| Identification |
|---|
| HMDB Protein ID
| CDBP02862 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neuronal migration protein doublecortin |
| Description
| Not Available |
| Synonyms
|
- Doublin
- Lis-X
- Lissencephalin-X
|
| Gene Name
| DCX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration |
| GO Classification
|
| Process |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| DCX |
| Gene Sequence
|
>1326 bp
ATGAAAACACTCCCCCTTCATAGTCATTGTACTGAAATGCAAAGACTGCTTCCTAAGCTG
GAGATGCTAACCTTGGGTAGCTCCTTCTGTTCTCTTCAAGGGGAATTTTGTCAGGCTATG
GATTCATTTACAACTGTTAGTCATGTGGGCATGTGTGAGGAAACAGATGCCAGTTTTAAT
GTATTTAGCCCGAAGTTCCAATTTGATAGGAGCCACTGTCAGTCTCTGAGGTTCCACCAA
AATATGGAACTTGATTTTGGACACTTTGACGAAAGAGATAAGACATCCAGGAACATGCGA
GGCTCCCGGATGAATGGGTTGCCTAGCCCCACTCACAGCGCCCACTGTAGCTTCTACCGA
ACCAGAACCTTGCAGGCACTGAGTAATGAGAAGAAAGCCAAGAAGGTACGTTTCTACCGC
AATGGGGACCGCTACTTCAAGGGGATTGTGTACGCTGTGTCCTCTGACCGTTTTCGCAGC
TTTGACGCCTTGCTGGCTGACCTGACGCGATCTCTGTCTGACAACATCAACCTGCCTCAG
GGAGTGCGTTACATTTACACCATTGATGGATCCAGGAAGATCGGAAGCATGGATGAACTG
GAGGAAGGGGAAAGCTATGTCTGTTCCTCAGACAACTTCTTTAAAAAGGTGGAGTACACC
AAGAATGTCAATCCCAACTGGTCTGTCAACGTAAAAACATCTGCCAATATGAAAGCCCCC
CAGTCCTTGGCTAGCAGCAACAGTGCACAGGCCAGGGAGAACAAGGACTTTGTGCGCCCC
AAGCTGGTTACCATCATCCGCAGTGGGGTGAAGCCTCGGAAGGCTGTGCGTGTGCTTCTG
AACAAGAAGACAGCCCACTCTTTTGAGCAAGTCCTCACTGATATCACAGAAGCCATCAAA
CTGGAGACCGGGGTTGTCAAAAAACTCTACACTCTGGATGGAAAACAGGTAACTTGTCTC
CATGATTTCTTTGGTGATGATGATGTGTTTATTGCCTGTGGTCCTGAAAAATTTCGCTAT
GCTCAGGATGATTTTTCTCTGGATGAAAATGAATGCCGAGTCATGAAGGGAAACCCATCA
GCCACAGCTGGCCCAAAGGCATCCCCAACACCTCAGAAGACTTCAGCCAAGAGCCCTGGT
CCTATGCGCCGAAGCAAGTCTCCAGCTGACTCAGCAAACGGAACCTCCAGCAGCCAGCTC
TCTACCCCCAAGTCTAAGCAGTCTCCCATCTCTACGCCCACCAGTCCTGGCAGCCTCCGG
AAGCACAAGGACCTGTACCTGCCTCTGTCCTTGGATGACTCGGACTCGCTTGGTGATTCC
ATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 441 |
| Molecular Weight
| 49317.2 |
| Theoretical pI
| 9.29 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Neuronal migration protein doublecortin
MKTLPLHSHCTEMQRLLPKLEMLTLGSSFCSLQGEFCQAMDSFTTVSHVGMCEETDASFN
VFSPKFQFDRSHCQSLRFHQNMELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYR
TRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQ
GVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAP
QSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIK
LETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPS
ATAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLR
KHKDLYLPLSLDDSDSLGDSM
|
| External Links |
|---|
| GenBank ID Protein
| 30181246 |
| UniProtKB/Swiss-Prot ID
| O43602 |
| UniProtKB/Swiss-Prot Entry Name
| DCX_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_000555.3 |
| GeneCard ID
| DCX |
| GenAtlas ID
| DCX |
| HGNC ID
| HGNC:2714 |
| References |
|---|
| General References
| Not Available |