Identification
HMDB Protein ID CDBP02952
Secondary Accession Numbers Not Available
Name Inhibitor of Bruton tyrosine kinase
Description Not Available
Synonyms
  1. IBtk
Gene Name IBTK
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription
GO Classification
Function
binding
protein binding
Cellular Location
  1. Isoform 2:Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:6
Locus 6q14.1
SNPs IBTK
Gene Sequence
>4062 bp
ATGAGTTCACCCATGCCTGACTGCACATCAAAGTGTCGATCCCTGAAGCATGCTTTGGAT
GTCCTTTCTGTGGTAACAAAGGGGAGCGAAAACCAGATTAAGGCCTTTCTCTCCAGTCAT
TGTTACAATGCTGCAACTATCAAGGATGTTTTTGGCAGGAATGCCCTCCACCTTGTTTCC
TCCTGTGGAAAGAAAGGAGTGTTAGATTGGCTTATTCAGAAAGGAGTGGATCTGTTGGTG
AAAGACAAAGAGTCTGGATGGACAGCATTGCACAGAAGCATTTTTTATGGACATATTGAT
TGTGTTTGGTCTCTATTGAAGCATGGTGTTAGTCTGTATATTCAAGATAAAGAAGGCTTG
TCAGCTTTGGATCTTGTAATGAAGGATAGACCAACTCATGTAGTATTCAAGAATACTGAT
CCTACAGATGTTTATACTTGGGGCGATAATACAAATTTTACCCTGGGTCATGGAAGCCAG
AATAGCAAACATCATCCAGAGTTGGTGGATCTGTTCTCCAGGAGTGGGATTTATATCAAG
CAGGTGGTGCTTTGTAAATTTCACTCCGTGTTTCTGTCTCAGAAAGGGCAGGTTTATACC
TGTGGTCATGGTCCTGGAGGGCGATTAGGACATGGAGATGAACAGACATGCTTGGTCCCT
CGGCTTGTGGAAGGACTGAATGGTCATAATTGTTCCCAAGTGGCAGCTGCTAAGGATCAT
ACTGTTGTATTAACTGAAGATGGATGTGTTTATACATTTGGTCTAAACATTTTTCATCAA
TTAGGAATTATTCCACCGCCTTCCAGTTGTAATGTACCCAGACAGATACAGGCAAAATAT
CTGAAAGGAAGGACAATCATTGGCGTTGCAGCAGGCAGGTTTCATACAGTCCTATGGACT
AGAGAAGCTGTTTACACTATGGGACTAAATGGTGGACAACTGGGTTGTTTGCTAGATCCC
AATGGAGAAAAGTGTGTAACTGCTCCTCGTCAGGTCTCTGCCCTTCACCATAAAGACATT
GCTCTGTCTTTGGTTGCTGCAAGTGATGGAGCTACAGTCTGTGTTACCACAAGGGGAGAT
ATTTACTTACTTGCAGACTATCAGTGCAAGAAGATGGCTTCTAAACAGTTGAACTTGAAA
AAAGTTCTTGTGTCTGGGGGTCATATGGAATACAAGGTTGATCCTGAACATTTGAAAGAA
AATGGGGGTCAAAAAATTTGCATTCTTGCAATGGATGGAGCTGGAAGGGTGTTTTGCTGG
AGATCAGTCAACAGTTCTCTGAAGCAGTGTCGATGGGCCTATCCACGTCAGGTCTTCATT
TCTGATATTGCTTTAAATAGAAATGAAATTCTATTTGTTACGCAAGATGGAGAAGGATTT
AGAGGGAGATGGTTTGAAGAGAAAAGAAAGAGTTCTGAAAAGAAAGAGATTTTATCAAAC
CTTCACAATTCCTCATCAGATGTGTCTTATGTCTCTGATATAAATAGTGTGTATGAAAGA
ATTCGACTTGAGAAACTTACCTTTGCACATAGAGCTGTTAGTGTCAGCACAGATCCAAGT
GGATGCAACTTTGCAATCCTGCAGTCAGATCCTAAAACAAGCCTTTATGAAATTCCAGCT
GTGTCCTCATCATCCTTTTTTGAAGAGTTTGGCAAACTGTTGAGGGAAGCAGATGAAATG
GACAGCATTCATGATGTGACATTTCAAGTTGGCAATAGACTCTTCCCTGCACATAAATAT
ATTTTGGCAGTGCATTCTGATTTTTTTCAGAAATTGTTTCTTTCAGATGGTAATACTTCA
GAATTTACAGATATTTACCAGAAAGATGAAGATTCTGCAGGGTGCCATCTCTTTGTGGTA
GAGAAGGTTCATCCTGACATGTTTGAATACCTTTTACAATTTATATACACAGATACTTGT
GACTTTTTAACTCATGGCTTCAAACCAAGAATACACTTAAACAAAAACCCAGAAGAATAT
CAGGGAACTCTGAATTCTCATTTGAATAAAGTGAATTTCCATGAAGATGATAACCAGAAG
