| Identification |
|---|
| HMDB Protein ID
| CDBP02873 |
| Secondary Accession Numbers
| Not Available |
| Name
| Desmoglein-1 |
| Description
| Not Available |
| Synonyms
|
- Cadherin family member 4
- DG1
- DGI
- Desmosomal glycoprotein 1
- Pemphigus foliaceus antigen
|
| Gene Name
| DSG1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion |
| GO Classification
|
| Component |
| cell part |
| plasma membrane |
| membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- desmosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.1 |
| SNPs
| DSG1 |
| Gene Sequence
|
>3150 bp
ATGGACTGGAGTTTCTTCAGAGTAGTTGCAATGCTGTTCATTTTTCTGGTGGTGGTAGAA
GTTAACAGTGAATTCCGAATCCAGGTAAGAGATTATAACACTAAAAATGGCACCATCAAA
TGGCATTCAATCCGAAGGCAGAAACGTGAATGGATCAAGTTCGCAGCAGCCTGTCGTGAA
GGTGAAGACAACTCAAAGAGGAACCCAATCGCCAAAATTCACTCAGATTGTGCTGCAAAC
CAGCAAGTTACATACCGCATCTCTGGAGTAGGAATTGATCAGCCACCATATGGGATCTTT
GTCATTAATCAGAAAACTGGTGAAATTAATATAACATCCATAGTTGATCGAGAGGTCACT
CCTTTCTTCATTATCTACTGCCGAGCTCTGAACTCAATGGGCCAAGATTTAGAGAGGCCT
CTAGAGCTCAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTGTTTTCAATGGCT
ACATTTGCAGGACAAATAGAAGAAAATTCTAATGCAAATACACTGGTGATGATACTCAAT
GCTACTGACGCAGATGAACCGAACAATTTGAACTCAAAAATAGCCTTCAAGATTATAAGA
CAAGAACCTTCAGATTCACCAATGTTTATTATCAACAGAAATACTGGAGAAATTCGAACG
ATGAATAATTTTCTAGACAGAGAGCAATACGGCCAGTATGCTCTTGCTGTAAGAGGCTCT
GACCGAGATGGTGGGGCAGATGGCATGTCAGCGGAATGTGAGTGCAACATTAAAATCCTC
GATGTCAATGATAATATCCCTTACATGGAACAGTCTTCATATACCATAGAAATTCAAGAA
AATACTCTAAATTCAAATTTGCTCGAGATTAGAGTAATTGATTTGGATGAAGAGTTCTCA
GCTAACTGGATGGCAGTAATTTTCTTTATCTCTGGAAATGAAGGAAATTGGTTTGAGATA
GAAATGAATGAAAGAACAAATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGATTATGAA
GCTATGCAGAGTCTGCAACTCAGTATTGGTGTCAGAAATAAAGCTGAATTTCATCATTCA
ATTATGTCTCAATATAAACTGAAAGCATCTGCAATTTCTGTGACTGTGTTAAATGTAATT
GAAGGCCCAGTGTTTCGTCCAGGTTCAAAGACATATGTTGTAACTGGTAATATGGGATCA
AATGATAAAGTGGGAGACTTTGTAGCTACTGACCTGGACACAGGTAGACCTTCAACGACT
GTTAGGTATGTAATGGGAAATAATCCAGCTGACCTGCTAGCTGTTGATTCAAGAACAGGC
AAACTCACTTTGAAAAATAAAGTTACCAAGGAACAGTACAATATGCTCGGAGGAAAATAC
CAAGGAACGATTCTCTCTATAGATGATAATCTTCAAAGAACTTGCACTGGTACAATTAAT
ATTAACATTCAAAGTTTTGGTAATGACGACAGGACTAATACAGAGCCGAACACTAAAATT
ACTACCAATACTGGCAGACAAGAAAGTACTTCTTCCACTAACTATGATACCAGCACAACT
TCTACTGACTCTAGCCAAGTATATTCTTCTGAACCCGGAAACGGAGCCAAAGATTTGTTA
TCAGACAATGTACATTTTGGTCCTGCTGGCATTGGACTCCTCATCATGGGATTCTTGGTC
TTAGGATTGGTCCCATTTTTGATGATCTGTTGTGATTGTGGAGGTGCTCCTCGTAGTGCA
GCTGGCTTTGAGCCTGTTCCCGAATGTTCAGATGGAGCAATTCATTCATGGGCAGTAGAA
GGACCACAGCCTGAACCCAGGGATATAACCACTGTCATACCACAAATACCACCTGATAAC
GCAAATATAATTGAATGCATTGACAACTCAGGAGTTTATACAAATGAGTATGGTGGCAGA
GAAATGCAAGATCTGGGAGGAGGAGAGAGAATGACAGGATTTGAACTAACAGAGGGAGTT
