| Identification |
|---|
| HMDB Protein ID
| CDBP02768 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-dependent secretion activator 1 |
| Description
| Not Available |
| Synonyms
|
- CAPS-1
- Calcium-dependent activator protein for secretion 1
|
| Gene Name
| CADPS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Peripheral membrane protein
- Cytoplasmic side
- Cell junction
- synapse
- Cytoplasmic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p14.2 |
| SNPs
| CADPS |
| Gene Sequence
|
>4062 bp
ATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCGGC
AAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGTCTCCCAGCCGTACCAGCGAG
GGCTCGGCCGGCAGCGCCGGGCTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGT
GCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAACCC
AGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCCCGTCGGTGGTGAGCGAGAAG
GAGAAGGAAGAGTTGGAGCGGCTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAG
CTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCGAC
ATGGCTCGCCGGCAGCAGAAGATCAGCAAACAGCAGCTGCAGACAGTCAAGGACCGGTTT
CAGGCTTTCCTCAATGGGGAAACCCAGATCATGGCTGACGAAGCCTTCATGAACGCTGTG
CAGAGTTACTATGAGGTGTTCCTGAAGAGCGACCGTGTGGCCCGCATGGTTCAGAGTGGA
GGCTGTTCCGCCAACGACTCCCGGGAGGTCTTCAAGAAGCACATTGAGAAGAGAGTGCGC
AGCCTGCCTGAGATTGACGGCCTCAGCAAGGAGACTGTGCTGAGCTCCTGGATGGCCAAA
TTTGATGCCATCTACCGTGGAGAAGAGGACCCGCGGAAGCAGCAGGCCCGGATGACAGCC
AGCGCAGCCTCCGAGCTGATTCTGAGCAAGGAGCAACTCTATGAGATGTTCCAGAACATT
CTTGGGATCAAGAAGTTCGAACATCAGCTCCTTTACAATGCCTGCCAGCTGGACAATCCA
GATGAGCAAGCAGCCCAGATCAGACGAGAGCTGGATGGACGTCTACAAATGGCAGACCAA
ATAGCCAGGGAACGCAAATTTCCCAAGTTTGTATCCAAAGAAATGGAAAACATGTACATT
GAGGAGCTGAAGTCATCTGTCAACCTGCTCATGGCCAACTTGGAGAGCATGCCGGTATCC
AAAGGCGGGGAGTTCAAGCTCCAGAAACTCAAACGCAGCCACAATGCTTCCATCATCGAC
ATGGGCGAGGAGAGTGAGAACCAGCTCTCCAAGTCAGATGTCGTGCTGTCTTTCTCATTG
GAGGTGGTAATTATGGAAGTCCAAGGCCTCAAATCTTTGGCTCCAAATCGCATCGTATAT
TGCACAATGGAGGTGGAAGGAGGAGAGAAACTACAGACTGATCAGGCCGAGGCTTCTAAA
CCAACCTGGGGCACCCAGGGTGACTTCTCCACAACCCATGCACTGCCAGCTGTGAAGGTG
AAGCTGTTCACAGAGAGCACAGGCGTCCTGGCGTTGGAGGACAAGGAGCTTGGGCGGGTT
ATTCTCCATCCCACCCCGAACAGCCCCAAACAGTCAGAGTGGCACAAAATGACAGTCTCC
AAAAACTGCCCCGACCAAGATCTCAAAATCAAACTTGCTGTCCGAATGGATAAGCCTCAA
AACATGAAGCATTCTGGGTATTTATGGGCCATCGGTAAGAATGTCTGGAAGAGATGGAAG
AAAAGGTTTTTTGTATTGGTGCAGGTCAGTCAGTACACGTTTGCCATGTGCAGTTATCGG
GAGAAGAAAGCGGAGCCTCAGGAACTTCTACAATTGGATGGCTACACTGTGGATTACACC
GACCCCCAGCCAGGTTTGGAGGGTGGCCGAGCCTTCTTCAATGCTGTCAAGGAGGGAGAC
ACCGTGATATTTGCCAGTGACGATGAACAAGACCGCATCCTGTGGGTCCAGGCCATGTAT
CGGGCCACGGGGCAGTCACACAAGCCTGTGCCCCCGACCCAAGTCCAGAAACTCAACGCC
AAGGGAGGAAATGTACCTCAGCTGGATGCCCCTATCTCTCAATTTTACGCAGATAGAGCT
CAAAAACATGGCATGGATGAATTTATCTCTTCCAACCCCTGTAACTTTGACCACGCTTCC
CTCTTTGAGATGGTACAACGCCTTACTTTGGATCACAGACTTAATGATTCCTATTCTTGC
CTGGGCTGGTTCAGTCCTGGCCAGGTGTTTGTACTAGACGAGTATTGCGCCCGAAATGGA
GTCCGGGGGTGTCACCGACATCTCTGCTACCTCAGAGACTTGCTTGAACGGGCAGAAAAT
GGCGCCATGATCGACCCCACCCTTCTTCACTACAGCTTTGCCTTCTGTGCATCCCATGTC
CATGGGAACAGGCCTGATGGAATTGGAACTGTGACTGTTGAAGAAAAGGAACGTTTTGAA
GAAATCAAAGAGAGGCTCCGAGTTCTGCTAGAAAATCAGATTACACATTTTAGGTATTGC
TTTCCATTTGGTCGACCTGAAGGTGCTTTGAAAGCTACTCTCTCACTCTTGGAAAGGGTT
TTGATGAAAGATATTGTTACCCCAGTGCCACAAGAGGAGGTAAAAACAGTTATCCGTAAA
TGTCTGGAACAGGCTGCGTTAGTCAACTATTCTCGGCTCTCAGAGTATGCCAAAATCGAA
GAGAATCAAAAGGATGCAGAAAATGTAGGCCGGTTAATCACTCCTGCCAAAAAGCTTGAA