TCTGCATTTGAAGTTTACAAAAGTAATCAAGCTCAAACAGTTAGTGAGAGGCAGAAGAGC
AAACCTAAATCTTGTAAAAAAGGAAAAAATATTAGGGAAGATGATCCTGTAAGAATGTTG
CAAACTGTTGCAAAGAAATTCGACTTCAGTAATTTGAGTAGTAGGTTAGATGGAGTCAGA
TTTGAAAATGAAAAAATTAATGTTATTGCCAAGAACACTGGTAATAAACTGAAGCTAAGT
CAGAAAAAATGTTCATTTCTGTGTGACGTGACCATGAAATCAGTGGATGGAAAGGAATTT
CCTTGTCATAAATGTGTTCTTTGTGCTAGACTTGAATATTTTCATAGTATGCTGAGTAGC
TCATGGATTGAGGCTTCCAGTTGTGCAGCTCTGGAAATGCCAATACATTCTGATATATTA
AAAGTTATTTTGGACTACCTCTATACTGATGAAGCTGTGGTGATAAAAGAATCTCAAAAT
GTAGATTTTATTTGTAGTGTTCTTGTGGTGGCTGATCAACTTCTCATAACCCGGTTGAAA
GAGATTTGTGAAGTAGCATTAACTGAAAAACTTACCCTGAAGAATGCTGCTATGCTACTG
GAATTTGCAGCAATGTATAGTGCAAAACAGTTGAAACTGTCTTGTTTACAGTTTATAGGA
TTGAATATGGCAGCTTTACTTGAAGCAAGGTCTCTTGATGTTTTAAGCGATGGTGTTTTG
AAGGATCTTTCTGAGTTTTACCGGAAAATGATTCCAGCAATGGATAGAAGAGTCATTACA
CCATATCAAGATGGACCAGATATTAGCTATTTGGAAGTAGAAGATGGAGATATCTTCTTG
AAAGAAGAAATAAATATGGAACAAAATCATTCGGAAACTATGTTCAAGAAAGCAAAAACA
AAAGCTAAAAAGAAGCCACGTAAACGTTCAGATAGTTCTGGAGGTTATAACCTTTCAGAT
ATTATTCAGAGTCCATCATCTACAGGATTATTAAAGTCTGGTAAGACCAATTCTGTGGAA
TCTCTTCCAGAACTGTTGACATCAGACTCTGAAGGAAGCTATGCAGGAGTGGGTAGTCCT
AGAGATTTACAGTCCCCTGATTTCACAACAGGATTTCATTCAGATAAGATTGAGGCGAAA
GTCAAACCGTATGTTAATGGTACATCTCCTGTGTATTCTAGGGAAGATTTAAAACCATGG
GAAAAGTCACCAATACTTAAAATATCTGCTCCACAGCCTATTCCCAGTAACAGAATTGAT
ACTACCAGCTCTGCCAGTTGGGTTGCTGGTTCTTTCAGTCCTGTCAGCCCTCCTGTTGTG
GATCTCAGAACTATCATGGAAATAGAAGAAAGTAGACAAAAATGTGGAGCTACACCAAAG
TCACATTTAGGCAAAACAGTTTCTCATGGAGTTAAACTTTCTCAGAAGCAACGAAAAATG
ATTGCATTGACTACCAAGGAAAACAATTCAGGAATGAATAGCATGGAAACAGTTTTATTC
ACTCCTTCAAAAGCCCCCAAACCAGTGAATGCATGGGCATCTTCTCTGCATTCAGTTTCA
TCCAAGTCATTCCGGGATTTCTTACTAGAAGAAAAAAAGTCTGTTACTAGCCATAGTTCA
GGCGATCATGTCAAAAAAGTTTCTTTTAAAGGAATTGAAAATTCTCAGGCACCAAAAATT
GTCAGATGCTCTACCCATGGTACCCCAGGACCAGAAGGCAACCATATTTCAGATTTACCA
CTTCTAGACAGTCCCAATCCCTGGCTATCTTCTTCAGTGACTGCTCCATCCATGGTAGCC
CCAGTCACTTTTGCATCTATTGTAGAAGAAGAACTACAACAAGAAGCAGCTCTTATTAGA
AGTCGAGAAAAACCGTTGGCTCTGATTCAGATTGAGGAGCATGCCATACAAGATTTATTG
GTTTTCTATGAGGCATTTGGCAACCCTGAAGAGTTTGTCATTGTTGAAAGGACACCGCAG
GGACCACTGGCAGTACCTATGTGGAATAAGCATGGATGCTAG
Protein Properties
Number of Residues 1353
Molecular Weight 150526.6
Theoretical pI 7.75
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Inhibitor of Bruton tyrosine kinase
MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
GenBank ID Protein 57863304
UniProtKB/Swiss-Prot ID Q9P2D0
UniProtKB/Swiss-Prot Entry Name IBTK_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015525.2
GeneCard ID IBTK
GenAtlas ID IBTK
HGNC ID HGNC:17853
References
General References Not Available