Identification
HMDB Protein ID CDBP02853
Secondary Accession Numbers Not Available
Name Cation channel sperm-associated protein 2
Description Not Available
Synonyms
  1. CatSper2
Gene Name CATSPER2
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization
GO Classification
Component
membrane
cell part
Function
ion transmembrane transporter activity
transporter activity
ion channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Multi-pass membrane protein
  2. Cell projection
  3. cilium
  4. flagellum membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 15q15.3
SNPs CATSPER2
Gene Sequence
>1593 bp
ATGGCCGCTTACCAACAAGAAGAGCAGATGCAGCTTCCCCGAGCTGATGCCATTCGTTCA
CGTCTCATCGATACTTTCTCTCTCATTGAGCATTTGCAAGGCTTGAGCCAAGCTGTGCCG
CGGCACACTATCAGGGAGTTACTTGATCCTTCCCGCCAGAAGAAACTTGTATTGGGAGAT
CAACACCAGCTAGTGCGTTTCTCTATAAAGCCTCAGCGTATAGAACAGATTTCACATGCC
CAGAGGCTGTTGAGCAGGCTTCATGTGCGCTGCAGTCAGAGGCCACCTCTTTCTTTGTGG
GCCGGATGGGTCCTTGAGTGTCCTCTCTTCAAAAACTTCATCATCTTCCTGGTCTTTTTG
AATACGATCATATTGATGGTTGAAATAGAATTGCTGGAATCCACAAATACCAAACTATGG
CCATTGAAGCTGACCTTGGAGGTGGCAGCTTGGTTTATCTTGCTTATTTTCATCCTGGAG
ATCCTTCTTAAGTGGCTATCCAACTTTTCTGTTTTCTGGAAGAGTGCCTGGAATGTCTTT
GACTTTGTTGTTACCATGTTGTCCCTGCTTCCCGAGGTTGTGGTATTGGTAGGGGTAACA
GGCCAATCGGTGTGGCTTCAGCTTCTGAGGATCTGCCGGGTGCTGAGGTCTCTCAAACTC
CTTGCACAATTCCGTCAAATTCAAATTATTATTTTGGTCCTGGTCAGGGCCCTCAAGAGC
ATGACCTTCCTCTTGATGTTGCTGCTCATCTTCTTCTACATTTTTGCTGTGACTGGTGTC
TACGTCTTCTCAGAGTACACCCGTTCACCTCGTCAGGACCTGGAGTACCATGTGTTCTTC
TCGGACCTCCCGAATTCCCTGGTAACAGTGTTCATTCTCTTCACCTTGGATCATTGGTAT
GCACTGCTTCAGGACGTCTGGAAGGTGCCTGAAGTCAGTCGCATCTTCAGCAGCATCTAT
TTCATCCTTTGGTTGTTGCTTGGCTCCATTATCTTTCGAAGTATCATAGTAGCCATGATG
GTTACTAACTTTCAGAATATCAGGAAAGAGCTGAATGAGGAGATGGCGCGTCGGGAGGTT
CAGCTCAAAGCTGACATGTTCAAGCGGCAGATCATCCAGAGGAGAAAAAACATGTCACAT
GAAGCACTGACGTCAAGCCATAGCAAAATAGAGGACAGTTCAAGAGGAGCTAGTCAACAA
AGGGAAAGTTTGGACTTATCAGAAGTGTCTGAAGTAGAGTCTAATTATGGTGCCACTGAA
GAGGATTTAATAACATCTGCATCAAAAACAGAAGAGACCTTGTCAAAAAAGAGAGAGTAC
CAGTCTTCCTCCTGTGTCTCCTCCACATCCTCTTCCTATTCTTCCTCTTCTGAATCCAGA
TTTTCTGAATCTATTGGTCGTTTGGACTGGGAGACTCTTGTGCACGAAAATCTGCCCGGG
CTAATGGAAATGGATCAGGATGACCGTGTTTGGCCCAGAGACTCACTCTTCCGATATTTT
GAGTTGCTAGAAAAGCTTCAGTATAACCTAGAGGAACGTAAGAAGTTACAAGAGTTTGCA
GTGCAGGCACTGATGAACTTGGAAGACAAGTAA
Protein Properties
Number of Residues 530
Molecular Weight 62040.6
Theoretical pI 7.33
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["113-133", "146-166", "179-199", "206-226", "243-263", "321-341"]
Protein Sequence
>Cation channel sperm-associated protein 2
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE
EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG
LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
GenBank ID Protein 26051223
UniProtKB/Swiss-Prot ID Q96P56
UniProtKB/Swiss-Prot Entry Name CTSR2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_172095.1
GeneCard ID CATSPER2
GenAtlas ID CATSPER2
HGNC ID HGNC:18810
References
General References Not Available