| Identification |
|---|
| HMDB Protein ID
| CDBP02816 |
| Secondary Accession Numbers
| Not Available |
| Name
| Claudin-18 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| CLDN18 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in structural molecule activity |
| Specific Function
| Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity |
| GO Classification
|
| Component |
| cell-cell junction |
| occluding junction |
| tight junction |
| membrane |
| cell part |
| membrane part |
| plasma membrane part |
| cell junction |
| Function |
| structural molecule activity |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- tight junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q22.3 |
| SNPs
| CLDN18 |
| Gene Sequence
|
>786 bp
ATGTCCACCACCACATGCCAAGTGGTGGCGTTCCTCCTGTCCATCCTGGGGCTGGCCGGC
TGCATCGCGGCCACCGGGATGGACATGTGGAGCACCCAGGACCTGTACGACAACCCCGTC
ACCTCCGTGTTCCAGTACGAAGGGCTCTGGAGGAGCTGCGTGAGGCAGAGTTCAGGCTTC
ACCGAATGCAGGCCCTATTTCACCATCCTGGGACTTCCAGCCATGCTGCAGGCAGTGCGA
GCCCTGATGATCGTAGGCATCGTCCTGGGTGCCATTGGCCTCCTGGTATCCATCTTTGCC
CTGAAATGCATCCGCATTGGCAGCATGGAGGACTCTGCCAAAGCCAACATGACACTGACC
TCCGGGATCATGTTCATTGTCTCAGGTCTTTGTGCAATTGCTGGAGTGTCTGTGTTTGCC
AACATGCTGGTGACTAACTTCTGGATGTCCACAGCTAACATGTACACCGGCATGGGTGGG
ATGGTGCAGACTGTTCAGACCAGGTACACATTTGGTGCGGCTCTGTTCGTGGGCTGGGTC
GCTGGAGGCCTCACACTAATTGGGGGTGTGATGATGTGCATCGCCTGCCGGGGCCTGGCA
CCAGAAGAAACCAACTACAAAGCCGTTTCTTATCATGCCTCAGGCCACAGTGTTGCCTAC
AAGCCTGGAGGCTTCAAGGCCAGCACTGGCTTTGGGTCCAACACCAAAAACAAGAAGATA
TACGATGGAGGTGCCCGCACAGAGGACGAGGTACAATCTTATCCTTCCAAGCACGACTAT
GTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 27856.3 |
| Theoretical pI
| 8.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["7-27", "81-101", "123-143", "175-195"]
|
| Protein Sequence
|
>Claudin-18
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF
TECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT
SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV
AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI
YDGGARTEDEVQSYPSKHDYV
|
| External Links |
|---|
| GenBank ID Protein
| 6715518 |
| UniProtKB/Swiss-Prot ID
| P56856 |
| UniProtKB/Swiss-Prot Entry Name
| CLD18_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF221069 |
| GeneCard ID
| CLDN18 |
| GenAtlas ID
| CLDN18 |
| HGNC ID
| HGNC:2039 |
| References |
|---|
| General References
| Not Available |