| Identification |
|---|
| HMDB Protein ID
| CDBP02828 |
| Secondary Accession Numbers
| Not Available |
| Name
| Clathrin heavy chain 2 |
| Description
| Not Available |
| Synonyms
|
- CLH-22
- Clathrin heavy chain on chromosome 22
|
| Gene Name
| CLTCL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network |
| GO Classification
|
| Component |
| membrane coat |
| clathrin coat of coated pit |
| clathrin coat |
| clathrin vesicle coat |
| clathrin coat of trans-golgi network vesicle |
| macromolecular complex |
| protein complex |
| Function |
| binding |
| structural molecule activity |
| protein binding |
| Process |
| intracellular protein transport |
| vesicle-mediated transport |
| establishment of localization |
| transport |
| protein transport |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Membrane
- Cytoplasmic side
- Cytoplasmic side
- Cytoplasmic vesicle membrane
- coated pit
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q11.2|22q11.21 |
| SNPs
| CLTCL1 |
| Gene Sequence
|
>4923 bp
ATGGCGCAGATCCTCCCTGTTCGCTTTCAGGAGCACTTCCAGCTCCAAAACCTTGGAATT
AATCCAGCTAACATTGGATTCAGCACACTGACCATGGAATCTGACAAGTTCATATGTATC
CGAGAGAAAGTTGGTGAGCAGGCACAGGTCACGATCATTGACATGAGTGACCCAATGGCT
CCGATCCGACGGCCTATCTCTGCAGAGAGTGCCATCATGAATCCAGCCTCTAAGGTGATA
GCTCTGAAAGCTGGGAAGACACTTCAGATCTTTAATATTGAGATGAAGAGTAAAATGAAG
GCTCATACTATGGCAGAAGAAGTGATTTTCTGGAAATGGGTTTCTGTGAACACTGTTGCC
TTGGTGACCGAGACCGCGGTCTACCACTGGAGCATGGAAGGTGACTCCCAGCCCATGAAG
ATGTTTGATAGACATACCAGTCTGGTGGGCTGCCAGGTGATTCACTACCGGACTGATGAG
TACCAGAAGTGGCTGCTGCTCGTAGGCATCTCGGCTCAGCAAAACCGTGTGGTTGGAGCA
ATGCAGCTCTACTCTGTGGATAGGAAGGTTTCACAACCCATAGAAGGCCATGCTGCGGCT
TTTGCAGAGTTCAAGATGGAGGGGAATGCCAAGCCTGCCACCCTTTTCTGCTTTGCTGTA
CGTAATCCCACAGGAGGCAAGTTGCACATCATTGAAGTTGGACAGCCTGCAGCGGGAAAC
CAACCTTTTGTAAAGAAAGCAGTAGATGTGTTTTTTCCTCCAGAGGCACAGAATGATTTT
CCAGTGGCTATGCAGATTGGAGCTAAACATGGTGTTATTTACTTGATCACAAAGTATGGC
TATCTTCATCTGTACGACCTAGAGTCTGGCGTGTGCATCTGCATGAACCGTATTAGTGCT
GACACAATATTTGTCACTGCTCCACACAAACCAACCTCTGGAATTATTGGTGTCAACAAA
AAGGGACAGGTACTGTCAGTTTGTGTTGAGGAAGATAACATTGTGAATTATGCAACCAAC
GTGCTTCAGAATCCAGACCTTGGTCTGCGTTTGGCCGTTCGTAGTAACCTGGCTGGGGCA
GAGAAGTTGTTTGTGAGAAAATTCAATACCCTCTTTGCACAGGGCAGCTATGCTGAAGCC
GCCAAAGTTGCAGCGTCTGCACCAAAGGGAATCCTGCGTACCAGAGAGACGGTCCAGAAA
TTCCAGAGTATACCCGCTCAGTCTGGCCAGGCTTCTCCATTGCTGCAGTACTTCGGAATC
CTGCTCGACCAGGGTCAGCTCAATAAACTTGAATCCTTAGAACTTTGCCATCTGGTTCTT
CAGCAGGGGCGTAAGCAACTCCTAGAGAAGTGGCTGAAAGAAGATAAGCTGGAGTGCTCA
GAGGAGCTCGGAGACTTGGTCAAAACCACTGACCCCATGCTCGCTCTGAGTGTGTACCTT
CGGGCAAATGTGCCAAGCAAAGTGATCCAGTGTTTTGCAGAAACAGGCCAATTCCAGAAA
ATTGTGCTCTATGCCAAAAAGGTTGGGTACACCCCAGACTGGATCTTTCTGCTGAGGGGT
GTAATGAAGATCAGTCCGGAACAGGGCCTGCAGTTTTCTCGAATGCTAGTGCAGGACGAG