AAAACTTCAGGAATGCCTGAGATATGTCAAGAATACTCTGGAACATTAAGAAGAAATTCT
ATGAGGGAATGTAGAGAAGGAGGTCTGAATATGAATTTCATGGAAAGCTACTTCTGTCAG
AAAGCATATGCTTACGCAGATGAAGATGAAGGACGCCCATCTAATGACTGTTTGCTCATA
TATGACATCGAAGGTGTAGGTTCCCCTGCTGGCTCTGTGGGTTGTTGTAGCTTCATTGGA
GAAGACCTGGATGACAGCTTCTTGGATACCCTGGGACCTAAATTTAAGAAGTTGGCAGAC
ATCAGCCTAGGAAAAGAATCATATCCAGACCTTGATCCTTCTTGGCCACCACAAAGCACT
GAACCAGTTTGCCTTCCTCAGGAAACAGAGCCCGTTGTTAGTGGACACCCACCAATCTCC
CCACATTTCGGCACTACCACAGTAATTTCTGAGAGCACCTATCCCTCGGGACCTGGTGTA
CTGCATCCTAAGCCTATTCTCGATCCTCTGGGCTATGGTAATGTCACTGTGACCGAGTCT
TACACCACCTCTGACACTCTGAAGCCCTCTGTGCACGTTCACGATAACCGACCAGCATCA
AACGTGGTAGTGACAGAGAGAGTGGTCGGCCCAATCTCTGGCGCTGATTTGCATGGAATG
TTAGAGATGCCTGACTTGCGAGATGGGTCGAATGTTATAGTGACAGAAAGGGTAATAGCA
CCAAGCTCTAGTCTACCCACCTCTCTGACTATCCATCATCCTAGAGAGTCTTCAAATGTG
GTAGTGACAGAAAGAGTAATCCAACCAACTTCCGGCATGATAGGTAGTCTGAGTATGCAC
CCCGAGTTAGCCAATGCCCACAATGTCATTGTGACAGAGAGGGTTGTTTCTGGTGCTGGC
GTAACTGGAATTAGTGGCACCACTGGGATCAGCGGTGGCATAGGCAGCAGTGGCCTGGTT
GGCACCAGCATGGGTGCTGGGAGCGGTGCCCTGAGTGGAGCTGGCATAAGTGGTGGTGGC
ATTGGCCTGAGCAGCTTGGGAGGGACAGCCAGCATTGGCCACATGAGGAGTTCCTCTGAC
CATCACTTTAACCAAACCATTGGGTCCGCCTCCCCTAGCACAGCTCGAAGTCGAATCACA
AAGTATAGTACCGTGCAATATAGCAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1049 |
| Molecular Weight
| 113746.7 |
| Theoretical pI
| 4.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Desmoglein-1
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE
GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT
PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS
DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS
ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS
IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTT
VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN
INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLL
SDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE
GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGV
KTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI
YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQST
EPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES
YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIA
PSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG
VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSD
HHFNQTIGSASPSTARSRITKYSTVQYSK
|
| External Links |
|---|
| GenBank ID Protein
| 119703744 |
| UniProtKB/Swiss-Prot ID
| Q02413 |
| UniProtKB/Swiss-Prot Entry Name
| DSG1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001942.2 |
| GeneCard ID
| DSG1 |
| GenAtlas ID
| DSG1 |
| HGNC ID
| HGNC:3048 |
| References |
|---|
| General References
| Not Available |