| Identification |
|---|
| HMDB Protein ID
| CDBP02814 |
| Secondary Accession Numbers
| Not Available |
| Name
| Claudin-16 |
| Description
| Not Available |
| Synonyms
|
- PCLN-1
- Paracellin-1
|
| Gene Name
| CLDN16 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in structural molecule activity |
| Specific Function
| Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors |
| GO Classification
|
| Component |
| cell-cell junction |
| occluding junction |
| tight junction |
| membrane |
| cell part |
| membrane part |
| plasma membrane part |
| cell junction |
| Function |
| structural molecule activity |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- tight junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q28 |
| SNPs
| CLDN16 |
| Gene Sequence
|
>918 bp
ATGACCTCCAGGACCCCACTGTTGGTTACAGCCTGTTTGTATTATTCTTACTGCAACTCA
AGACACCTGCAGCAGGGCGTGAGAAAAAGTAAAAGACCAGTATTTTCACATTGCCAGGTA
CCAGAAACACAGAAGACTGACACCCGCCACTTAAGTGGGGCCAGGGCTGGTGTCTGCCCA
TGTTGCCATCCTGATGGGCTGCTTGCCACAATGAGGGATCTTCTTCAATACATCGCTTGC
TTCTTTGCCTTTTTCTCTGCTGGGTTTTTGATTGTGGCCACCTGGACTGACTGTTGGATG
GTGAATGCTGATGACTCTCTGGAGGTGAGCACAAAATGCCGAGGCCTCTGGTGGGAATGC
GTCACAAATGCTTTTGATGGGATTCGCACCTGTGATGAGTACGATTCCATACTTGCGGAG
CATCCCTTGAAGCTGGTGGTAACTCGAGCGTTGATGATTACTGCAGATATTCTAGCTGGG
TTTGGATTTCTCACCCTGCTCCTTGGTCTTGACTGCGTGAAATTCCTCCCTGATGAGCCG
TACATTAAAGTCCGCATCTGCTTTGTTGCTGGAGCCACGTTACTAATAGCAGGTACCCCA
GGAATCATTGGCTCTGTGTGGTATGCTGTTGATGTGTATGTGGAACGTTCTACTTTGGTT
TTGCACAATATATTTCTTGGTATCCAATATAAATTTGGTTGGTCCTGTTGGCTCGGAATG
GCTGGGTCTCTGGGTTGCTTTTTGGCTGGAGCTGTTCTCACCTGCTGCTTATATCTTTTT
AAAGATGTTGGACCTGAGAGAAACTATCCTTATTCCTTGAGGAAAGCCTATTCAGCCGCG
GGTGTTTCCATGGCCAAGTCATACTCAGCCCCTCGCACAGAGACGGCCAAAATGTATGCT
GTAGACACAAGGGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 305 |
| Molecular Weight
| 33836.1 |
| Theoretical pI
| 7.97 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["74-94", "151-171", "186-206", "240-260"]
|
| Protein Sequence
|
>Claudin-16
MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP
CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC
VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP
YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM
AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA
VDTRV
|
| External Links |
|---|
| GenBank ID Protein
| 5410527 |
| UniProtKB/Swiss-Prot ID
| Q9Y5I7 |
| UniProtKB/Swiss-Prot Entry Name
| CLD16_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF152101 |
| GeneCard ID
| CLDN16 |
| GenAtlas ID
| CLDN16 |
| HGNC ID
| HGNC:2037 |
| References |
|---|
| General References
| Not Available |