Showing Protein Cation channel sperm-associated protein 1 (CDBP02852)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02852
Secondary Accession Numbers Not Available
Name Cation channel sperm-associated protein 1
Description Not Available
Synonyms
  1. CatSper1
  2. hCatSper
Gene Name CATSPER1
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization
GO Classification
Component
membrane
cell part
Function
ion transmembrane transporter activity
transporter activity
ion channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Multi-pass membrane protein
  2. Cell projection
  3. cilium
  4. flagellum membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q12.1
SNPs CATSPER1
Gene Sequence 
>2343 bp
ATGGATCAAAACTCAGTGCCTGAAAAGGCTCAGAATGAGGCAGACACCAATAACGCAGAT
AGGTTCTTTCGCTCTCACTCATCACCCCCACACCACAGGCCAGGCCACAGCAGAGCTCTC
CACCATTACGAGTTGCACCATCACGGCGTGCCCCACCAACGTGGTGAATCTCACCACCCT
CCGGAGTTCCAAGACTTCCACGACCAAGCCTTGTCCTCCCATGTCCACCAATCTCACCAC
CACAGCGAGGCACGGAATCACGGCAGAGCCCATGGCCCCACAGGCTTTGGTCTGGCTCCC
TCTCAAGGCGCCGTCCCCTCCCACCGTTCCTACGGTGAGGACTACCATGATGAGCTCCAA
CGTGATGGCAGGAGGCATCATGATGGGTCCCAATACGGTGGGTTCCATCAGCAGAGTGAC
TCCCATTACCATAGGGGGTCTCACCATGGCAGACCCCAATATCTCGGTGAGAATTTATCC
CACTATTCCTCTGGCGTGCCCCACCACGGTGAGGCTTCCCACCATGGTGGGTCCTACCTC
CCCCATGGACCCAATCCCTACAGTGAGTCCTTCCACCACAGCGAGGCTTCCCACCTTAGC
GGGCTCCAACACGATGAGTCCCAGCATCACCAAGTCCCCCACCGTGGCTGGCCCCACCAT
CACCAAGTCCACCACCATGGCAGGTCCCGTCATCATGAAGCCCACCAGCATGGAAAGTCT
CCTCATCACGGAGAGACCATTTCCCCTCATTCCTCTGTGGGGTCCTACCAGCGTGGGATA
TCTGACTATCACAGCGAGTACCACCAAGGTGATCACCACCCCAGTGAGTACCACCATGGC
GACCATCCCCACCACACACAGCACCACTACCACCAGACCCACCGGCACCGAGACTACCAT
CAGCACCAAGACCACCACGGCGCGTATCATTCCAGTTACCTCCATGGCGACTACGTCCAG
AGCACTTCCCAACTCTCTATCCCACACACATCCCGGAGCCTGATTCACGATGCCCCCGGC
CCTGCTGCTTCTCGTACAGGAGTCTTCCCCTATCACGTAGCACACCCACGGGGCTCGGCT
CACAGCATGACTCGGTCCTCCAGCACAATCCGCTCACGTGTCACCCAGATGTCCAAAAAA
GTCCATACCCAGGATATCTCCACCAAACATTCAGAAGACTGGGGCAAAGAAGAAGGGCAA
TTTCAGAAACGCAAAACCGGCAGGCTCCAGCGGACCCGCAAGAAGGGACACTCTACCAAT
CTCTTCCAGTGGCTGTGGGAAAAGCTAACCTTCCTCATTCAGGGCTTCCGGGAAATGATC
CGGAACCTGACCCAATCCTTGGCCTTTGAAACTTTCATCTTCTTCGTTGTCTGCCTCAAC
ACCGTCATGCTGGTGGCCCAGACCTTCGCTGAAGTCGAGATCCGGGGCGAGTGGTACTTC
ATGGCCTTGGACTCCATATTCTTCTGCATCTACGTGGTGGAAGCCCTGCTCAAGATCATC
GCCCTGGGCCTCTCGTACTTCTTTGACTTCTGGAACAATTTGGACTTCTTCATTATGGCC
ATGGCCGTGCTGGACTTCTTGCTGATGCAGACCCACTCCTTCGCCATCTACCACCAAAGC
CTCTTCCGGATCCTCAAGGTCTTCAAGAGCCTGCGGGCCCTGAGGGCAATCCGGGTCCTG
CGGAGGCTCAGCTTCCTGACCAGCGTCCAGGAAGTGACAGGGACCCTGGGCCAGTCCTTG
CCGTCCATCGCAGCCATCCTCATCCTCATGTTTACCTGCCTCTTCCTCTTCTCCGCGGTC
CTCCGGGCACTGTTCCGCAAATCTGACCCCAAGCGCTTCCAGAACATCTTCACCACCATC
TTCACCCTCTTCACCTTGCTCACGCTGGATGACTGGTCCCTCATCTACATGGACAGCCGT
GCCCAGGGCGCCTGGTACATCATTCCCATCCTCATAATTTACATCATCATCCAGTACTTC
ATCTTCCTCAACCTGGTGATTACTGTCCTGGTGGATAGCTTCCAGACGGCGCTGTTCAAA
GGCCTTGAGAAAGCGAAGCAGGAGAGGGCCGCCCGGATCCAAGAGAAGCTGCTGGAAGAC
TCACTGACGGAGCTCAGAGCTGCAGAGCCCAAAGAGGTGGCGAGTGAAGGCACCATGCTG
AAGCGGCTCATCGAGAAAAAGTTTGGGACCATGACTGAGAAGCAGCAGGAGCTCCTGTTC
CATTACCTGCAGCTGGTGGCAAGCGTGGAGCAGGAGCAGCAGAAGTTCCGCTCCCAGGCA
GCCGTCATCGATGAGATTGTGGACACCACATTTGAGGCTGGAGAAGAGGACTTCAGGAAT
TGA
Protein Properties
Number of Residues 780
Molecular Weight 90090.2
Theoretical pI 7.74
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["446-466", "486-506", "516-536", "542-562", "580-600", "647-667"]
Protein Sequence 
>Cation channel sperm-associated protein 1
MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP
PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ
RDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL
PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS
PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH
QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA
HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN
LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF
MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS
LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV
LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYF
IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML
KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
GenBank ID Protein 16076816
UniProtKB/Swiss-Prot ID Q8NEC5
UniProtKB/Swiss-Prot Entry Name CTSR1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF407333
GeneCard ID CATSPER1
GenAtlas ID CATSPER1
HGNC ID HGNC:17116
References
General References Not Available