| Identification |
|---|
| HMDB Protein ID
| CDBP02948 |
| Secondary Accession Numbers
| Not Available |
| Name
| Homer protein homolog 3 |
| Description
| Not Available |
| Synonyms
|
- Homer-3
|
| Gene Name
| HOMER3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metabotropic glutamate receptor signaling p |
| Specific Function
| Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- Cell junction
- Cell junction
- synapse
- synapse
- postsynaptic cell membrane
- postsynaptic density
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.11 |
| SNPs
| HOMER3 |
| Gene Sequence
|
>1086 bp
ATGTCCACAGCCAGGGAGCAGCCAATCTTCAGCACACGGGCGCACGTGTTCCAAATTGAC
CCAGCCACCAAGCGAAACTGGATCCCAGCGGGCAAGCACGCACTCACTGTCTCCTATTTC
TACGATGCCACCCGCAATGTGTACCGCATCATCAGCATCGGAGGCGCCAAGGCCATCATC
AACAGCACTGTCACTCCCAACATGACCTTCACCAAAACTTCCCAGAAGTTCGGGCAGTGG
GCCGACAGTCGCGCCAACACAGTCTACGGCCTGGGCTTTGCCTCTGAACAGCATCTGACA
CAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTGGCCAGGGAGAAATCT
CAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCG
AGCCCTCTCGTCAGTGCCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCT
GATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTGTCTGAGGGCTCCGTG
GGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCA
GGCGCCCTGCGAGAGGCCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAG
CGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAGGCTCAGGCAGCTTCA
GAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTG
GAAGCTCTGGTGCAAACCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGG
CCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAGAAGGTGCAGGACCTG
GAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAG
GCACGGGCAGAGCGGGAGCGGGCGCGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGAC
GTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCCTGGCTGAGGCTGCG
CCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 361 |
| Molecular Weight
| 39836.0 |
| Theoretical pI
| 5.15 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Homer protein homolog 3
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
P
|
| External Links |
|---|
| GenBank ID Protein
| 224809414 |
| UniProtKB/Swiss-Prot ID
| Q9NSC5 |
| UniProtKB/Swiss-Prot Entry Name
| HOME3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001145722.1 |
| GeneCard ID
| HOMER3 |
| GenAtlas ID
| HOMER3 |
| HGNC ID
| HGNC:17514 |
| References |
|---|
| General References
| Not Available |