Showing Protein CDGSH iron-sulfur domain-containing protein 2 (CDBP02801)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP02801
Secondary Accession Numbers Not Available
Name CDGSH iron-sulfur domain-containing protein 2
Description Not Available
Synonyms
  1. Endoplasmic reticulum intermembrane small protein
  2. Miner1
  3. MitoNEET-related 1 protein
  4. NAF-1
  5. Nutrient-deprivation autophagy factor-1
Gene Name CISD2
Protein Type Enzyme
Biological Properties
General Function Involved in 2 iron, 2 sulfur cluster binding
Specific Function Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates to the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
binding
metal cluster binding
iron-sulfur cluster binding
2 iron, 2 sulfur cluster binding
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Single-pass membrane protein
  3. Single-pass membrane protein
  4. Mitochondrion outer membrane
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q24
SNPs CISD2
Gene Sequence 
>408 bp
ATGGTGCTGGAGAGCGTGGCCCGTATCGTGAAGGTGCAGCTCCCTGCATATCTGAAGCGG
CTCCCAGTCCCTGAAAGCATTACCGGGTTCGCTAGGCTCACAGTTTCAGAATGGCTTCGG
TTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCTTGCAGTTCGTCCATTCCTC
CCGAAGAAGAAACAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCG
AAAGTAGTGAATGAAATAAACATTGAAGATTTGTGTCTTACTAAAGCAGCTTATTGTAGG
TGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACATAATAAACACAATGAATTG
ACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTATAA
Protein Properties
Number of Residues 135
Molecular Weight 15278.0
Theoretical pI 10.25
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["38-60"]
Protein Sequence 
>CDGSH iron-sulfur domain-containing protein 2
MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFL
PKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNEL
TGDNVGPLILKKKEV
GenBank ID Protein 158257700
UniProtKB/Swiss-Prot ID Q8N5K1
UniProtKB/Swiss-Prot Entry Name CISD2_HUMAN
PDB IDs Not Available
GenBank Gene ID AK292134
GeneCard ID CISD2
GenAtlas ID CISD2
HGNC ID HGNC:24212
References
General References Not Available