| Identification |
|---|
| HMDB Protein ID
| CDBP02792 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-C chemokine receptor type 4 |
| Description
| Not Available |
| Synonyms
|
- C-C CKR-4
- CC-CKR-4
- CCR-4
- CCR4
- CD194 antigen
- K5-5
|
| Gene Name
| CCR4 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| peptide receptor activity, g-protein coupled |
| receptor activity |
| g-protein chemoattractant receptor activity |
| chemokine receptor activity |
| c-c chemokine receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p24 |
| SNPs
| CCR4 |
| Gene Sequence
|
>1083 bp
ATGAACCCCACGGATATAGCAGATACCACCCTCGATGAAAGCATATACAGCAATTACTAT
CTGTATGAAAGTATCCCCAAGCCTTGCACCAAAGAAGGCATCAAGGCATTTGGGGAGCTC
TTCCTGCCCCCACTGTATTCCTTGGTTTTTGTATTTGGTCTGCTTGGAAATTCTGTGGTG
GTTCTGGTCCTGTTCAAATACAAGCGGCTCAGGTCCATGACTGATGTGTACCTGCTCAAC
CTTGCCATCTCGGATCTGCTCTTCGTGTTTTCCCTCCCTTTTTGGGGCTACTATGCAGCA
GACCAGTGGGTTTTTGGGCTAGGTCTGTGCAAGATGATTTCCTGGATGTACTTGGTGGGC
TTTTACAGTGGCATATTCTTTGTCATGCTCATGAGCATTGATAGATACCTGGCAATTGTG
CACGCGGTGTTTTCCTTGAGGGCAAGGACCTTGACTTATGGGGTCATCACCAGTTTGGCT
ACATGGTCAGTGGCTGTGTTCGCCTCCCTTCCTGGCTTTCTGTTCAGCACTTGTTATACT
GAGCGCAACCATACCTACTGCAAAACCAAGTACTCTCTCAACTCCACGACGTGGAAGGTT
CTCAGCTCCCTGGAAATCAACATTCTCGGATTGGTGATCCCCTTAGGGATCATGCTGTTT
TGCTACTCCATGATCATCAGGACCTTGCAGCATTGTAAAAATGAGAAGAAGAACAAGGCG
GTGAAGATGATCTTTGCCGTGGTGGTCCTCTTCCTTGGGTTCTGGACACCTTACAACATA
GTGCTCTTCCTAGAGACCCTGGTGGAGCTAGAAGTCCTTCAGGACTGCACCTTTGAAAGA
TACTTGGACTATGCCATCCAGGCCACAGAAACTCTGGCTTTTGTTCACTGCTGCCTTAAT
CCCATCATCTACTTTTTTCTGGGGGAGAAATTTCGCAAGTACATCCTACAGCTCTTCAAA
ACCTGCAGGGGCCTTTTTGTGCTCTGCCAATACTGTGGGCTCCTCCAAATTTACTCTGCT
GACACCCCCAGCTCATCTTACACGCAGTCCACCATGGATCATGATCTCCATGATGCTCTG
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 360 |
| Molecular Weight
| 41402.4 |
| Theoretical pI
| 7.58 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["40-67", "78-98", "112-133", "151-175", "207-226", "243-267", "285-308"]
|
| Protein Sequence
|
>C-C chemokine receptor type 4
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
|
| External Links |
|---|
| GenBank ID Protein
| 6467135 |
| UniProtKB/Swiss-Prot ID
| P51679 |
| UniProtKB/Swiss-Prot Entry Name
| CCR4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB023888 |
| GeneCard ID
| CCR4 |
| GenAtlas ID
| CCR4 |
| HGNC ID
| HGNC:1605 |
| References |
|---|
| General References
| Not Available |