Cannabis Compound Database: Showing Protein Cation channel sperm-associated protein 2 (CDBP02853)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02853

Secondary Accession Numbers

Not Available

Name

Cation channel sperm-associated protein 2

Description

Not Available

Synonyms

CatSper2

Gene Name

CATSPER2

Protein Type

Transporter

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization

GO Classification

Component
membrane
cell part
Function
ion transmembrane transporter activity
transporter activity
ion channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport

Cellular Location

Multi-pass membrane protein
Cell projection
cilium
flagellum membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

15q15.3

SNPs

CATSPER2

Gene Sequence

>1593 bp
ATGGCCGCTTACCAACAAGAAGAGCAGATGCAGCTTCCCCGAGCTGATGCCATTCGTTCA
CGTCTCATCGATACTTTCTCTCTCATTGAGCATTTGCAAGGCTTGAGCCAAGCTGTGCCG
CGGCACACTATCAGGGAGTTACTTGATCCTTCCCGCCAGAAGAAACTTGTATTGGGAGAT
CAACACCAGCTAGTGCGTTTCTCTATAAAGCCTCAGCGTATAGAACAGATTTCACATGCC
CAGAGGCTGTTGAGCAGGCTTCATGTGCGCTGCAGTCAGAGGCCACCTCTTTCTTTGTGG
GCCGGATGGGTCCTTGAGTGTCCTCTCTTCAAAAACTTCATCATCTTCCTGGTCTTTTTG
AATACGATCATATTGATGGTTGAAATAGAATTGCTGGAATCCACAAATACCAAACTATGG
CCATTGAAGCTGACCTTGGAGGTGGCAGCTTGGTTTATCTTGCTTATTTTCATCCTGGAG
ATCCTTCTTAAGTGGCTATCCAACTTTTCTGTTTTCTGGAAGAGTGCCTGGAATGTCTTT
GACTTTGTTGTTACCATGTTGTCCCTGCTTCCCGAGGTTGTGGTATTGGTAGGGGTAACA
GGCCAATCGGTGTGGCTTCAGCTTCTGAGGATCTGCCGGGTGCTGAGGTCTCTCAAACTC
CTTGCACAATTCCGTCAAATTCAAATTATTATTTTGGTCCTGGTCAGGGCCCTCAAGAGC
ATGACCTTCCTCTTGATGTTGCTGCTCATCTTCTTCTACATTTTTGCTGTGACTGGTGTC
TACGTCTTCTCAGAGTACACCCGTTCACCTCGTCAGGACCTGGAGTACCATGTGTTCTTC
TCGGACCTCCCGAATTCCCTGGTAACAGTGTTCATTCTCTTCACCTTGGATCATTGGTAT
GCACTGCTTCAGGACGTCTGGAAGGTGCCTGAAGTCAGTCGCATCTTCAGCAGCATCTAT
TTCATCCTTTGGTTGTTGCTTGGCTCCATTATCTTTCGAAGTATCATAGTAGCCATGATG
GTTACTAACTTTCAGAATATCAGGAAAGAGCTGAATGAGGAGATGGCGCGTCGGGAGGTT
CAGCTCAAAGCTGACATGTTCAAGCGGCAGATCATCCAGAGGAGAAAAAACATGTCACAT
GAAGCACTGACGTCAAGCCATAGCAAAATAGAGGACAGTTCAAGAGGAGCTAGTCAACAA
AGGGAAAGTTTGGACTTATCAGAAGTGTCTGAAGTAGAGTCTAATTATGGTGCCACTGAA
GAGGATTTAATAACATCTGCATCAAAAACAGAAGAGACCTTGTCAAAAAAGAGAGAGTAC
CAGTCTTCCTCCTGTGTCTCCTCCACATCCTCTTCCTATTCTTCCTCTTCTGAATCCAGA
TTTTCTGAATCTATTGGTCGTTTGGACTGGGAGACTCTTGTGCACGAAAATCTGCCCGGG
CTAATGGAAATGGATCAGGATGACCGTGTTTGGCCCAGAGACTCACTCTTCCGATATTTT
GAGTTGCTAGAAAAGCTTCAGTATAACCTAGAGGAACGTAAGAAGTTACAAGAGTTTGCA
GTGCAGGCACTGATGAACTTGGAAGACAAGTAA

Protein Properties

Number of Residues

530

Molecular Weight

62040.6

Theoretical pI

7.33

Pfam Domain Function

Ion_trans (PF00520 )

Signals

["None"]

Transmembrane Regions

["113-133", "146-166", "179-199", "206-226", "243-263", "321-341"]

Protein Sequence

>Cation channel sperm-associated protein 2
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE
EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG
LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK

External Links

GenBank ID Protein

26051223

UniProtKB/Swiss-Prot ID

Q96P56

UniProtKB/Swiss-Prot Entry Name

CTSR2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_172095.1

GeneCard ID