| Identification |
|---|
| HMDB Protein ID
| CDBP02849 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calsyntenin-1 |
| Description
| Not Available |
| Synonyms
|
- Alc-alpha
- Alcadein-alpha
- Alzheimer-related cadherin-like protein
- C-terminal fragment 1-alpha
- CTF1-alpha
- Non-classical cadherin XB31alpha
- SAlc-alpha
- Soluble Alc-alpha
|
| Gene Name
| CLSTN1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Nucleus
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Single-pass type I membrane protein
- Cell junction
- synapse
- Cell projection
- postsynaptic cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.22 |
| SNPs
| CLSTN1 |
| Gene Sequence
|
>2946 bp
ATGCTGCGCCGCCCCGCTCCCGCGCTGGCCCCGGCCGCCCGGCTGCTGCTGGCCGGGCTG
CTGTGCGGCGGCGGGGTCTGGGCCGCGCGAGTTAACAAGCACAAGCCCTGGCTGGAGCCC
ACCTACCACGGCATAGTCACAGAGAACGACAACACCGTGCTCCTCGACCCCCCACTGATC
GCGCTGGATAAAGATGCGCCTCTGCGATTTGCAGAGAGTTTTGAGGTGACAGTCACCAAA
GAAGGTGAGATTTGTGGATTTAAAATTCACGGGCAGAATGTCCCCTTTGATGCAGTGGTA
GTGGATAAATCCACTGGTGAGGGAGTCATTCGCTCCAAAGAGAAACTGGACTGTGAGCTG
CAGAAAGACTATTCATTCACCATCCAGGCCTATGATTGTGGGAAGGGACCTGATGGCACC
AACGTGAAAAAGTCTCATAAAGCAACTGTTCATATTCAGGTGAACGACGTGAATGAGTAC
GCGCCCGTGTTCAAGGAGAAGTCCTACAAAGCCACGGTCATCGAGGGGAAGCAGTACGAC
AGCATTTTGAGGGTGGAGGCCGTGGATGCCGACTGCTCCCCTCAGTTCAGCCAGATTTGC
AGCTACGAAATCATCACTCCAGACGTGCCCTTTACTGTTGACAAAGATGGTTATATAAAA
AACACAGAGAAATTAAACTACGGGAAAGAACATCAATATAAGCTGACCGTCACTGCCTAT
GACTGTGGGAAGAAAAGAGCCACAGAAGATGTTTTGGTGAAGATCAGCATTAAGCCCACC
TGCACCCCTGGGTGGCAAGGATGGAACAACAGGATTGAGTATGAGCCGGGCACCGGCGCG
TTGGCCGTCTTTCCAAATATCCACCTGGAGACATGTGACGAGCCAGTCGCCTCAGTACAG
GCCACAGTGGAGCTAGAAACCAGCCACATAGGGAAAGGCTGCGACCGAGACACCTACTCA
GAGAAGTCCCTCCACCGGCTCTGTGGTGCGGCCGCGGGCACTGCCGAGCTGCTGCCATCC
CCGAGTGGATCCCTCAACTGGACCATGGGCCTGCCCACCGACAATGGCCACGACAGCGAC
CAGGTGTTTGAGTTCAACGGCACCCAGGCAGTGAGGATCCCGGATGGCGTCGTGTCGGTC
AGCCCCAAAGAGCCGTTCACCATCTCGGTGTGGATGAGACATGGGCCATTCGGCAGGAAG
AAGGAGACAATTCTTTGCAGTTCTGATAAAACAGATATGAATCGGCACCACTACTCCCTC
TATGTCCACGGGTGCCGGCTGATCTTCCTCTTCCGTCAGGATCCTTCTGAGGAGAAGAAA
TACAGACCTGCAGAGTTCCACTGGAAGTTGAATCAGGTCTGTGATGAGGAATGGCACCAC
TACGTCCTCAATGTAGAATTCCCGAGTGTGACTCTCTATGTGGATGGCACGTCCCACGAG
CCCTTCTCTGTGACTGAGGATTACCCGCTCCATCCATCCAAGATAGAAACTCAGCTCGTG
GTGGGGGCTTGCTGGCAAGAGTTTTCAGGAGTTGAAAATGACAATGAAACTGAGCCTGTG
ACTGTGGCCTCTGCAGGTGGCGACCTGCACATGACCCAGTTTTTCCGAGGCAATCTGGCT
GGCTTAACTCTCCGTTCCGGGAAACTCGCGGATAAGAAGGTGATCGACTGTCTGTATACC
TGCAAGGAGGGGCTGGACCTGCAGGTCCTCGAAGACAGTGGCAGAGGCGTGCAGATCCAA
GCACACCCCAGCCAGTTGGTATTGACCTTGGAGGGAGAAGACCTCGGGGAATTGGATAAG
GCCATGCAGCACATCTCGTACCTGAACTCCCGGCAGTTCCCCACGCCCGGAATTCGCAGA
