTACTGGTGTAGGGTGGCAGAGTGGCAGCTCCATGGACACCCA
AGCAAGTGGATTAATCAAGCATCCGATGAGTCACAGCGGATGGTGCTCACGGTGCTGCCT
TCAGAGCCCACGCTTCCTTCCAGGATCTGCTCCTCGGCCCCTTTACTCTATTTCCTGTTC
ATCTGTCCCTTCGTCCTGCTCCTCCTTCTGCTCATCTCCCTCCTCTGCTTATACTGGAAG
GCCAGGAAGTTGTCAACACTGCGTTCCAACACACGGAAAGAAAAAGCTCTCTGGGTGGAC
TTGAAAGAGGCTGGAGGTGTGACCACAAATAGGAGGGAAGACGAGGAGGAAGATGAAGGC
AACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1021 |
| Molecular Weight
| 115107.7 |
| Theoretical pI
| 6.96 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Immunoglobulin superfamily member 2
MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSV
YLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYE
CHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHL
SVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQ
SSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPL
ELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAF
SLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNK
QQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSY
HGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESS
LQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGT
IEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASA
ISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVST
NASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAV
EEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVG
SSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVE
MEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLF
ICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEG
N
|
| External Links |
|---|
| GenBank ID Protein
| 55665019 |
| UniProtKB/Swiss-Prot ID
| Q93033 |
| UniProtKB/Swiss-Prot Entry Name
| IGSF2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL445231 |
| GeneCard ID
| CD101 |
| GenAtlas ID
| CD101 |
| HGNC ID
| HGNC:5949 |
| References |
|---|
| General References
| Not Available |