Identification |
HMDB Protein ID
| CDBP02923 |
Secondary Accession Numbers
| Not Available |
Name
| GC-rich sequence DNA-binding factor |
Description
| Not Available |
Synonyms
|
- GCF
- TCF-9
- Transcription factor 9
|
Gene Name
| TCF9 |
Protein Type
| Transcription Factor |
Biological Properties |
General Function
| Involved in DNA binding |
Specific Function
| Factor that represses transcription. It binds to the GC- rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters |
GO Classification
|
Component |
organelle |
membrane-bounded organelle |
intracellular membrane-bounded organelle |
nucleus |
Function |
binding |
nucleic acid binding |
dna binding |
sequence-specific dna binding transcription factor activity |
Process |
regulation of biological process |
regulation of metabolic process |
regulation of macromolecule metabolic process |
regulation of gene expression |
regulation of transcription |
biological regulation |
|
Cellular Location
|
- Nucleus
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| TCF9 |
Gene Sequence
|
>2346 bp
ATGGCTCACAGGCCGAAAAGGACTTTTCGGCAGCGCGCGGCTGATTCCAGCGACAGCGAT
GGCGCCGAGGAGTCGCCTGCTGAGCCTGGGGCGCCGAGGGAACTTCCGGTCCCGGGTTCT
GCGGAGGAAGAGCCGCCCTCTGGAGGAGGCCGCGCGCAGGTGGCGGGACTGCCCCACCGG
GTTCGGGGCCCTCGTGGCCGGGGCCGGGTCTGGGCGAGCTCCCGGCGTGCCACCAAAGCG
GCTCCCCGCGCGGACGAAGGCTCAGAATCCAGAACCCTTGATGTGTCCACAGATGAAGAG
GATAAAATACATCACTCCTCAGAAAGTAAGGATGATCAGGGTTTGTCTTCTGACAGTTCT
AGCTCTCTTGGAGAAAAAGAACTTTCATCAACAGTTAAGATCCCAGATGCAGCTTTTATT
CAGGCAGCCCGCAGAAAACGTGAATTGGCCAGGGCCCAAGATGACTATATTTCTTTGGAT
GTACAACATACCTCCTCCATCTCTGGTATGAAGAGAGAGAGCGAAGATGACCCTGAGAGT
GAGCCTGATGACCATGAAAAGAGAATACCATTTACTCTAAGACCTCAAACACTTAGACAA
AGGATGGCTGAGGAATCAATAAGCAGAAATGAAGAAACAAGTGAAGAAAGTCAGGAAGAT
GAAAAGCAAGATACTTGGGAACAACAGCAAATGAGGAAAGCAGTTAAAATCATAGAGGAA
AGAGACATAGATCTTTCCTGTGGCAATGGATCTTCAAAAGTGAAGAAATTTGATACTTCC
ATTTCATTTCCGCCAGTAAATTTAGAAATTATAAAGAAGCAATTAAATACTAGATTAACA
TTACTACAGGAAACTCACCGCTCACACCTGAGGGAGTATGAAAAATACGTACAAGATGTC
AAAAGCTCAAAGAGTACCATCCAGAACCTAGAGAGTTCATCAAATCAAGCTCTAAATTGT
AAATTCTATAAAAGCATGAAAATTTATGTGGAAAATTTAATTGACTGCCTTAATGAAAAG
ATTATCAACATCCAAGAAATAGAATCATCCATGCATGCACTCCTTTTAAAACAAGCTATG
ACCTTTATGAAACGCAGGCAAGATGAATTAAAACATGAATCAACGTATTTACAACAGTTA
TCACGCAAAGATGAGACATCCACAAGTGGAAACTTCTCAGTAGATGAAAAAACTCAGTGG
ATTTTAGAAGAGATTGAATCTCGAAGGACAAAAAGAAGACAAGCAAGGGTGCTTTCTGGG
