| Identification |
|---|
| HMDB Protein ID
| CDBP02937 |
| Secondary Accession Numbers
| Not Available |
| Name
| Guanylyl cyclase-activating protein 1 |
| Description
| Not Available |
| Synonyms
|
- GCAP 1
- Guanylate cyclase activator 1A
|
| Gene Name
| GUCA1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure |
| GO Classification
|
| Function |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| cation binding |
|
| Cellular Location
|
- Lipid-anchor
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.1 |
| SNPs
| GUCA1A |
| Gene Sequence
|
>606 bp
ATGGGCAACGTGATGGAGGGAAAGTCAGTGGAGGAGCTGAGCAGCACCGAGTGCCACCAG
TGGTACAAGAAGTTCATGACTGAGTGCCCCTCTGGCCAACTCACCCTCTATGAGTTCCGC
CAGTTCTTCGGCCTCAAGAACCTGAGCCCGTCGGCCAGCCAGTACGTGGAACAGATGTTT
GAGACTTTTGACTTCAACAAGGACGGCTACATTGATTTCATGGAGTACGTGGCAGCGCTC
AGCTTGGTCCTCAAGGGGAAGGTGGAACAGAAGCTCCGCTGGTACTTCAAGCTCTATGAT
GTAGATGGCAACGGCTGCATTGACCGCGATGAGCTGCTCACCATCATCCAGGCCATTCGC
GCCATTAACCCCTGCAGCGATACCACCATGACTGCAGAGGAGTTCACCGATACAGTGTTC
TCCAAGATTGACGTCAACGGGGATGGGGAACTCTCCCTGGAAGAGTTTATAGAGGGCGTC
CAGAAGGACCAGATGCTCCTGGACACACTGACACGAAGCCTGGACCTTACCCGCATCGTG
CGCAGGCTCCAGAATGGCGAGCAAGACGAGGAGGGGGCTGACGAGGCCGCTGAGGCAGCC
GGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 201 |
| Molecular Weight
| 22919.5 |
| Theoretical pI
| 4.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Guanylyl cyclase-activating protein 1
MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMF
ETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIR
AINPCSDTTMTAEEFTDTVFSKIDVNGDGELSLEEFIEGVQKDQMLLDTLTRSLDLTRIV
RRLQNGEQDEEGADEAAEAAG
|
| External Links |
|---|
| GenBank ID Protein
| 193785093 |
| UniProtKB/Swiss-Prot ID
| P43080 |
| UniProtKB/Swiss-Prot Entry Name
| GUC1A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK125780 |
| GeneCard ID
| GUCA1A |
| GenAtlas ID
| GUCA1A |
| HGNC ID
| HGNC:4678 |
| References |
|---|
| General References
| Not Available |