GAGCCGCTGGCCAACATTAGCCAGATTGTGGACATTTTCATGGAAAACAGTTTAATTCAG
CAGTGTACTTCCTTCTTATTGGATGCCTTGAAGAATAATCGCCCAGCTGAGGGACTCCTG
CAGACATGGCTGTTGGAGATGAACCTTGTTCATGCACCCCAGGTTGCAGATGCCATCCTT
GGAAATAAAATGTTTACTCATTACGACCGGGCCCACATTGCCCAGCTCTGTGAGAAGGCA
GGCCTCCTGCAGCAAGCACTGGAGCACTACACCGACCTCTATGACATCAAGAGGGCTGTG
GTCCACACTCACCTCCTCAATCCCGAGTGGCTTGTCAATTTCTTTGGCTCCTTATCGGTG
GAGGATTCTGTGGAGTGTCTGCATGCCATGCTGTCTGCTAACATCAGACAGAACCTTCAG
CTGTGTGTGCAGGTGGCCTCTAAGTACCACGAGCAGCTGGGCACGCAGGCCCTGGTGGAG
CTCTTTGAATCCTTCAAGAGTTACAAAGGCCTCTTCTACTTCCTGGGCTCAATCGTGAAC
TTCAGCCAAGACCCAGATGTGCATCTGAAATACATTCAGGCTGCCTGTAAGACAGGGCAG
ATCAAGGAGGTGGAGAGGATATGCCGAGAGAGCAGCTGCTACAACCCAGAGCGTGTGAAG
AACTTCCTGAAGGAGGCCAAGCTCACAGACCAGCTTCCCCTCATCATCGTGTGTGATCGT
TTTGGCTTTGTCCATGACCTTGTCCTATATTTATACCGCAACAACCTGCAGAGGTACATT
GAGATCTACGTGCAGAAGGTCAACCCTAGCCGGACCCCAGCTGTGATTGGAGGGCTGCTT
GATGTGGATTGTTCTGAGGAAGTGATTAAACACTTAATCATGGCAGTGAGAGGACAGTTC
TCTACTGATGAGTTGGTGGCTGAAGTAGAAAAAAGAAATAGGCTCAAGCTGCTGCTTCCC
TGGCTGGAGTCCCAGATTCAGGAAGGCTGTGAGGAGCCTGCCACTCACAATGCACTGGCT
AAAATCTACATCGACAGCAACAACAGCCCCGAGTGCTTCCTGAGAGAGAATGCCTACTAT
GACAGCAGCGTGGTGGGCCGCTACTGTGAGAAGCGAGACCCCCATCTGGCCTGTGTTGCC
TATGAGCGGGGGCAGTGTGACCTTGAGCTCATCAAGGTGTGCAATGAGAATTCTCTGTTC
AAAAGCGAGGCCCGCTACCTGGTATGCAGAAAGGATCCGGAGCTCTGGGCTCACGTCCTT
GAGGAGACCAACCCATCCAGGAGACAGCTAATTGACCAGGTGGTACAGACAGCATTGTCA
GAAACACGGGATCCTGAAGAGATTTCGGTCACTGTCAAAGCCTTTATGACAGCCGACCTG
CCTAATGAACTGATTGAACTGCTGGAGAAGATAGTTCTGGATAACTCTGTCTTCAGCGAG
CACAGGAATCTACAGAATCTGTTGATCCTGACTGCCATCAAGGCAGACCGCACACGGGTC
ATGGAGTACATCAGCCGCCTGGACAACTATGACGCACTGGACATCGCGAGCATCGCTGTC
AGCAGCGCACTGTATGAGGAGGCCTTCACCGTTTTCCACAAGTTTGATATGAATGCCTCA
GCAATCCAGGTCCTGATCGAGCACATTGGAAACCTGGACCGGGCATATGAGTTTGCGGAG
AGATGCAATGAGCCTGCTGTGTGGAGTCAGCTGGCCCAAGCCCAGCTCCAGAAAGATTTG
GTGAAGGAAGCCATCAACTCCTATATCAGAGGGGACGACCCTTCCTCTTACCTGGAAGTT
GTTCAGTCAGCCAGCAGGAGCAACAACTGGGAGGATCTAGTTAAATTTCTGCAGATGGCC
AGGAAAAAGGGCCGTGAGTCCTATATAGAGACTGAACTTATTTTTGCCTTGGCTAAAACC
AGCCGTGTTTCTGAGCTAGAAGATTTTATTAATGGACCCAACAATGCCCACATCCAGCAG
GTTGGAGACCGCTGTTACGAGGAGGGAATGTACGAGGCTGCCAAGCTGCTCTATAGCAAT
GTTTCTAACTTTGCCCGCCTGGCTTCCACCTTGGTTCACCTCGGTGAGTATCAGGCAGCA
GTGGACAACAGCCGCAAGGCCAGCAGCACCCGGACGTGGAAGGAGGTGTGCTTTGCCTGC
ATGGATGGACAAGAGTTCCGCTTCGCACAGCTGTGTGGTCTTCACATCGTCATTCATGCA
GATGAGCTGGAGGAGCTGATGTGCTATTACCAGGATCGTGGCTACTTTGAGGAGCTGATC
TTGCTGTTGGAAGCGGCCCTGGGCCTGGAGCGGGCCCACATGGGCATGTTCACTGAGCTG
GCCATCCTCTACTCCAAATTCAAGCCACAGAAGATGCTGGAGCATCTGGAGCTTTTCTGG
TCCCGTGTCAACATCCCAAAGGTGCTGAGGGCTGCAGAGCAGGCACACCTGTGGGCTGAG
CTGGTGTTCCTCTATGACAAGTACGAGGAGTATGACAATGCTGTGCTCACCATGATGAGC
CACCCCACTGAGGCCTGGAAGGAGGGTCAGTTCAAGGACATCATTACCAAGGTTGCCAAC
GTCGAGCTCTGTTACAGAGCCCTGCAGTTCTATTTGGATTACAAACCACTGCTCATCAAT
GACCTGCTGCTGGTGCTTTCACCCCGGCTGGACCACACCTGGACAGTCAGTTTCTTTTCA
