Showing Protein Peptidyl-prolyl cis-trans isomerase FKBP1A (CDBP02900)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02900
Secondary Accession Numbers Not Available
Name Peptidyl-prolyl cis-trans isomerase FKBP1A
Description Not Available
Synonyms
  1. 12 kDa FK506-binding protein
  2. 12 kDa FKBP
  3. FK506-binding protein 1A
  4. FKBP-12
  5. FKBP-1A
  6. Immunophilin FKBP12
  7. PPIase FKBP1A
  8. Rotamase
Gene Name FKBP1A
Protein Type Enzyme
Biological Properties
General Function Involved in protein folding
Specific Function May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO Classification
Process
metabolic process
macromolecule metabolic process
cellular protein metabolic process
protein folding
protein metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 20p13
SNPs FKBP1A
Gene Sequence 
>327 bp
ATGGGAGTGCAGGTGGAAACCATCTCCCCAGGAGACGGGCGCACCTTCCCCAAGCGCGGC
CAGACCTGCGTGGTGCACTACACCGGGATGCTTGAAGATGGAAAGAAATTTGATTCCTCC
CGGGACAGAAACAAGCCCTTTAAGTTTATGCTAGGCAAGCAGGAGGTGATCCGAGGCTGG
GAAGAAGGGGTTGCCCAGATGAGTGTGGGTCAGAGAGCCAAACTGACTATATCTCCAGAT
TATGCCTATGGTGCCACTGGGCACCCAGGCATCATCCCACCACATGCCACTCTCGTCTTC
GATGTGGAGCTTCTAAAACTGGAATGA
Protein Properties
Number of Residues 108
Molecular Weight 11950.7
Theoretical pI 8.48
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Peptidyl-prolyl cis-trans isomerase FKBP1A
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P62942
UniProtKB/Swiss-Prot Entry Name FKB1A_HUMAN
PDB IDs
GenBank Gene ID M34539
GeneCard ID FKBP1A
GenAtlas ID FKBP1A
HGNC ID HGNC:3711
References
General References Not Available