Cannabis Compound Database: Showing Protein Cyclic nucleotide-gated cation channel alpha-4 (CDBP02831)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02831

Secondary Accession Numbers

Not Available

Name

Cyclic nucleotide-gated cation channel alpha-4

Description

Not Available

Synonyms

CNG channel alpha-4
CNG-4
CNG4
Cyclic nucleotide-gated channel alpha-4

Gene Name

CNGA4

Protein Type

Transporter

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection

GO Classification

Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport

Cellular Location

Membrane
Multi-pass membrane protein (Potential)

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11p15.4

SNPs

CNGA4

Gene Sequence

>1728 bp
ATGAGCCAGGACACCAAAGTGAAGACAACAGAGTCCAGTCCCCCAGCCCCATCCAAGGCC
AGGAAGTTGCTGCCTGTCCTGGACCCATCTGGGGATTACTACTACTGGTGGCTGAACACA
ATGGTCTTCCCAGTCATGTATAACCTCATCATCCTCGTGTGCAGAGCCTGCTTCCCCGAC
TTGCAGCACGGTTATCTGGTGGCCTGGTTGGTGCTGGACTACACGAGTGACCTGCTATAC
CTACTAGACATGGTGGTGCGCTTCCACACAGGATTCTTGGAACAGGGCATCCTGGTGGTG
GACAAGGGTAGGATCTCGAGTCGCTACGTTCGCACCTGGAGTTTCTTCTTGGACCTGGCT
TCCCTGATGCCCACAGATGTGGTCTACGTGCGGCTGGGCCCGCACACACCCACCCTGAGG
CTGAACCGCTTTCTCCGCGCGCCCCGCCTCTTCGAGGCCTTCGACCGCACAGAGACCCGC
ACAGCTTACCCAAATGCCTTTCGCATTGCCAAGCTGATGCTTTACATTTTTGTCGTCATC
CATTGGAACAGCTGCCTATACTTTGCCCTATCCCGGTACCTGGGCTTCGGGCGTGACGCA
TGGGTGTACCCGGACCCCGCGCAGCCTGGCTTTGAGCGCCTGCGGCGCCAGTACCTCTAT
AGCTTTTACTTCTCCACGCTGATACTGACTACAGTGGGCGATACACCGCCGCCAGCCAGG
GAAGAAGAGTACCTCTTCATGGTGGGCGACTTCCTGCTGGCCGTCATGGGTTTCGCCACC
ATCATGGGTAGCATGAGCTCTGTCATCTACAACATGAACACTGCAGATGCGGCTTTCTAC
CCAGATCATGCACTGGTGAAGAAGTACATGAAGCTGCAGCACGTCAACCGCAAGCTGGAG
CGGCGAGTTATTGACTGGTATCAGCACCTGCAGATCAACAAGAAGATGACCAACGAGGTA
GCCATCTTACAGCACTTGCCTGAGCGGCTGCGGGCAGAAGTGGCTGTGTCTGTGCACCTG
TCCACTCTGAGCCGGGTGCAGATCTTTCAGAACTGTGAGGCCAGCCTGCTGGAGGAGCTG
GTGCTGAAGCTGCAGCCCCAGACCTACTCACCAGGTGAATATGTATGCCGCAAAGGAGAC
ATTGGCCAAGAGATGTACATCATCCGAGAGGGTCAACTGGCCGTGGTGGCAGATGATGGT
ATCACACAGTATGCTGTGCTCGGTGCAGGGCTCTACTTTGGGGAGATCAGCATCATCAAC
ATCAAAGGGAACATGTCTGGGAACCGCCGCACAGCCAACATCAAGAGCCTAGGTTATTCA
GACCTATTCTGCCTGAGCAAGGAGGACCTGCGGGAGGTGCTGAGCGAGTATCCACAAGCA
CAGACCATCATGGAGGAGAAAGGACGTGAGATCCTGCTGAAAATGAACAAGTTGGACGTG
AATGCTGAGGCAGCTGAGATCGCCCTGCAGGAGGCCACAGAGTCCCGGCTACGAGGCCTA
GACCAGCAGCTGGATGATCTACAGACCAAGTTTGCTCGCCTCCTGGCTGAGCTGGAGTCC
AGCGCACTTAAGATTGCTTACCGCATTGAACGGCTGGAGTGGCAGACTCGAGAGTGGCCA
ATGCCCGAGGACCTGGCTGAGGCTGATGACGAGGGTGAGCCTGAGGAGGGAACTTCCAAA
GATGAAGAGGGCAGGGCCAGCCAGGAGGGACCCCCAGGTCCAGAGTGA

Protein Properties

Number of Residues

575

Molecular Weight

65968.2

Theoretical pI

5.32

Pfam Domain Function

cNMP_binding (PF00027 )
Ion_trans (PF00520 )

Signals

["None"]

Transmembrane Regions

["34-54", "66-86", "113-133", "169-189", "218-234", "245-265"]

Protein Sequence

>Cyclic nucleotide-gated cation channel alpha-4
MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPD
LQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLA
SLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI
HWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAR
EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLE
RRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEEL
VLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIIN
IKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDV
NAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWP
MPEDLAEADDEGVPEEGTSKDEEGRASQEGPPGPE

External Links

GenBank ID Protein

82617546

UniProtKB/Swiss-Prot ID

Q8IV77

UniProtKB/Swiss-Prot Entry Name

CNGA4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001037329

GeneCard ID