Identification
HMDB Protein ID CDBP02826
Secondary Accession Numbers Not Available
Name Calmegin
Description Not Available
Synonyms Not Available
Gene Name CLGN
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Probably plays an important role in spermatogenesis. Binds calcium ions
GO Classification
Component
endoplasmic reticulum
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
ion binding
cation binding
metal ion binding
binding
unfolded protein binding
protein binding
calcium ion binding
Process
metabolic process
macromolecule metabolic process
cellular protein metabolic process
protein folding
protein metabolic process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q28.3-q31.1
SNPs CLGN
Gene Sequence
>1833 bp
ATGCATTTCCAAGCCTTTTGGCTATGTTTGGGTCTTCTGTTCATCTCAATTAATGCAGAA
TTTATGGATGATGATGTTGAGACGGAAGACTTTGAAGAAAATTCAGAAGAAATTGATGTT
AATGAAAGTGAACTTTCCTCAGAGATTAAATATAAGACACCTCAACCTATAGGAGAAGTA
TATTTTGCAGAAACTTTTGATAGTGGAAGGTTGGCTGGATGGGTCTTATCAAAAGCAAAG
AAAGATGACATGGATGAGGAAATTTCAATATACGATGGAAGATGGGAAATTGAAGAGTTG
AAAGAAAACCAGGTACCTGGTGACAGAGGACTGGTATTAAAATCTAGAGCAAAGCATCAT
GCAATATCTGCTGTATTAGCAAAACCATTCATTTTTGCTGATAAACCCTTGATAGTTCAA
TATGAAGTAAATTTTCAAGATGGTATTGATTGTGGAGGTGCATACATTAAACTCCTAGCA
GACACCGATGATTTGATTCTGGAAAACTTTTATGATAAAACATCCTATATCATTATGTTT
GGACCAGATAAATGTGGAGAAGATTATAAACTTCATTTTATCTTCAGACATAAACATCCC
AAAACTGGAGTTTTCGAAGAGAAACATGCCAAACCTCCAGATGTAGACCTTAAAAAGTTC
TTTACAGACAGGAAGACTCATCTTTATACCCTTGTGATGAATCCAGATGACACATTTGAG
GTGTTAGTTGATCAAACAGTTGTAAACAAAGGAAGCCTCCTAGAGGATGTGGTTCCTCCT
ATCAAACCTCCCAAAGAAATTGAAGATCCCAATGATAAAAAACCTGAGGAATGGGATGAA
AGAGCAAAAATTCCTGATCCTTCTGCCGTCAAACCAGAAGACTGGGATGAAAGTGAACCT
GCCCAAATAGAAGATTCAAGTGTTGTTAAACCTGCTGGCTGGCTTGATGATGAACCAAAA
TTTATCCCTGATCCTAATGCTGAAAAACCTGATGACTGGAATGAAGACACGGATGGAGAA
TGGGAGGCACCTCAGATTCTTAATCCAGCATGTCGGATTGGGTGTGGTGAGTGGAAACCT
CCCATGATAGATAACCCAAAATACAAAGGAGTATGGAGACCTCCACTGGTCGATAATCCT
AACTATCAGGGAATCTGGAGTCCTCGAAAAATTCCTAATCCAGATTATTTCGAAGATGAT
CATCCATTTCTTCTGACTTCTTTCAGTGCTCTTGGTTTAGAGCTTTGGTCTATGACCTCT
GATATCTACTTTGATAATTTTATTATCTGTTCGGAAAAGGAAGTAGCAGATCACTGGGCT
GCAGATGGTTGGAGATGGAAAATAATGATAGCAAATGCTAATAAGCCTGGTGTATTAAAA
CAGTTAATGGCAGCTGCTGAAGGGCACCCATGGCTTTGGTTGATTTATCTTGTGACAGCA
GGAGTGCCAATAGCATTAATTACTTCATTTTGTTGGCCAAGAAAAGTAAAGAAAAAACAT
AAAGATACAGAGTATAAAAAAACCGACATATGTATACCACAAACAAAAGGAGTACTAGAG
CAAGAAGAAAAGGAAGAGAAAGCAGCCCTGGAAAAACCAATGGACCTGGAAGAGGAAAAA
AAGCAAAATGATGGTGAAATGCTTGAAAAAGAAGAGGAAAGTGAACCTGAGGAAAAGAGT
GAAGAAGAAATTGAAATCATAGAAGGGCAAGAAGAAAGTAATCAATCAAATAAGTCTGGG
TCAGAGGATGAGATGAAAGAAGCAGATGAGAGCACAGGATCTGGAGATGGGCCGATAAAG
TCAGTACGCAAAAGAAGAGTACGAAAGGACTAA
Protein Properties
Number of Residues 610
Molecular Weight 70038.0
Theoretical pI 4.3
Pfam Domain Function
Signals
  • ["1-19"]
Transmembrane Regions
  • ["472-492"]
Protein Sequence
>Calmegin
MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEV
YFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHH
AISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMF
GPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFE
VLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEP
AQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACRIGCGEWKP
PMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTS
DIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTA
GVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEK
KQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIK
SVRKRRVRKD
GenBank ID Protein 193787446
UniProtKB/Swiss-Prot ID O14967
UniProtKB/Swiss-Prot Entry Name CLGN_HUMAN
PDB IDs Not Available
GenBank Gene ID AK093096
GeneCard ID CLGN
GenAtlas ID CLGN
HGNC ID HGNC:2060
References
General References Not Available