| Identification |
|---|
| HMDB Protein ID
| CDBP02871 |
| Secondary Accession Numbers
| Not Available |
| Name
| Desmocollin-2 |
| Description
| Not Available |
| Synonyms
|
- Cadherin family member 2
- Desmocollin-3
- Desmosomal glycoprotein II
- Desmosomal glycoprotein III
|
| Gene Name
| DSC2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| plasma membrane |
| intrinsic to membrane |
| integral to membrane |
| membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- desmosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.1 |
| SNPs
| DSC2 |
| Gene Sequence
|
>2706 bp
ATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTG
ACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCC
TCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCT
GCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTAT
ACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAAC
ACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTCCTA
AAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATT
CCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAA
TCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAA
GAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCT
GTAGATCGTGAGCAGTATGAATCTTTTGAGATAATTGCCTTTGCAACAACTCCAGATGGG
TATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTAC
CCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGCACT
ACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTG
AAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACT
ACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAG
TTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACT
TGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTTAT
GTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGAT
AAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAA
AATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTT
AAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAA
GCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTT
AATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATG
AAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACA
AGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATT
GATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATC
AAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACG
GGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAG
ACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGAT
GAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAG
AGAATGTGGAGACTGAAAGCAATTAATGATACAGCAGCACGTCTTTCCTATCAGAATGAT
CCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGT
GTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGT
GTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATA
TTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGG
ACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCA
AACACAGAAGCTCCTGGAGATGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACT
GTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGT
CAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCT
GGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGA
TACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAAAAGTGTATCTG
TGTAATCAAGATGAAAATCACAAGCATGCCCAAGACTATGTCCTGACATATAACTATGAA
GGAAGAGGATCGGTGGCTGGGTCTGTAGGTTGTTGCAGTGAACGACAAGAAGAAGATGGG
CTTGAATTTTTGGATAATTTGGAGCCCAAATTTAGGACACTAGCAGAAGCATGCATGAAG
AGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 901 |
| Molecular Weight
| 99960.9 |
| Theoretical pI
| 4.98 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Desmocollin-2
MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTA
ANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVL
KKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQ
EPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY
PIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPT
TGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSY
VTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVV
KPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRM
KENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETI
KNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPD
EPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSS
VTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASG
TSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGG
QETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYL
CNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMK
R
|
| External Links |
|---|
| GenBank ID Protein
| 38648769 |
| UniProtKB/Swiss-Prot ID
| Q02487 |
| UniProtKB/Swiss-Prot Entry Name
| DSC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC063291 |
| GeneCard ID
| DSC2 |
| GenAtlas ID
| DSC2 |
| HGNC ID
| HGNC:3036 |
| References |
|---|
| General References
| Not Available |