| Identification |
|---|
| HMDB Protein ID
| CDBP02898 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ficolin-2 |
| Description
| Not Available |
| Synonyms
|
- 37 kDa elastin-binding protein
- Collagen/fibrinogen domain-containing protein 2
- EBP-37
- Ficolin-B
- Ficolin-beta
- Hucolin
- L-ficolin
- Serum lectin p35
|
| Gene Name
| FCN2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in receptor binding |
| Specific Function
| May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region |
| GO Classification
|
| Component |
| extracellular region part |
| extracellular space |
| Function |
| binding |
| protein binding |
| receptor binding |
| Process |
| signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34.3 |
| SNPs
| FCN2 |
| Gene Sequence
|
>942 bp
ATGGAGCTGGACAGAGCTGTGGGGGTCCTGGGCGCTGCCACCCTGCTGCTCTCTTTCCTG
GGCATGGCCTGGGCTCTCCAGGCGGCAGACACCTGTCCAGAGGTGAAGATGGTGGGCCTG
GAGGGCTCTGACAAGCTCACCATTCTCCGAGGCTGTCCGGGGCTGCCTGGGGCCCCTGGG
CCCAAGGGAGAGGCAGGCACCAATGGAAAGAGAGGAGAACGTGGCCCCCCTGGACCTCCT
GGGAAGGCAGGACCACCTGGGCCCAACGGAGCACCTGGGGAGCCCCAGCCGTGCCTGACA
GGCCCGCGTACCTGCAAGGACCTGCTAGACCGAGGGTACTTCCTGAGCGGCTGGCACACC
ATCTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGG
GGCTGGACCGTTTTCCAGCGGAGGGTGGATGGCTCTGTGGACTTCTACCGGGACTGGGCC
ACGTACAAGCAGGGCTTCGGCAGTCGGCTGGGGGAGTTCTGGCTGGGGAATGACAACATC
CACGCCCTGACCGCCCAGGGAACCAGCGAGCTCCGTGTAGACCTGGTGGACTTTGAGGAC
AACTACCAGTTTGCTAAGTACAGATCATTCAAGGTGGCCGACGAGGCGGAGAAGTACAAT
CTGGTCCTGGGGGCCTTCGTGGAGGGCAGTGCGGGAGATTCCCTGACGTTCCACAACAAC
CAGTCCTTCTCCACCAAAGACCAGGACAATGATCTTAACACCGGAAATTGTGCTGTGATG
TTTCAGGGAGCTTGGTGGTACAAAAACTGCCATGTGTCAAACCTGAATGGTCGCTACCTC
AGGGGGACTCATGGCAGCTTTGCAAATGGCATCAACTGGAAGTCGGGGAAAGGATACAAT
TATAGCTACAAGGTGTCAGAGATGAAGGTGCGACCTGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 313 |
| Molecular Weight
| 34000.9 |
| Theoretical pI
| 6.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ficolin-2
MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPG
PKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHT
IYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNI
HALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNN
QSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYN
YSYKVSEMKVRPA
|
| External Links |
|---|
| GenBank ID Protein
| 158255122 |
| UniProtKB/Swiss-Prot ID
| Q15485 |
| UniProtKB/Swiss-Prot Entry Name
| FCN2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK290843 |
| GeneCard ID
| FCN2 |
| GenAtlas ID
| FCN2 |
| HGNC ID
| HGNC:3624 |
| References |
|---|
| General References
| Not Available |