Showing Protein Peptidyl-prolyl cis-trans isomerase FKBP8 (CDBP02902)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02902
Secondary Accession Numbers Not Available
Name Peptidyl-prolyl cis-trans isomerase FKBP8
Description Not Available
Synonyms
  1. 38 kDa FK506-binding protein
  2. 38 kDa FKBP
  3. FK506-binding protein 8
  4. FKBP-38
  5. FKBP-8
  6. FKBPR38
  7. PPIase FKBP8
  8. Rotamase
  9. hFKBP38
Gene Name FKBP8
Protein Type Enzyme
Biological Properties
General Function Involved in protein folding
Specific Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis
GO Classification
Function
binding
Process
macromolecule metabolic process
cellular protein metabolic process
protein folding
protein metabolic process
metabolic process
Cellular Location
  1. Mitochondrion membrane
  2. Cytoplasmic side
  3. Single-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19p12
SNPs FKBP8
Gene Sequence 
>1239 bp
ATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCG
CTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAG
GAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCACCGCTGGAGGACATGGGACAA
CCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATG
GAGCCCGAGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGGAACGGG
CTGTTGAGGAAGAAGACGCTGGTCCCAGGGCCGCCAGGTTCGAGCCGCCCGGTCAAGGGC
CAGGTGGTCACCGTACATCTGCAGACGTCGCTGGAGAATGGCACACGGGTGCAGGAGGAG
CCGGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAGGCCCTGGATCTCAGTGTC
CCACTCATGGACGTGGGGGAGACGGCCATGGTCACTGCTGACTCCAAGTACTGCTACGGC
CCCCAAGGCAGGAGCCCATACATCCCCCCGCACGCGGCCCTGTGCCTGGAGGTGACCCTG
AAGACGGCTGTGGACGGGCCTGACCTGGAGATGCTCACGGGGCAGGAGCGCGTGGCCCTG
GCCAACCGGAAGCGGGAGTGCGGCAACGCCCACTACCAGCGGGCGGACTTCGTCCTGGCC
GCCAACTCCTACGACCTCGCCATCAAGGCTATCACCTCCAGCGCCAAAGTGGACATGACG
TTCGAGGAGGAGGCACAGCTCCTGCAGTTGAAGGTGAAGTGTCTGAACAACCTGGCGGCC
TCGCAGCTGAAGCTCGACCACTACCGCGCAGCCCTGCGCTCCTGCAGCCTTGTGCTGGAG
CACCAGCCAGACAACATCAAGGCTCTCTTCCGCAAGGGCAAGGTGCTGGCCCAGCAGGGG
GAGTACAGTGAGGCCATCCCCATCCTGAGGGCAGCCCTGAAGCTGGAACCTTCCAACAAG
ACGATCCACGCAGAGCTCTCAAAGCTGGTGAAGAAGCATGCGGCGCAGCGGAGCACGGAG
ACCGCCTTGTACCGGAAAATGCTGGGCAACCCCAGCCGGCTGCCTGCTAAGTGCCCTGGC
AAGGGTGCCTGGTCCATCCCATGGAAGTGGCTGTTTGGGGCGACTGCTGTTGCCTTGGGG
GGTGTGGCACTCTCTGTGGTCATCGCTGCCAGGAACTGA
Protein Properties
Number of Residues 412
Molecular Weight 44561.3
Theoretical pI 4.49
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["390-410"]
Protein Sequence 
>Peptidyl-prolyl cis-trans isomerase FKBP8
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQ
PPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKG
QVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYG
PQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLA
ANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLE
HQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTE
TALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
GenBank ID Protein 28395543
UniProtKB/Swiss-Prot ID Q14318
UniProtKB/Swiss-Prot Entry Name FKBP8_HUMAN
PDB IDs Not Available
GenBank Gene ID AY225339
GeneCard ID FKBP8
GenAtlas ID FKBP8
HGNC ID HGNC:3724
References
General References Not Available