| Identification |
|---|
| HMDB Protein ID
| CDBP02863 |
| Secondary Accession Numbers
| Not Available |
| Name
| Deleted in malignant brain tumors 1 protein |
| Description
| Not Available |
| Synonyms
|
- Glycoprotein 340
- Gp-340
- Hensin
- SAG
- Salivary agglutinin
- Surfactant pulmonary-associated D-binding protein
|
| Gene Name
| DMBT1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in scavenger receptor activity |
| Specific Function
| May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly- sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| receptor activity |
| transmembrane receptor activity |
| scavenger receptor activity |
| molecular transducer activity |
| signal transducer activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q26.13 |
| SNPs
| DMBT1 |
| Gene Sequence
|
>7242 bp
ATGGGGATCTCCACAGTCATCCTTGAAATGTGTCTTTTATGGGGACAAGTTCTATCTACA
GGTGGGTGGATCCCAAGGACTACAGACTACGCTTCACTGATTCCCTCGGAGGTGCCCTTG
GATCCAACTGTAGCAGAAGGTTCTCCATTTCCCTCGGAGTCGACCCTGGAGTCAACTGTA
GCAGAAGGTTCTCCGATTTCCTTGGAGTCAACCCTGGAGTCAACCGTAGCAGAAGGTTCT
CTGATTCCCTCAGAGTCAACCCTGGAGTCAACTGTAGCAGAAGGATCTGATTCTGGTTTG
GCCCTGAGGCTGGTGAATGGAGATGGCAGGTGTCAGGGCCGAGTGGAGATCCTATACCGA
GGCTCCTGGGGCACCGTGTGTGATGACAGCTGGGACACCAATGATGCCAACGTGGTCTGT
AGGCAGCTGGGTTGTGGCTGGGCCATGTCAGCTCCAGGAAATGCCTGGTTTGGCCAGGGC
TCAGGACCCATTGCCCTGGATGATGTGCGCTGCTCAGGACACGAATCCTACCTGTGGAGC
TGCCCCCACAATGGCTGGCTCTCCCATAACTGTGGCCATGGTGAAGATGCTGGTGTTATC
TGCTCAGCTGCCCAGCCTCAGTCAACACTCAGGCCAGAAAGTTGGCCTGTCAGGATATCA
CCACCTGTACCCACAGAAGGATCTGAATCCAGTTTGGCCCTGAGGCTGGTGAATGGAGGC
GACAGGTGTCGAGGCCGAGTGGAGGTCCTATACCGAGGCTCCTGGGGCACCGTGTGTGAT
GACTACTGGGACACCAATGATGCCAATGTGGTCTGCAGGCAGCTGGGCTGTGGCTGGGCC
ATGTCAGCCCCAGGAAATGCCCAGTTTGGCCAGGGCTCAGGACCCATTGTCCTGGATGAT
GTGCGCTGCTCAGGACATGAGTCCTACCTGTGGAGCTGCCCCCACAATGGCTGGCTCACC
CACAACTGTGGCCATAGTGAAGACGCTGGTGTCATCTGCTCAGCTCCCCAGTCCCGGCCG
ACACCCAGCCCAGATACTTGGCCGACCTCACATGCATCAACAGCAGGACCTGAATCCAGT
TTGGCCCTGAGGCTGGTGAATGGAGGTGACAGGTGTCAGGGCCGAGTGGAGGTCCTATAC
CGAGGCTCCTGGGGCACCGTGTGTGATGATAGCTGGGACACCAGTGACGCCAATGTGGTC
TGCCGGCAGCTGGGCTGTGGCTGGGCCACGTCAGCCCCAGGAAATGCCCGGTTTGGCCAG
GGTTCAGGACCCATTGTCCTGGATGACGTGCGCTGCTCAGGCTATGAGTCCTACCTGTGG
AGCTGCCCCCACAATGGCTGGCTCTCCCATAACTGTCAGCACAGTGAAGACGCTGGTGTC
ATCTGCTCAGCTGCCCACTCCTGGTCGACGCCCAGTCCAGACACGTTGCCGACCATCACC
TTACCTGCATCGACAGTAGGATCTGAATCCAGTTTGGCCCTGAGGCTGGTGAATGGAGGT
GACAGGTGTCAGGGCCGAGTGGAGGTCCTATACCGAGGCTCCTGGGGCACCGTGTGTGAT
GACAGCTGGGACACCAATGATGCCAATGTGGTCTGCAGGCAGCTGGGCTGTGGCTGGGCC
ATGTTGGCCCCAGGAAATGCCCGGTTTGGTCAGGGCTCAGGACCCATTGTCCTGGATGAC
GTGCGCTGCTCAGGGAATGAGTCCTACTTGTGGAGCTGCCCCCACAATGGCTGGCTCTCC
CATAACTGTGGCCATAGTGAAGACGCTGGTGTCATCTGCTCAGGACCTGAATCCAGTTTG
GCCCTGAGGCTGGTGAATGGAGGTGACAGGTGTCAGGGCCGAGTGGAGGTCCTATACCGA
GGCTCTTGGGGCACCGTGTGTGATGACAGCTGGGACACCAATGATGCCAATGTGGTCTGC
AGGCAGCTGGGCTGTGGCTGGGCCACGTCAGCCCCAGGAAATGCCCGGTTTGGTCAGGGC
