| Identification |
|---|
| HMDB Protein ID
| CDBP02757 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calpain-13 |
| Description
| Not Available |
| Synonyms
|
- CANP 13
- Calcium-activated neutral proteinase 13
|
| Gene Name
| CAPN13 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium-dependent cysteine-type endopeptidase activity |
| Specific Function
| Probable non-lysosomal thiol-protease |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| endopeptidase activity |
| cysteine-type endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium-dependent cysteine-type endopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| calcium ion binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p22-p21 |
| SNPs
| CAPN13 |
| Gene Sequence
|
>2010 bp
ATGGCGTATTACCAGGAGCCTTCAGTGGAGACCTCCATCATCAAGTTCAAAGACCAGGAC
TTTACCACCTTGCGGGATCACTGCCTGAGCATGGGCCGGACGTTTAAGGATGAGACATTC
CCTGCAGCAGATTCTTCCATAGGCCAGAAGCTGCTCCAGGAAAAACGCCTCTCCAATGTG
ATATGGAAGCGGCCACAGGATCTACCAGGGGGTCCTCCTCACTTCATCCTGGATGATATA
AGCAGATTTGACATCCAACAAGGAGGCGCAGCTGACTGCTGGTTCCTGGCAGCACTGGGA
TCCTTGACTCAGAACCCACAGTACAGGCAGAAGATCCTGATGGTCCAAAGCTTTTCACAC
CAGTATGCTGGCATTTTCCGTTTCCGGTTCTGGCAATGTGGCCAGTGGGTGGAAGTGGTG
ATTGATGACCGCCTACCTGTCCAGGGAGATAAATGCCTCTTTGTGCGTCCTCGCCACCAA
AACCAAGAGTTCTGGCCCTGCCTGCTGGAGAAGGCCTATGCCAAGCTGCTCGGATCCTAT
TCCGATCTGCACTATGGCTTCCTCGAGGATGCCCTGGTGGACCTCACAGGAGGCGTGATC
ACCAACATCCATCTGCACTCTTCCCCTGTGGACCTGGTGAAGGCAGTGAAGACAGCGACC
AAGGCAGGCTCCCTGATAACCTGTGCCACTCCAAGTGGGCCAACAGATACAGCACAGGCG
ATGGAGAATGGGCTGGTGAGTCTCCATGCCTACACTGTGACTGGGGCTGAGCAGATTCAA
TACCGAAGGGGCTGGGAAGAAATTATCTCCCTGTGGAACCCCTGGGGCTGGGGCGAGGCC
GAATGGAGAGGGCGCTGGAGTGATGGGTCTCAGGAGTGGGAGGAAACCTGTGATCCGCGG
AAAAGCCAGCTACATAAGAAACGGGAAGATGGCGAGTTTTGGATGTCGTGTCAAGATTTC
CAACAGAAATTCATCGCCATGTTTATATGTAGCGAAATTCCAATTACCCTGGACCATGGA
AACACACTCCACGAAGGATGGTCCCAAATAATGTTTAGGAAGCAAGTGATTCTAGGAAAC
ACTGCAGGAGGACCTCGGAATGATGCTCAATTCAACTTCTCTGTGCAAGAGCCAATGGAA
GGCACCAATGTTGTCGTGTGCGTCACAGTTGCTGTCACACCATCAAATTTGAAAGCAGAA
GATGCAAAATTTCCACTCGATTTCCAAGTGATTCTGGCTGGCTCACAGCGGTTCCGGGAG
AAATTTCCACCCGTGTTTTTTTCCTCGTTCAGAAACACTGTCCAAAGCTCAAATAATAAA
TTCCGCCGCAACTTCACCATGACTTACCATCTGAGCCCTGGGAACTATGTTGTGGTTGCA
CAGACACGGAGAAAATCAGCGGAGTTCTTGCTCCGAATCTTCCTGAAAATGCCAGACAGT
GACAGGCACCTGAGCAGCCATTTCAACCTCAGAATGAAGGGAAGCCCTTCAGAACATGGC
TCCCAACAAAGCATTTTCAACAGATATGCTCAGCAGAGGCTGGACATTGATGCCACCCAG
CTTCAGGGCCTTCTCAACCAGGAGCTTCTAACAGGACCTCCAGGGGACATGTTCTCCTTA
GATGAGTGCCGCAGCTTGGTGGCTCTGATGGAACTGAAAGTGAATGGGCGGCTAGACCAA
GAGGAGTTTGCGCGACTGTGGAAGCGCCTTGTTCACTACCAGCATGTTTTCCAGAAGGTT
CAGACAAGCCCTGGAGTCCTCCTGAGCTCGGACTTGTGGAAGGCCATAGAGAATACAGAC
TTCCTCAGAGGGATCTTCATCAGCCGTGAGCTGCTGCATCTGGTGACCCTCAGGTACAGC
GACAGCGTCGGCAGGGTCAGCTTCCCCAGCCTGGTCTGCTTCCTGATGCGGCTTGAAGCC
ATGGCAAAGACCTTCCGCAACCTCTCTAAGGATGGAAAAGGACTCTACCTGACAGAAATG
GAGTGGATGAGCCTGGTCATGTACAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 669 |
| Molecular Weight
| 76695.9 |
| Theoretical pI
| 7.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calpain-13
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNV
IWKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSH
QYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQA
MENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPR
KSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGN
TAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE
KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDS
DRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSL
DECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTD
FLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEM
EWMSLVMYN
|
| External Links |
|---|
| GenBank ID Protein
| 41152101 |
| UniProtKB/Swiss-Prot ID
| Q6MZZ7 |
| UniProtKB/Swiss-Prot Entry Name
| CAN13_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_144575.2 |
| GeneCard ID
| CAPN13 |
| GenAtlas ID
| CAPN13 |
| HGNC ID
| HGNC:16663 |
| References |
|---|
| General References
| Not Available |