AATTGTAACCATCAGGAAGGAACATCTAGTGATGATGAACTGCCTTCAGCAGAGATGATT
GACTTCCAAAAAAGCCAAGGTGACATTTTACAGAAACAGAAGAAAGTTTTTGAAGAAGTG
CAAGATGATTTTTGTAACATCCAGAATATTTTGTTGAAATTTCAGCAATGGCGAGAAAAG
TTTCCTGACTCCTATTATGAAGCTTTCATTAGTTTATGCATACCAAAGCTTTTAAATCCC
CTAATACGAGTTCAGTTGATTGATTGGAATCCTCTTAAGTTGGAATCCACAGGTTTAAAA
GAGATGCCATGGTTCAAATCTGTAGAAGAATTTATGGATAGCAGTGTGGAAGATTCAAAG
AAGGAAAGTAGTTCAGATAAAAAAGTCTTGTCTGCAATCATCAACAAAACAATTATTCCC
CGACTTACAGACTTTGTAGAATTCCTTTGGGATCCTTTGTCAACCTCACAGACAACAAGT
TTAATAACACATTGCAGAGTGATTCTTGAAGAACATTCCACTTGTGAAAATGAAGTTAGT
AAAAGCAGACAGGATTTACTTAAATCCATTGTTTCAAGAATGAAAAAGGCAGTAGAAGAT
GATGTTTTTATTCCTCTGTATCCAAAGAGTGCTGTAGAAAACAAAACATCACCTCATTCA
AAGTTCCAAGAAAGACAGTTCTGGTCAGGCCTAAAGCTCTTCCGCAATATTCTTCTTTGG
AATGGACTCCTTACAGATGACACCTTGCAAGAACTAGGACTAGGGAAGCTGCTAAATCGT
TACCTTATTATAGCACTTCTCAATGCCACACCTGGGCCAGATGTGGTTAAAAAGTGCAAC
CAGGTAGCAGCATGTCTACCAGAAAAATGGTTTGAAAATTCTGCCATGAGGACATCTATT
CCACAGCTAGAAAACTTCATTCAGTTTTTATTGCAGTCTGCACATAAATTATCTAGAAGT
GAATTCAGGGATGAAGTCGAAGAAATAATTCTTATTTTGGTGAAAATAAAAGCTTTGAAT
CAAGCAGAATCCTTCATAGGAGAGCATCACCTAGACCATCTTAAATCACTAATTAAAGAA
GATTGA
|
Protein Properties |
Number of Residues
| 781 |
Molecular Weight
| 89383.7 |
Theoretical pI
| 5.81 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>GC-rich sequence DNA-binding factor
MAHRPKRTFRQRAADSSDSDGAEESPAEPGAPRELPVPGSAEEEPPSGGGRAQVAGLPHR
VRGPRGRGRVWASSRRATKAAPRADEGSESRTLDVSTDEEDKIHHSSESKDDQGLSSDSS
SSLGEKELSSTVKIPDAAFIQAARRKRELARAQDDYISLDVQHTSSISGMKRESEDDPES
EPDDHEKRIPFTLRPQTLRQRMAEESISRNEETSEESQEDEKQDTWEQQQMRKAVKIIEE
RDIDLSCGNGSSKVKKFDTSISFPPVNLEIIKKQLNTRLTLLQETHRSHLREYEKYVQDV
KSSKSTIQNLESSSNQALNCKFYKSMKIYVENLIDCLNEKIINIQEIESSMHALLLKQAM
TFMKRRQDELKHESTYLQQLSRKDETSTSGNFSVDEKTQWILEEIESRRTKRRQARVLSG
NCNHQEGTSSDDELPSAEMIDFQKSQGDILQKQKKVFEEVQDDFCNIQNILLKFQQWREK
FPDSYYEAFISLCIPKLLNPLIRVQLIDWNPLKLESTGLKEMPWFKSVEEFMDSSVEDSK
KESSSDKKVLSAIINKTIIPRLTDFVEFLWDPLSTSQTTSLITHCRVILEEHSTCENEVS
KSRQDLLKSIVSRMKKAVEDDVFIPLYPKSAVENKTSPHSKFQERQFWSGLKLFRNILLW
NGLLTDDTLQELGLGKLLNRYLIIALLNATPGPDVVKKCNQVAACLPEKWFENSAMRTSI
PQLENFIQFLLQSAHKLSRSEFRDEVEEIILILVKIKALNQAESFIGEHHLDHLKSLIKE
D
|
External Links |
GenBank ID Protein
| 62822425 |
UniProtKB/Swiss-Prot ID
| P16383 |
UniProtKB/Swiss-Prot Entry Name
| GCF_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AC005034 |
GeneCard ID
| TCF9 |
GenAtlas ID
| TCF9 |
HGNC ID
| HGNC:1317 |
References |
General References
| Not Available |