TCAGGACCCATTGTCCTGGATGATGTGCGCTGCTCAGGACATGAGTCCTACCTGTGGAGC
TGCCCCAACAATGGCTGGCTCTCCCACAACTGTGGCCATCATGAAGATGCTGGTGTCATC
TGCTCAGCTGCCCAGTCCCGGTCGACGCCCAGGCCAGACACGTTGTCGACCATCACGTTA
CCTCCATCGACAGTAGGATCTGAATCCAGTTTGACCCTGAGGCTGGTGAATGGAAGTGAC
AGGTGTCAGGGCCGAGTAGAGGTCCTATACCGAGGCTCCTGGGGCACCGTGTGTGATGAC
AGCTGGGATACCAATGATGCCAATGTGGTCTGCAGGCAGCTGGGCTGTGGCTGGGCCACG
TCGGCCCCAGGAAATGCCCGGTTTGGCCAGGGCTCAGGACCCATTGTTCTGGATGATGTG
CGCTGCTCAGGACACGAGTCCTACCTGTGGAGCTGCCCCCACAATGGCTGGCTCTCCCAC
AACTGTGGCCATCATGAAGATGCTGGTGTCATCTGCTCAGTTTCCCAGTCCCGGCCGACA
CCCAGTCCAGATACTTGGCCGACCTCACATGCATCAACAGCAGGACCTGAATCCAGTTTG
GCCCTGAGGCTGGTGAATGGAGGTGACAGGTGTCAGGGCCGAGTGGAGGTCCTATACCGA
GGCTCCTGGGGCACCGTGTGTGATGATAGCTGGGACACCAGTGACGCCAATGTGGTCTGC
CGGCAGCTGGGCTGTGGCTGGGCCACGTCAGCCCCAGGAAATGCCCGGTTTGGCCAGGGT
TCAGGACCCATTGTCCTGGATGACGTGCGCTGCTCAGGCTATGAGTCCTACCTGTGGAGC
TGCCCCCACAATGGCTGGCTCTCCCATAACTGTCAGCACAGTGAAGACGCTGGTGTCATC
TGCTCAGCTGCCCACTCCTGGTCGACGCCCAGTCCAGACACATTGCCGACCATCACCTTG
CCTGCATCGACAGTAGGATCTGAATCCAGTTTGGCCCTGAGGCTGGTGAATGGAGGTGAC
AGGTGTCAGGGCCGAGTGGAGGTCCTATACCAAGGCTCCTGGGGCACCGTGTGCGATGAC
AGCTGGGACACCAATGATGCCAATGTCGTCTGCAGGCAACTGGGCTGTGGCTGGGCCATG
TCAGCCCCAGGAAATGCCCGGTTTGGTCAGGGCTCAGGACCCATTGTCCTGGATGATGTG
CGCTGCTCAGGACACGAGTCTTACCTGTGGAGCTGCCCCCACAATGGCTGGCTCTCCCAC
AACTGTGGCCATAGTGAAGACGCTGGTGTCATCTGCTCAGCTTCCCAGTCCCGGCCAACA
CCTAGTCCAGACACTTGGCCAACCTCACATGCATCAACAGCAGGATCTGAATCCAGTTTG
GCCCTGAGGCTGGTGAATGGAGGTGACAGGTGTCAGGGCCGAGTGGAGGTCCTATACCGA
GGCTCCTGGGGCACCGTGTGTGATGACTACTGGGACACCAATGATGCCAATGTGGTTTGC
AGGCAGCTGGGCTGTGGCTGGGCCATGTCAGCCCCAGGAAATGCCCGGTTTGGCCAGGGT
TCAGGACCCATTGTCCTGGATGATGTGCGCTGCTCAGGACATGAGTCCTATCTGTGGAGC
TGCCCCCACAATGGCTGGCTCTCCCACAACTGTGGCCATCATGAAGACGCTGGTGTCATC
TGCTCAGCTTCCCAGTCCCAGCCGACACCCAGCCCAGACACTTGGCCAACCTCACATGCA
TCAACAGCAGGATCTGAATCCAGTTTGGCCCTGAGGCTGGTGAATGGAGGTGACAGGTGT
CAGGGCCGAGTGGAGGTCCTATACCGAGGCTCCTGGGGCACCGTGTGTGATGACTACTGG
GACACCAATGATGCCAATGTGGTTTGCAGGCAGCTGGGCTGTGGCTGGGCCACGTCAGCC
CCAGGAAATGCCCGGTTTGGCCAGGGTTCAGGACCCATTGTCCTGGATGATGTGCGCTGC
TCAGGACATGAGTCCTATCTGTGGAGCTGCCCCCACAATGGCTGGCTCTCCCACAACTGT
GGCCATCATGAAGACGCTGGTGTCATCTGCTCAGCTTCCCAGTCCCAGCCGACACCCAGC
CCAGACACTTGGCCAACCTCACATGCATCAACAGCAGGATCTGAATCCAGTTTGGCCCTG
AGGCTGGTGAATGGAGGTGACAGGTGTCAGGGCCGAGTGGAGGTCCTATACCGAGGCTCC
TGGGGCACCGTGTGTGATGACTACTGGGACACCAATGATGCCAATGTGGTTTGCAGGCAG
CTGGGCTGTGGCTGGGCCACGTCAGCCCCAGGAAATGCCCGGTTTGGCCAGGGTTCAGGA
CCCATTGTCCTGGATGATGTGCGCTGCTCAGGACATGAGTCCTATCTGTGGAGCTGCCCC
CACAATGGCTGGCTCTCCCACAACTGTGGCCATCATGAAGACGCTGGTGTCATCTGCTCA
GCTTCCCAGTCCCAGCCGACACCCAGCCCAGACACTTGGCCAACCTCTCGTGCATCAACA
GCAGGATCTGAATCCACTTTGGCCCTGAGACTGGTGAATGGAGGTGACAGGTGTCGAGGC
CGAGTGGAGGTCCTATACCAAGGCTCCTGGGGCACCGTGTGTGATGACTACTGGGACACC
AATGATGCCAACGTGGTCTGCAGGCAGCTGGGCTGTGGCTGGGCCATGTCAGCCCCAGGA
AATGCCCAGTTTGGCCAGGGCTCAGGACCCATTGTCCTGGATGATGTGCGCTGCTCAGGA
