| Identification |
|---|
| HMDB Protein ID
| CDBP02915 |
| Secondary Accession Numbers
| Not Available |
| Name
| Frizzled-4 |
| Description
| Not Available |
| Synonyms
|
- CD344 antigen
- Fz-4
- FzE4
- hFz4
|
| Gene Name
| FZD4 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in cell surface receptor linked signaling pathway |
| Specific Function
| Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q14.2 |
| SNPs
| FZD4 |
| Gene Sequence
|
>1614 bp
ATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGTCTCAGT
CTGGGGTTGCTCCTGCAGTTGCTGCTGCTCCTGGGGCCGGCGCGGGGCTTCGGGGACGAG
GAAGAGCGGCGCTGCGACCCCATCCGCATCTCCATGTGCCAGAACCTCGGCTACAACGTG
ACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAGCTGACA
ACTTTCACACCGCTCATCCAGTACGGCTGCTCCAGCCAGCTGCAGTTCTTCCTTTGTTCT
GTTTATGTGCCAATGTGCACAGAGAAGATCAACATCCCCATTGGCCCATGCGGCGGCATG
TGTCTTTCAGTCAAGAGACGCTGTGAACCCGTCCTGAAGGAATTTGGATTTGCCTGGCCA
GAGAGTCTGAACTGCAGCAAATTCCCACCACAGAACGACCACAACCACATGTGCATGGAA
GGGCCAGGTGATGAAGAGGTGCCCTTACCTCACAAAACCCCCATCCAGCCTGGGGAAGAG
TGTCACTCTGTGGGAACCAATTCTGATCAGTACATCTGGGTGAAAAGGAGCCTGAACTGT
GTGCTCAAGTGTGGCTATGATGCTGGCTTATACAGCCGCTCAGCCAAGGAGTTCACTGAT
ATCTGGATGGCTGTGTGGGCCAGCCTGTGTTTCATCTCCACTGCCTTCACAGTACTGACC
TTCCTGATCGATTCTTCTAGGTTTTCCTACCCTGAGCGCCCCATCATATTTCTCAGTATG
TGCTATAATATTTATAGCATTGCTTATATTGTCAGGCTGACTGTAGGCCGGGAAAGGATA
TCCTGTGATTTTGAAGAGGCAGCAGAACCTGTTCTCATCCAAGAAGGACTTAAGAACACA
GGATGTGCAATAATTTTCTTGCTGATGTACTTTTTTGGAATGGCCAGCTCCATTTGGTGG
GTTATTCTGACACTCACTTGGTTTTTGGCAGCAGGACTCAAATGGGGTCATGAAGCCATT
GAAATGCACAGCTCTTATTTCCACATTGCAGCCTGGGCCATCCCCGCAGTGAAAACCATT
GTCATCTTGATTATGAGACTGGTGGATGCAGATGAACTGACTGGCTTGTGCTATGTTGGA
AACCAAAATCTCGATGCCCTCACCGGGTTCGTGGTGGCTCCCCTCTTTACTTATTTGGTC
ATTGGAACTTTGTTCATTGCTGCAGGTTTGGTGGCCTTGTTCAAAATTCGGTCAAATCTT
CAAAAGGATGGGACAAAGACAGACAAGTTAGAAAGACTGATGGTCAAGATTGGGGTGTTC
TCAGTACTGTACACAGTTCCTGCAACGTGTGTGATTGCCTGTTATTTTTATGAAATCTCC
AACTGGGCACTTTTTCGGTATTCTGCAGATGATTCCAACATGGCTGTTGAAATGTTGAAA
ACTTTTATGTCTTTGTTGGTGGGCATCACTTCAGGCATGTGGATTTGGTCTGCCAAAAGT
CTTCACACGTGGCAGAAGTGTTCCAACAGATTGGTGAATTCTGGAAAGGTAAAGAGAGAG
AAGAGAGGAAATGGTTGGGTGAAGCCTGGAAAAGGCAGTGAGACTGTGGTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 537 |
| Molecular Weight
| 59880.5 |
| Theoretical pI
| 7.29 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["223-243", "255-275", "303-323", "345-365", "390-410", "437-457", "478-498"]
|
| Protein Sequence
|
>Frizzled-4
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNV
TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM
CLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE
CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT
FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT
GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI
VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL
QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK
IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
|
| External Links |
|---|
| GenBank ID Protein
| 6277266 |
| UniProtKB/Swiss-Prot ID
| Q9ULV1 |
| UniProtKB/Swiss-Prot Entry Name
| FZD4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB032417 |
| GeneCard ID
| FZD4 |
| GenAtlas ID
| FZD4 |
| HGNC ID
| HGNC:4042 |
| References |
|---|
| General References
| Not Available |