Identification
HMDB Protein ID CDBP02868
Secondary Accession Numbers Not Available
Name Double C2-like domain-containing protein alpha
Description Not Available
Synonyms
  1. Doc2
  2. Doc2-alpha
Gene Name DOC2A
Protein Type Transporter
Biological Properties
General Function Involved in transporter activity
Specific Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells
GO Classification
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
organelle
vesicle
Function
transporter activity
Process
transport
establishment of localization
Cellular Location
  1. Lysosome
  2. Cytoplasmic vesicle
  3. secretory vesicle
  4. Cell junction
  5. synapse
  6. Peripheral membrane protein (Probable)
  7. synaptosome
  8. synaptic vesicle membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16p11.2
SNPs DOC2A
Gene Sequence
>1203 bp
ATGAGGGGCCGCAGGGGCGATCGCATGACCATCAACATCCAGGAGCACATGGCCATCAAC
GTGTGCCCCGGGCCCATCCGGCCCATCCGCCAGATCTCTGACTACTTCCCCCGGGGACCA
GGACCTGAAGGGGGCGGCGGGGGCGGCGGGGAGGCCCCCGCCCATCTGGTCCCCCTGGCT
CTGGCCCCCCCTGCAGCCCTCCTTGGGGCCACCACGCCTGAGGATGGTGCGGAGGTGGAC
AGCTATGACTCGGATGATGCCACCGCCCTAGGCACGCTGGAGTTTGACCTTCTCTACGAC
CGGGCCTCCTGCACTCTGCACTGTAGCATCCTCAGGGCCAAGGGCCTCAAGCCCATGGAT
TTCAATGGCCTCGCCGACCCCTACGTCAAGCTGCACTTGCTGCCTGGAGCCTGTAAGGCC
AATAAGCTAAAAACGAAGACTCAGAGGAACACACTGAATCCCGTGTGGAATGAGGACCTG
ACTTACAGCGGGATCACAGATGACGACATCACGCACAAGGTGCTCAGGATCGCCGTCTGT
GATGAGGACAAGCTGAGTCACAATGAGTTTATTGGGGAGATCCGCGTGCCCCTCCGCCGC
CTCAAGCCTTCGCAGAAGAAGCATTTTAACATCTGCCTCGAGCGCCAGGTCCCGCTGGCG
TCCCCCTCTTCCATGTCAGCGGCGCTGAGGGGCATCTCCTGTTATCTGAAGGAGTTGGAG
CAGGCGGAGCAGGGGCAGGGGCTGCTGGAGGAGCGTGGCCGCATCCTGCTGAGTCTCAGC
TACAGCTCGCGGCGCCGGGGACTGCTGGTAGGCATCTTGCGCTGCGCCCATCTGGCTGCC
ATGGACGTCAACGGTTACTCGGACCCCTACGTCAAGACGTACCTGAGGCCCGATGTGGAC
AAGAAATCCAAGCATAAGACGTGTGTGAAGAAGAAGACTCTCAACCCAGAATTTAACGAG
GAGTTTTTCTACGAGATAGAGCTCTCCACTCTGGCCACCAAGACCCTGGAAGTCACCGTC
TGGGACTATGACATTGGCAAATCCAATGACTTCATTGGTGGCGTGTCCCTGGGGCCAGGT
GCCCGAGGCGAGGCTCGGAAGCACTGGAGTGACTGCCTGCAGCAGCCGGACGCAGCCCTG
GAGCGCTGGCACACCCTGACCAGTGAGCTGCCCCCTGCGGCCGGGGCTCTGTCCTCAGCC
TGA
Protein Properties
Number of Residues 400
Molecular Weight 43958.6
Theoretical pI 7.27
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Double C2-like domain-containing protein alpha
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLA
LAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMD
FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC
DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE
QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD
KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG
ARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA
GenBank ID Protein 71052058
UniProtKB/Swiss-Prot ID Q14183
UniProtKB/Swiss-Prot Entry Name DOC2A_HUMAN
PDB IDs Not Available
GenBank Gene ID BC041769
GeneCard ID DOC2A
GenAtlas ID DOC2A
HGNC ID HGNC:2985
References
General References Not Available