| Identification |
|---|
| HMDB Protein ID
| CDBP02794 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-C chemokine receptor type 6 |
| Description
| Not Available |
| Synonyms
|
- C-C CKR-6
- CC-CKR-6
- CCR-6
- CD196 antigen
- CKR-L3
- Chemokine receptor-like 3
- DRY6
- G-protein coupled receptor 29
- GPR-CY4
- GPRCY4
- LARC receptor
|
| Gene Name
| CCR6 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| receptor activity |
| g-protein chemoattractant receptor activity |
| chemokine receptor activity |
| c-c chemokine receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q27 |
| SNPs
| CCR6 |
| Gene Sequence
|
>1125 bp
ATGAGCGGGGAATCAATGAATTTCAGCGATGTTTTCGACTCCAGTGAAGATTATTTTGTG
TCAGTCAATACTTCATATTACTCAGTTGATTCTGAGATGTTACTGTGCTCCTTGCAGGAG
GTCAGGCAGTTCTCCAGGCTATTTGTACCGATTGCCTACTCCTTGATCTGTGTCTTTGGC
CTCCTGGGGAATATTCTGGTGGTGATCACCTTTGCTTTTTATAAGAAGGCCAGGTCTATG
ACAGACGTCTATCTCTTGAACATGGCCATTGCAGACATCCTCTTTGTTCTTACTCTCCCA
TTCTGGGCAGTGAGTCATGCCACCGGTGCGTGGGTTTTCAGCAATGCCACGTGCAAGTTG
CTAAAAGGCATCTATGCCATCAACTTTAACTGCGGGATGCTGCTCCTGACTTGCATTAGC
ATGGACCGGTACATCGCCATTGTACAGGCGACTAAGTCATTCCGGCTCCGATCCAGAACA
CTACCGCGCAGCAAAATCATCTGCCTTGTTGTGTGGGGGCTGTCAGTCATCATCTCCAGC
TCAACTTTTGTCTTCAACCAAAAATACAACACCCAAGGCAGCGATGTCTGTGAACCCAAG
TACCAGACTGTCTCGGAGCCCATCAGGTGGAAGCTGCTGATGTTGGGGCTTGAGCTACTC
TTTGGTTTCTTTATCCCTTTGATGTTCATGATATTTTGTTACACGTTCATTGTCAAAACC
TTGGTGCAAGCTCAGAATTCTAAAAGGCACAAAGCCATCCGTGTAATCATAGCTGTGGTG
CTTGTGTTTCTGGCTTGTCAGATTCCTCATAACATGGTCCTGCTTGTGACGGCTGCAAAT
TTGGGTAAAATGAACCGATCCTGCCAGAGCGAAAAGCTAATTGGCTATACGAAAACTGTC
ACAGAAGTCCTGGCTTTCCTGCACTGCTGCCTGAACCCTGTGCTCTACGCTTTTATTGGG
CAGAAGTTCAGAAACTACTTTCTGAAGATCTTGAAGGACCTGTGGTGTGTGAGAAGGAAG
TACAAGTCCTCAGGCTTCTCCTGTGCCGGGAGGTACTCAGAAAACATTTCTCGGCAGACC
AGTGAGACCGCAGATAACGACAATGCGTCGTCCTTCACTATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 374 |
| Molecular Weight
| 42493.7 |
| Theoretical pI
| 9.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["48-74", "84-104", "120-141", "160-180", "212-238", "255-279", "304-321"]
|
| Protein Sequence
|
>C-C chemokine receptor type 6
MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFG
LLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKL
LKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISS
STFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKT
LVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTV
TEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQT
SETADNDNASSFTM
|
| External Links |
|---|
| GenBank ID Protein
| 9453791 |
| UniProtKB/Swiss-Prot ID
| P51684 |
| UniProtKB/Swiss-Prot Entry Name
| CCR6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL121935 |
| GeneCard ID
| CCR6 |
| GenAtlas ID
| CCR6 |
| HGNC ID
| HGNC:1607 |
| References |
|---|
| General References
| Not Available |