CTCAAAATCACCAGCACAATCAAGTGTTTTAACGAGGCCACCTGCATTTCGGTCCCCCCG
GTAGATGGCTACGTGATGGTTTTACAGCCCGAGGAGCCCAAGATCAGCCTGAGTGGCGTC
CACCATTTTGCCCGAGCAGCTTCTGAATTTGAAAGCTCAGAAGGGGTGTTCCTTTTCCCT
GAGCTTCGCATCATCAGCACCATCACGAGAGAAGTGGAGCCTGAAGGGGACGGGGCTGAG
GACCCCACAGTTCAAGAATCACTGGTGTCCGAGGAGATCGTGCACGACCTGGATACCTGT
GAGGTCACGGTGGAGGGAGAGGAGCTGAACCACGAGCAGGAGAGCCTGGAGGTGGACATG
GCCCGCCTGCAGCAGAAGGGCATTGAAGTGAGCAGCTCTGAACTGGGCATGACCTTCACA
GGCGTGGACACCATGGCCAGCTACGAGGAGGTTTTGCACCTGCTGCGCTATCGGAACTGG
CATGCCAGGTCCTTGCTTGACCGGAAGTTTAAGCTCATCTGCTCAGAGCTGAATGGCCGC
TACATCAGCAACGAATTTAAGGTGGAGGTGAATGTAATCCACACGGCCAACCCCATGGAA
CACGCCAACCACATGGCTGCCCAGCCACAGTTCGTGCACCCGGAACACCGCTCCTTTGTT
GACCTGTCAGGCCACAACCTGGCCAACCCCCACCCGTTCGCAGTCGTCCCCAGCACTGCG
ACAGTTGTGATCGTGGTGTGCGTCAGCTTCCTGGTGTTCATGATTATCCTGGGGGTATTT
CGGATCCGGGCCGCACATCGGCGGACCATGCGGGATCAGGACACCGGGAAGGAGAACGAG
ATGGACTGGGACGACTCTGCCCTGACCATCACCGTCAACCCCATGGAGACCTATGAGGAC
CAGCACAGCAGTGAGGAGGAGGAGGAAGAGGAAGAGGAAGAGGAAAGCGAGGACGGCGAA
GAAGAGGATGACATCACCAGCGCCGAGTCGGAGAGCAGCGAGGAGGAGGAGGGGGAGCAG
GGCGACCCCCAGAACGCAACCCGGCAGCAGCAGCTGGAGTGGGATGACTCCACCCTCAGC
TACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 981 |
| Molecular Weight
| 109792.0 |
| Theoretical pI
| 4.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calsyntenin-1
MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI
ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL
QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD
SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY
DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ
ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD
QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL
YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE
PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA
GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK
AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV
HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC
EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW
HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV
DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE
MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ
GDPQNATRQQQLEWDDSTLSY
|
| External Links |
|---|
| GenBank ID Protein
| 57242757 |
| UniProtKB/Swiss-Prot ID
| O94985 |
| UniProtKB/Swiss-Prot Entry Name
| CSTN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001009566.1 |
| GeneCard ID
| CLSTN1 |
| GenAtlas ID
| CLSTN1 |
| HGNC ID
| HGNC:17447 |
| References |
|---|
| General References
| Not Available |