| Identification |
|---|
| HMDB Protein ID
| CDBP02868 |
| Secondary Accession Numbers
| Not Available |
| Name
| Double C2-like domain-containing protein alpha |
| Description
| Not Available |
| Synonyms
|
- Doc2
- Doc2-alpha
|
| Gene Name
| DOC2A |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells |
| GO Classification
|
| Component |
| cytoplasmic vesicle |
| cytoplasmic membrane-bounded vesicle |
| coated vesicle |
| clathrin-coated vesicle |
| synaptic vesicle |
| membrane |
| cell part |
| organelle |
| vesicle |
| Function |
| transporter activity |
| Process |
| transport |
| establishment of localization |
|
| Cellular Location
|
- Lysosome
- Cytoplasmic vesicle
- secretory vesicle
- Cell junction
- synapse
- Peripheral membrane protein (Probable)
- synaptosome
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p11.2 |
| SNPs
| DOC2A |
| Gene Sequence
|
>1203 bp
ATGAGGGGCCGCAGGGGCGATCGCATGACCATCAACATCCAGGAGCACATGGCCATCAAC
GTGTGCCCCGGGCCCATCCGGCCCATCCGCCAGATCTCTGACTACTTCCCCCGGGGACCA
GGACCTGAAGGGGGCGGCGGGGGCGGCGGGGAGGCCCCCGCCCATCTGGTCCCCCTGGCT
CTGGCCCCCCCTGCAGCCCTCCTTGGGGCCACCACGCCTGAGGATGGTGCGGAGGTGGAC
AGCTATGACTCGGATGATGCCACCGCCCTAGGCACGCTGGAGTTTGACCTTCTCTACGAC
CGGGCCTCCTGCACTCTGCACTGTAGCATCCTCAGGGCCAAGGGCCTCAAGCCCATGGAT
TTCAATGGCCTCGCCGACCCCTACGTCAAGCTGCACTTGCTGCCTGGAGCCTGTAAGGCC
AATAAGCTAAAAACGAAGACTCAGAGGAACACACTGAATCCCGTGTGGAATGAGGACCTG
ACTTACAGCGGGATCACAGATGACGACATCACGCACAAGGTGCTCAGGATCGCCGTCTGT
GATGAGGACAAGCTGAGTCACAATGAGTTTATTGGGGAGATCCGCGTGCCCCTCCGCCGC
CTCAAGCCTTCGCAGAAGAAGCATTTTAACATCTGCCTCGAGCGCCAGGTCCCGCTGGCG
TCCCCCTCTTCCATGTCAGCGGCGCTGAGGGGCATCTCCTGTTATCTGAAGGAGTTGGAG
CAGGCGGAGCAGGGGCAGGGGCTGCTGGAGGAGCGTGGCCGCATCCTGCTGAGTCTCAGC
TACAGCTCGCGGCGCCGGGGACTGCTGGTAGGCATCTTGCGCTGCGCCCATCTGGCTGCC
ATGGACGTCAACGGTTACTCGGACCCCTACGTCAAGACGTACCTGAGGCCCGATGTGGAC
AAGAAATCCAAGCATAAGACGTGTGTGAAGAAGAAGACTCTCAACCCAGAATTTAACGAG
GAGTTTTTCTACGAGATAGAGCTCTCCACTCTGGCCACCAAGACCCTGGAAGTCACCGTC
TGGGACTATGACATTGGCAAATCCAATGACTTCATTGGTGGCGTGTCCCTGGGGCCAGGT
GCCCGAGGCGAGGCTCGGAAGCACTGGAGTGACTGCCTGCAGCAGCCGGACGCAGCCCTG
GAGCGCTGGCACACCCTGACCAGTGAGCTGCCCCCTGCGGCCGGGGCTCTGTCCTCAGCC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 400 |
| Molecular Weight
| 43958.6 |
| Theoretical pI
| 7.27 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Double C2-like domain-containing protein alpha
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLA
LAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMD
FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC
DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE
QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD
KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG
ARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA
|
| External Links |
|---|
| GenBank ID Protein
| 71052058 |
| UniProtKB/Swiss-Prot ID
| Q14183 |
| UniProtKB/Swiss-Prot Entry Name
| DOC2A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC041769 |
| GeneCard ID
| DOC2A |
| GenAtlas ID
| DOC2A |
| HGNC ID
| HGNC:2985 |
| References |
|---|
| General References
| Not Available |