GATACAATACGTCTTGCTGAACTAGTCATTGAAGTTCTTCAGCAAAATGAGGAGCACCAC
GCAGAGCCACATGTTGATAAAGGAGAAGCCTTTGCGTGGTGGTCAGATTTAATGGTGGAG
CATGCGGAGACGTTCCTGTCACTCTTTGCAGTAGACATGGATGCAGCCTTAGAGGTGCAA
CCTCCAGACACATGGGACAGTTTTCCACTATTTCAGCTGCTGAATGATTTTCTCCGTACT
GACTATAATTTGTGCAATGGAAAATTTCACAAACACCTGCAAGACCTGTTTGCCCCACTT
GTTGTTAGATATGTGGATCTGATGGAGTCCTCAATTGCACAATCCATTCACAGGGGCTTT
GAGCGGGAGTCATGGGAACCAGTCAAGAGTTTAACCAGTAACCTACCCAATGTGAACCTA
CCCAATGTGAACCTTCCCAAAGTACCAAATCTACCAGTTAACATCCCTCTAGGCATCCCA
CAAATGCCTACTTTTTCGGCACCGTCATGGATGGCTGCTATATATGATGCGGATAATGGG
TCAGGCACCTCAGAAGATCTGTTTTGGAAACTTGACGCCCTTCAGACCTTCATTCGGGAC
CTGCACTGGCCTGAAGAAGAGTTTGGAAAGCACCTGGAACAACGGCTGAAGTTGATGGCA
AGTGACATGATCGAATCTTGTGTCAAAAGAACCAGGATTGCATTTGAAGTTAAGCTGCAA
AAAACCAGTCGATCAACAGATTTTCGAGTCCCACAGTCAATATGCACCATGTTTAATGTT
ATGGTTGATGCCAAAGCTCAATCAACAAAACTTTGCAGCATGGAAATGGGCCAAGAGCAT
CAATACCATTCAAAAATAGACGAACTAATTGAAGAAACTGTTAAAGAAATGATAACACTC
TTGGTTGCAAAGTTCGTTACTATCTTGGAAGGAGTGCTGGCAAAATTATCCAGATATGAC
GAAGGGACTTTGTTTTCTTCTTTTCTGTCATTTACCGTGAAGGCAGCTTCCAAATATGTG
GATGTACCTAAACCCGGGATGGACGTGGCCGACGCCTACGTGACTTTCGTCCGCCATTCT
CAGGATGTCCTGCGTGATAAGGTCAATGAGGAGATGTACATAGAAAGGTTATTTGATCAA
TGGTACAACAGCTCCATGAACGTGATCTGCACCTGGTTGACGGACCGGATGGACTTACAG
CTTCATATTTATCAGTTGAAAACACTAATTAGGATGGTAAAGAAAACCTACAGAGATTTC
CGATTGCAAGGGGTCCTGGACTCCACCTTAAACAGCAAGACCTATGAAACGATCCGGAAC
CGTCTCACTGTGGAGGAAGCCACAGCATCAGTGAGTGAAGGTGGGGGACTGCAGGGCATC
AGCATGAAGGACAGCGATGAGGAAGACGAAGAAGACGATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1353 |
| Molecular Weight
| 152785.4 |
| Theoretical pI
| 5.44 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-dependent secretion activator 1
MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVG
AGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQ
LYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIMADEAFMNAV
QSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAK
FDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNP
DEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVS
KGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVY
CTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRV
ILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWK
KRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGD
TVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRA
QKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNG
VRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFE
EIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRK
CLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHH
AEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRT
DYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNL
PNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRD
LHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNV
MVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYD
EGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQ
WYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRN
RLTVEEATASVSEGGGLQGISMKDSDEEDEEDD
|
| External Links |
|---|
| GenBank ID Protein
| 34452715 |
| UniProtKB/Swiss-Prot ID
| Q9ULU8 |
| UniProtKB/Swiss-Prot Entry Name
| CAPS1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_003716.3 |
| GeneCard ID
| CADPS |
| GenAtlas ID
| CADPS |
| HGNC ID
| HGNC:1426 |
| References |
|---|
| General References
| Not Available |