Identification
HMDB Protein ID CDBP02870
Secondary Accession Numbers Not Available
Name Desmocollin-1
Description Not Available
Synonyms
  1. Cadherin family member 1
  2. DG2/DG3
  3. Desmosomal glycoprotein 2/3
Gene Name DSC1
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues
GO Classification
Component
plasma membrane
intrinsic to membrane
integral to membrane
membrane
cell part
membrane part
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
  3. Cell junction
  4. desmosome
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 18q12.2|18q12.1
SNPs DSC1
Gene Sequence
>2685 bp
ATGGCTCTGGCCTCTGCTGCCCCAGGGAGCATCTTCTGTAAGCAGCTCCTTTTCTCTCTC
CTGGTTTTAACATTACTTTGCGATGCTTGTCAGAAAGTTTATCTTCGAGTTCCTTCTCAT
CTTCAGGCTGAAACACTTGTAGGCAAAGTGAATCTGGAGGAGTGTCTCAAGTCGGCCAGC
CTAATCCGGTCCAGTGACCCTGCCTTCAGAATTCTAGAAGATGGCTCAATTTACACAACA
CATGACCTCATTTTGTCTTCTGAAAGGAAAAGTTTTTCCATTTTCCTTTCAGATGGTCAG
AGACGGGAACAACAAGAGATAAAAGTTGTACTGTCAGCAAGAGAAAACAAGTCTCCTAAG
AAGAGACATACCAAAGACACAGCCCTCAAGCGCAGCAAGAGACGATGGGCTCCTATTCCA
GCTTCATTGATGGAGAACTCGTTGGGTCCATTTCCACAACACGTTCAGCAGATCCAATCT
GATGCTGCACAGAATTACACCATCTTTTATTCCATAAGTGGGCCAGGCGTGGACAAAGAA
CCCTTCAATTTGTTTTACATAGAGAAAGACACTGGGGATATCTTTTGTACAAGGAGCATT
GACCGTGAGAAATACGAACAGTTTGCGTTATATGGCTATGCAACAACTGCAGATGGCTAT
GCACCAGAATATCCACTCCCTTTGATCATCAAAATTGAAGATGATAATGATAACGCCCCA
TATTTTGAACACAGAGTGACTATCTTTACTGTGCCTGAAAATTGCCGATCCGGAACTTCA
GTGGGAAAAGTGACCGCCACAGACCTTGACGAACCTGACACTCTCCATACTCGTCTGAAA
TATAAAATCTTACAACAAATCCCAGATCATCCAAAGCATTTCTCCATACACCCAGATACC
GGTGTCATCACCACAACTACACCTTTTCTGGATAGAGAAAAATGTGATACTTACCAGTTA
ATAATGGAAGTGCGAGACATGGGTGGTCAGCCTTTCGGTTTATTTAATACAGGAACAATT
ACTATTTCACTTGAGGATGAAAATGACAATCCACCATCTTTCACAGAAACTTCTTATGTT
ACAGAAGTAGAAGAAAACAGAATTGACGTGGAGATTTTGCGAATGAAGGTACAGGATCAG
GATTTGCCAAACACTCCTCACTCAAAGGCTGTATACAAAATCTTACAAGGAAATGAAAAT
GGAAACTTCATAATTAGCACAGATCCAAATACAAATGAAGGAGTGCTGTGTGTTGTCAAG
CCATTGAACTATGAAGTCAATCGCCAAGTTATTTTGCAAGTTGGTGTCATTAACGAGGCA
CAATTCTCTAAAGCAGCGAGCTCACAAACTCCTACAATGTGCACTACAACTGTCACCGTT
AAAATTATAGACAGTGATGAGGGCCCTGAATGCCACCCTCCAGTGAAAGTTATTCAGAGT
CAAGATGGCTTCCCAGCTGGCCAAGAACTCCTTGGATACAAAGCACTGGACCCGGAAATA
TCCAGTGGTGAAGGCTTAAGGTATCAGAAGTTAGGGGATGAAGATAACTGGTTTGAAATT
AATCAACACACTGGCGACTTGAGAACTCTAAAAGTACTAGATAGAGAATCCAAATTTGTA
AAAAACAACCAATACAATATTTCAGTTGTTGCAGTGGATGCAGTTGGCCGATCTTGCACT
GGAACATTAGTAGTTCATTTGGATGATTACAACGATCACGCACCTCAAATTGACAAAGAA
GTGACCATTTGTCAGAATAATGAGGATTTTGCTGTTCTGAAACCTGTAGATCCAGATGGA
CCTGAAAATGGACCACCTTTTCAATTCTTTCTGGATAATTCTGCCAGTAAAAACTGGAAC
ATAGAAGAAAAGGATGGTAAAACTGCCATTCTTCGTCAACGGCAAAATCTTGATTATAAC
TATTATTCTGTGCCTATTCAAATAAAAGACAGGCATGGTTTAGTTGCAACACATATGTTA
ACAGTGAGAGTATGTGACTGTTCAACTCCATCTGAGTGTAGAATGAAGGATAAAAGTACA
AGAGACGTTAGACCAAATGTAATACTTGGAAGATGGGCTATTCTTGCTATGGTGTTGGGT
TCTGTATTGTTATTATGTATTCTGTTTACATGTTTCTGTGTCACTGCTAAGAGAACAGTC
AAGAAATGTTTTCCAGAAGACATAGCCCAGCAAAATTTAATTGTATCAAATACTGAAGGA
CCTGGAGAAGAAGTAACGGAAGCAAATATTAGACTCCCCATGCAGACATCCAACATTTGT
GACACAAGCATGTCTGTTGGTACTGTTGGTGGCCAGGGAATCAAAACACAGCAAAGTTTT
GAGATGGTCAAAGGAGGCTACACTTTGGATTCCAACAAAGGAGGTGGACATCAGACCTTG
GAGTCCGTCAAGGGAGTGGGGCAGGGAGATACTGGCAGATATGCGTACACGGACTGGCAG
AGTTTCACCCAACCTCGGCTTGGCGAAAAGGTGTATTTGTGTGGACAAGATGAGGAGCAT
AAACATTGTGAAGACTACGTTTGTTCGTATAACTATGAAGGCAAAGGTTCTCTGGCCGGC
TCAGTAGGTTGCTGCAGCGATCGGCAGGAAGAAGAGGGACTGGAGTTTCTAGATCACCTG
GAACCCAAATTTAGGACATTAGCAAAGACATGCATCAAGAAATAA
Protein Properties
Number of Residues 894
Molecular Weight 99986.1
Theoretical pI 5.08
Pfam Domain Function
Signals
  • ["1-29"]
Transmembrane Regions
  • ["692-714"]
Protein Sequence
>Desmocollin-1
MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS
LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK
KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE
PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP
YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT
GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV
TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK
PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS
QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV
KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG
PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML
TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV
KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF
EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEH
KHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK
GenBank ID Protein 10801202
UniProtKB/Swiss-Prot ID Q08554
UniProtKB/Swiss-Prot Entry Name DSC1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF293358
GeneCard ID DSC1
GenAtlas ID DSC1
HGNC ID HGNC:3035
References
General References Not Available