CACGAGTCTTACCTGTGGAGCTGCCCCCACAATGGCTGGCTCTCCCACAACTGTGGCCAT
CATGAAGATGCTGGTGTCATCTGCTCAGCTGCTCAGTCCCAGTCAACGCCCAGGCCAGAT
ACTTGGCTGACCACCAACTTACCGGCATTGACAGTAGGATCTGAATCCAGTTTGGCTCTG
AGGCTGGTGAATGGAGGTGACAGGTGTCGAGGCCGAGTGGAGGTCCTGTATCGAGGCTCC
TGGGGAACCGTGTGTGATGACAGCTGGGACACCAATGATGCCAATGTGGTCTGCAGGCAG
CTGGGCTGTGGCTGGGCCATGTCGGCCCCAGGAAATGCCCGGTTTGGCCAGGGCTCAGGA
CCCATTGTCCTGGATGATGTGCGCTGCTCAGGGAATGAGTCCTACCTGTGGAGCTGCCCC
CACAAAGGCTGGCTCACCCACAACTGTGGCCATCACGAAGACGCTGGTGTCATCTGCTCA
GCCACCCAAATAAATTCTACTACGACAGATTGGTGGCATCCAACAACTACAACCACTGCA
AGACCCTCTTCAAATTGTGGTGGCTTCTTATTCTATGCCAGTGGGACATTCTCCAGCCCA
TCCTACCCTGCATACTACCCCAACAATGCTAAGTGTGTTTGGGAAATAGAAGTGAATTCT
GGTTATCGCATAAACCTGGGCTTCAGTAATCTGAAATTGGAGGCACACCATAACTGCAGT
TTTGATTATGTTGAAATCTTTGATGGATCATTGAATAGCAGTCTCCTGCTGGGGAAAATC
TGTAATGATACCAGGCAAATATTTACATCTTCTTACAACCGAATGACCATTCACTTTCGA
AGTGACATCAGTTTCCAAAACACTGGCTTTTTGGCTTGGTATAACTCCTTCCCAAGCGAT
GCCACCTTGAGGTTGGTCAATTTAAATTCATCCTATGGTCTATGTGCCGGGCGTGTAGAA
ATTTACCATGGTGGCACCTGGGGGACAGTTTGTGATGACTCCTGGACCATTCAGGAAGCT
GAGGTGGTCTGCAGACAGCTAGGGTGTGGACGTGCAGTTTCAGCCCTTGGAAATGCATAT
TTTGGCTCTGGCTCTGGCCCCATCACCCTGGACGATGTAGAGTGCTCAGGGACGGAATCC
ACTCTCTGGCAGTGCCGGAACCGAGGCTGGTTCTCCCACAACTGTAATCATCGTGAAGAT
GCTGGTGTCATCTGCTCAGGAAACCATCTATCGACACCTGCTCCTTTTCTCAACATCACC
CGTCCAAACACAGATTATTCCTGCGGAGGCTTCCTATCCCAACCATCAGGGGACTTTTCC
AGCCCATTCTATCCCGGGAACTATCCAAACAATGCCAAGTGTGTGTGGGACATTGAGGTG
CAAAACAACTACCGTGTGACTGTGATCTTCAGAGATGTCCAGCTTGAAGGTGGCTGCAAC
TATGATTATATTGAAGTTTTCGATGGCCCCTACCGCAGTTCCCCTCTCATTGCTCGAGTT
TGTGATGGGGCCAGAGGCTCCTTCACTTCTTCCTCCAACTTCATGTCCATTCGCTTCATC
AGTGACCACAGCATCACAAGGAGAGGGTTCCGGGCTGAGTACTACTCCAGTCCCTCCAAT
GACAGCACCAACCTGCTCTGTCTGCCAAATCACATGCAAGCCAGTGTGAGCAGGAGCTAT
CTCCAATCCTTGGGCTTTTCTGCCAGTGACCTTGTCATTTCCACCTGGAATGGATACTAC
GAGTGTCGGCCCCAGATAACGCCGAACCTGGTGATATTCACAATTCCCTACTCAGGCTGC
GGCACCTTCAAGCAGGCAGACAATGACACCATCGACTATTCCAACTTCCTCACAGCAGCT
GTCTCAGGTGGCATCATCAAGAGGAGGACAGACCTCCGTATTCACGTCAGCTGCAGAATG
CTTCAGAACACCTGGGTCGACACCATGTACATTGCTAATGACACCATCCACGTTGCTAAT
AACACCATCCAGGTCGAGGAAGTCCAGTATGGCAATTTTGACGTGAACATTTCCTTTTAT
ACTTCCTCATCTTTCTTGTATCCTGTGACCAGCCGCCCTTACTACGTGGACCTGAACCAG
GACTTGTACGTTCAGGCTGAAATCCTCCATTCTGATGCTGTACTGACCTTGTTTGTGGAC
ACCTGCGTGGCATCACCATACTCCAATGACTTCACGTCTTTGACTTATGATCTAATCCGG
AGTGGATGCGTGAGGGATGACACCTACGGACCCTACTCCTCGCCATCTCTTCGCATTGCC
CGCTTCCGGTTCAGGGCCTTCCACTTCCTGAACCGCTTCCCCTCCGTGTACCTGCGTTGT
AAAATGGTGGTGTGCAGAGCGTATGACCCCTCTTCCCGCTGCTACCGAGGCTGTGTGTTG
AGGTCGAAGAGGGATGTGGGCTCCTACCAGGAAAAGGTGGACGTCGTCCTGGGTCCCATC
CAGCTGCAGACCCCCCCACGCCGAGAAGAGGAGCCTCGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 2413 |
| Molecular Weight
| 260733.2 |
| Theoretical pI
| 5.11 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Deleted in malignant brain tumors 1 protein
