Showing Protein C-type lectin domain family 4 member C (CDBP02804)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02804
Secondary Accession Numbers Not Available
Name C-type lectin domain family 4 member C
Description Not Available
Synonyms
  1. BDCA-2
  2. Blood dendritic cell antigen 2
  3. C-type lectin superfamily member 7
  4. CD303 antigen
  5. Dendritic lectin
Gene Name CLEC4C
Protein Type Enzyme
Biological Properties
General Function Involved in sugar binding
Specific Function Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose
GO Classification
Function
binding
carbohydrate binding
sugar binding
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13.2-p12.3
SNPs CLEC4C
Gene Sequence 
>642 bp
ATGGTGCCTGAAGAAGAGCCTCAAGACCGAGAGAAAGGACTCTGGTGGTTCCAGTTGAAG
GTCTGGTCCATGGCAGTCGTATCCATCTTGCTCCTCAGTGTCTGTTTCACTGTGAGTTCT
GTGGTGCCTCACAATTTTATGTATAGCAAAACTGTCAAGAGGCTGTCCAAGTTACGAGAG
TATCAACAGTATCATCCAAGCCTGACCTGCGTCATGGAAGGAAAGGACATAGAAGATTGG
AGCTGCTGCCCAACCCCTTGGACTTCATTTCAGTCTAGTTGCTACTTTATTTCTACTGGG
ATGCAATCTTGGACTAAGAGTCAAAAGAACTGTTCTGTGATGGGGGCTGATCTGGTGGTG
ATCAACACCAGGGAAGAACAGGATTTCATCATTCAGAATCTGAAAAGAAATTCTTCTTAT
TTTCTGGGGCTGTCAGATCCAGGGGGTCGGCGACATTGGCAATGGGTTGACCAGACACCA
TACAATGAAAATGTCACATTCTGGCACTCAGGTGAACCCAATAACCTTGATGAGCGTTGT
GCGATAATAAATTTCCGTTCTTCAGAAGAATGGGGCTGGAATGACATTCACTGTCATGTA
CCTCAGAAGTCAATTTGCAAGATGAAGAAGATCTACATATAA
Protein Properties
Number of Residues 213
Molecular Weight 25037.4
Theoretical pI 7.05
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["22-44"]
Protein Sequence 
>C-type lectin domain family 4 member C
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLRE
YQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVV
INTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERC
AIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI
GenBank ID Protein 17224598
UniProtKB/Swiss-Prot ID Q8WTT0
UniProtKB/Swiss-Prot Entry Name CLC4C_HUMAN
PDB IDs Not Available
GenBank Gene ID AF293615
GeneCard ID CLEC4C
GenAtlas ID CLEC4C
HGNC ID HGNC:13258
References
General References Not Available