| Identification |
|---|
| HMDB Protein ID
| CDBP02747 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calreticulin-3 |
| Description
| Not Available |
| Synonyms
|
- Calreticulin-2
|
| Gene Name
| CALR3 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER |
| GO Classification
|
| Component |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| endoplasmic reticulum |
| organelle |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| unfolded protein binding |
| protein binding |
| calcium ion binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular protein metabolic process |
| protein folding |
| protein metabolic process |
|
| Cellular Location
|
- Endoplasmic reticulum lumen
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.11 |
| SNPs
| CALR3 |
| Gene Sequence
|
>1155 bp
ATGGCCCGGGCTTTGGTCCAGCTCTGGGCCATATGCATGCTGCGAGTGGCGCTGGCTACC
GTCTATTTCCAAGAGGAATTTCTAGACGGAGAGCATTGGAGAAACCGATGGTTGCAGTCC
ACCAATGACTCCCGATTTGGGCATTTTAGACTTTCGTCGGGCAAGTTTTATGGTCATAAA
GAGAAAGATAAAGGTCTGCAAACCACTCAGAATGGCCGATTCTATGCCATCTCTGCACGC
TTCAAACCGTTCAGCAATAAAGGGAAAACTCTGGTTATTCAGTACACAGTAAAACATGAG
CAGAAGATGGACTGTGGAGGGGGCTACATTAAGGTCTTTCCTGCAGACATTGACCAGAAG
AACCTGAATGGAAAATCGCAATACTATATTATGTTTGGACCCGATATTTGTGGATTTGAT
ATCAAGAAAGTTCATGTTATTTTACATTTCAAGAATAAGTATCACGAAAACAAGAAACTG
ATCAGGTGTAAGGTTGATGGCTTCACACACCTGTACACTCTAATTTTAAGACCAGATCTT
TCTTATGATGTGAAAATTGATGGTCAGTCAATTGAATCCGGCAGCATAGAGTACGACTGG
AACTTAACATCACTCAAGAAGGAAACGTCCCCGGCAGAATCGAAGGATTGGGAACAGACT
AAAGACAACAAAGCCCAGGACTGGGAGAAGCATTTTCTGGACGCCAGCACCAGCAAGCAG
AGCGACTGGAACGGTGACCTGGATGGGGACTGGCCAGCGCCGATGCTCCAGAAGCCCCCG
TACCAGGATGGCCTGAAACCAGAAGGTATTCATAAAGACGTCTGGCTCCACCGTAAGATG
AAGAATACCGACTATTTGACGCAGTATGACCTCTCAGAATTTGAGAACATTGGTGCCATT
GGCCTGGAGCTTTGGCAGGTGAGATCTGGAACCATTTTTGATAACTTTCTGATCACAGAT
GATGAAGAGTATGCAGATAATTTTGGCAAGGCCACCTGGGGCGAAACCAAGGGTCCAGAA
AGGGAGATGGATGCCATACAGGCCAAGGAGGAAATGAAGAAGGCCCGCGAGGAAGAGGAG
GAAGAGCTGCTGTCGGGAAAAATTAACAGGCACGAACATTACTTCAATCAATTTCACAGA
AGGAATGAACTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 384 |
| Molecular Weight
| 44995.3 |
| Theoretical pI
| 6.64 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calreticulin-3
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHK
EKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQK
NLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDL
SYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQ
SDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAI
GLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEE
EELLSGKINRHEHYFNQFHRRNEL
|
| External Links |
|---|
| GenBank ID Protein
| 16554107 |
| UniProtKB/Swiss-Prot ID
| Q96L12 |
| UniProtKB/Swiss-Prot Entry Name
| CALR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK058084 |
| GeneCard ID
| CALR3 |
| GenAtlas ID
| CALR3 |
| HGNC ID
| HGNC:20407 |
| References |
|---|
| General References
| Not Available |