AAGGCAGGTCAGCTGCCCCTGGTGAAGCCTTACCTGCGGTCAGTCCAGAGCCACAACAAC
AAGAGTGTGAATGAGGCACTCAACCACCTGCTGACAGAGGAGGAGGACTATCAGGGCTTA
AGGGCATCTATCGATGCCTATGACAACTTTGACAACATCAGCCTGGCTCAGCAGCTGGAG
AAGCATCAGCTGATGGAGTTCAGGTGCATTGCGGCCTATCTGTACAAGGGCAATAACTGG
TGGGCCCAGAGCGTGGAGCTCTGCAAGAAGGATCATCTCTACAAGGATGCCATGCAGCAT
GCTGCAGAGTCGCGGGATGCTGAGCTGGCCCAGAAGTTGCTGCAGTGGTTCCTGGAGGAA
GGCAAGAGGGAGTGCTTCGCAGCTTGTCTCTTCACCTGCTATGACCTGCTTCGCCCAGAC
ATGGTGCTTGAGCTGGCCTGGAGGCACAACCTCGTGGACTTGGCCATGCCCTACTTCATC
CAGGTGATGAGGGAGTACCTGAGCAAGGTGGACAAACTGGATGCCTTGGAGAGTCTGCGC
AAGCAAGAGGAGCATGTGACAGAGCCTGCCCCTCTCGTGTTTGATTTTGATGGGCATGAA
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 1640 |
| Molecular Weight
| 187028.2 |
| Theoretical pI
| 5.67 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Clathrin heavy chain 2
MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMA
PIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVA
LVTETAVYHWSMEGDSQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGN
QPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISA
DTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGA
EKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGI
LLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYL
RANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDE
EPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAIL
GNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSV
EDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVN
FSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDR
FGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQF
STDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYY
DSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVL
EETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSE
HRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNAS
AIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEV
VQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQ
VGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFAC
MDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTEL
AILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMS
HPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFS
KAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLE
KHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEE
GKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLR
KQEEHVTEPAPLVFDFDGHE
|
| External Links |
|---|
| GenBank ID Protein
| 242246985 |
| UniProtKB/Swiss-Prot ID
| P53675 |
| UniProtKB/Swiss-Prot Entry Name
| CLH2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007098.3 |
| GeneCard ID
| CLTCL1 |
| GenAtlas ID
| CLTCL1 |
| HGNC ID
| HGNC:2093 |
| References |
|---|
| General References
| Not Available |