MGISTVILEMCLLWGQVLSTGGWIPRTTDYASLIPSEVPLDPTVAEGSPFPSESTLESTV
AEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYR
GSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWS
CPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGG
DRCRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDD
VRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESS
LALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCGWATSAPGNARFGQ
GSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTIT
LPASTVGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWA
MLAPGNARFGQGSGPIVLDDVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSL
ALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQG
SGPIVLDDVRCSGHESYLWSCPNNGWLSHNCGHHEDAGVICSAAQSRSTPRPDTLSTITL
PPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAT
SAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSVSQSRPT
PSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVC
RQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVI
CSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQGSWGTVCDD
SWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSH
NCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR
GSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWS
CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC
QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC
SGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLAL
RLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSG
PIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRAST
AGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPG
NAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSAAQSQSTPRPD
TWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQ
LGCGWAMSAPGNARFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICS
ATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNS
GYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICNDTRQIFTSSYNRMTIHFR
SDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEA
EVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHRED
AGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEV
QNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFI
SDHSITRRGFRAEYYSSPSNDSTNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYY
ECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTDLRIHVSCRM
LQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQ
DLYVQAEILHSDAVLTLFVDTCVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIA
RFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQEKVDVVLGPI
QLQTPPRREEEPR
|
| External Links |
|---|
| GenBank ID Protein
| 148539842 |
| UniProtKB/Swiss-Prot ID
| Q9UGM3 |
| UniProtKB/Swiss-Prot Entry Name
| DMBT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007329.2 |
| GeneCard ID
| DMBT1 |
| GenAtlas ID
| DMBT1 |
| HGNC ID
| HGNC:2926 |
| References |
|---|
| General References
| Not Available |