| Identification |
|---|
| HMDB Protein ID
| CDBP02857 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-X-C chemokine receptor type 2 |
| Description
| Not Available |
| Synonyms
|
- CD182 antigen
- CDw128b
- CXC-R2
- CXCR-2
- GRO/MGSA receptor
- High affinity interleukin-8 receptor B
- IL-8 receptor type 2
- IL-8R B
|
| Gene Name
| CXCR2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| interleukin-8 receptor activity |
| receptor activity |
| transmembrane receptor activity |
| cytokine receptor activity |
| molecular transducer activity |
| signal transducer activity |
| Process |
| response to stimulus |
| response to chemical stimulus |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| chemotaxis |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q35 |
| SNPs
| CXCR2 |
| Gene Sequence
|
>1083 bp
ATGGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGGAAAGGTGAAGATCTT
AGTAATTACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCCGCCCCATGTGAA
CCAGAATCCCTGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCCCTGGTATTCCTG
CTGAGCCTGCTGGGAAACTCCCTCGTGATGCTGGTCATCTTATACAGCAGGGTCGGCCGC
TCCGTCACTGATGTCTACCTGCTGAACCTAGCCTTGGCCGACCTACTCTTTGCCCTGACC
TTGCCCATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAG
GTGGTCTCACTCCTGAAGGAAGTCAACTTCTATAGTGGCATCCTGCTACTGGCCTGCATC
AGTGTGGACCGTTACCTGGCCATTGTCCATGCCACACGCACACTGACCCAGAAGCGCTAC
TTGGTCAAATTCATATGTCTCAGCATCTGGGGTCTGTCCTTGCTCCTGGCCCTGCCTGTC
TTACTTTTCCGAAGGACCGTCTACTCATCCAATGTTAGCCCAGCCTGCTATGAGGACATG
GGCAACAATACAGCAAACTGGCGGATGCTGTTACGGATCCTGCCCCAGTCCTTTGGCTTC
ATCGTGCCACTGCTGATCATGCTGTTCTGCTACGGATTCACCCTGCGTACGCTGTTTAAG
GCCCACATGGGGCAGAAGCACCGGGCCATGCGGGTCATCTTTGCTGTCGTCCTCATCTTC
CTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGCTGGCAGACACCCTCATGAGGACCCAG
GTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCGACCGGGCTCTGGATGCCACCGAG
ATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTACGCCTTCATTGGCCAGAAG
TTTCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATCAGCAAGGACTCCCTG
CCCAAAGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACTTCCACTACTCTC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 360 |
| Molecular Weight
| 40758.7 |
| Theoretical pI
| 8.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["49-75", "85-105", "121-142", "164-183", "209-231", "252-273", "295-315"]
|
| Protein Sequence
|
>C-X-C chemokine receptor type 2
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
|
| External Links |
|---|
| GenBank ID Protein
| 269973859 |
| UniProtKB/Swiss-Prot ID
| P25025 |
| UniProtKB/Swiss-Prot Entry Name
| CXCR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001168298.1 |
| GeneCard ID
| CXCR2 |
| GenAtlas ID
| CXCR2 |
| HGNC ID
| HGNC:6027 |
| References |
|---|
| General References
| Not Available |