Identification
HMDB Protein ID CDBP02844
Secondary Accession Numbers Not Available
Name Calpain small subunit 2
Description Not Available
Synonyms
  1. CSS2
  2. Calcium-dependent protease small subunit 2
Gene Name CAPNS2
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Cellular Location
  1. Cell membrane
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16q12.2
SNPs CAPNS2
Gene Sequence
>747 bp
ATGTTTCTTGCAAAGGCTCTATTGGAAGGAGCAGATCGAGGTCTTGGAGAAGCTCTTGGA
GGCCTCTTTGGAGGAGGTGGTCAGAGAAGAGAAGGAGGAGGAAGAAATATTGGAGGGATA
GTTGGAGGAATTGTGAATTTTATCAGTGAGGCTGCAGCAGCTCAGTATACTCCAGAACCG
CCTCCCACTCAGCAGCATTTCACCAGTGTGGAGGCCTCACAAAGTGAGGAAGTTAGGCGA
TTTCGGCAACAATTTACACAGCTGGCTGGACCAGACATGGAGGTGGGTGCCACTGATCTG
ATGAATATTCTCAACAAAGTCCTTTCTAAGCACAAAGATCTTAAGACTGACGGTTTTAGT
CTTGACACCTGCCGGAGCATTGTGTCTGTCATGGACAGTGACACGACTGGTAAGCTGGGC
TTTGAAGAATTTAAGTATCTGTGGAACAACATCAAGAAATGGCAGTGTGTTTATAAGCAG
TATGACAGGGACCATTCTGGGTCTCTGGGAAGTTCTCAGCTGCGGGGAGCTCTGCAGGCC
GCAGGCTTCCAGCTAAATGAACAACTTTACCAAATGATTGTCCGCCGGTATGCTAATGAA
GATGGAGATATGGATTTTAACAATTTCATCAGCTGCTTGGTCCGCCTGGATGCCATGTTT
CGTGCCTTCAAGTCTCTGGATAGAGATAGAGATGGCCTGATTCAAGTGTCTATCAAAGAA
TGGCTGCAGTTGACCATGTATTCCTGA
Protein Properties
Number of Residues 248
Molecular Weight 27660.0
Theoretical pI 5.41
Pfam Domain Function Not Available
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Calpain small subunit 2
MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEP
PPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFS
LDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQA
AGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKE
WLQLTMYS
GenBank ID Protein 15667255
UniProtKB/Swiss-Prot ID Q96L46
UniProtKB/Swiss-Prot Entry Name CPNS2_HUMAN
PDB IDs Not Available
GenBank Gene ID AY052551
GeneCard ID CAPNS2
GenAtlas ID CAPNS2
HGNC ID HGNC:16371
References
General References Not Available