Identification
HMDB Protein ID CDBP02739
Secondary Accession Numbers Not Available
Name Cadherin-8
Description Not Available
Synonyms Not Available
Gene Name CDH8
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16q22.1
SNPs CDH8
Gene Sequence
>2400 bp
ATGCCAGAACGGCTAGCGGAAATGCTCTTGGATCTCTGGACTCCATTAATAATATTATGG
ATTACTCTTCCCCCTTGCATTTACATGGCTCCGATGAATCAGTCTCAAGTTTTAATGAGT
GGATCCCCTTTGGAACTAAACAGTCTGGGTGAAGAACAGCGAATTTTGAACCGCTCCAAA
AGAGGCTGGGTTTGGAATCAAATGTTTGTCCTGGAAGAGTTTTCTGGACCTGAACCGATT
CTTGTTGGCCGGCTACACACAGACCTGGATCCTGGGAGCAAAAAAATCAAGTATATCCTA
TCAGGTGATGGAGCTGGGACCATATTTCAAATAAATGATGTAACTGGAGATATCCATGCT
ATAAAAAGACTTGACCGGGAGGAAAAGGCTGAGTATACCCTAACAGCTCAAGCAGTGGAC
TGGGAGACAAGCAAACCTCTGGAGCCTCCTTCTGAATTTATTATTAAAGTTCAAGACATC
AATGACAATGCACCAGAGTTTCTTAATGGACCCTATCATGCTACTGTGCCAGAAATGTCC
ATTTTGGGTACATCTGTCACTAACGTCACTGCGACCGACGCTGATGACCCAGTTTATGGA
AACAGTGCAAAGTTGGTTTATAGTATATTGGAAGGGCAGCCTTATTTTTCCATTGAGCCT
GAAACAGCTATTATAAAAACTGCCCTTCCCAACATGGACAGAGAAGCCAAGGAGGAGTAC
CTGGTTGTTATCCAAGCCAAAGATATGGGTGGACACTCTGGTGGCCTGTCTGGGACCACG
ACACTTACAGTGACTCTTACTGATGTTAATGACAATCCTCCAAAATTTGCACAGAGCCTG
TATCACTTCTCAGTACCGGAAGATGTGGTTCTTGGCACTGCAATAGGAAGGGTGAAGGCC
AATGATCAGGATATTGGTGAAAATGCACAGTCATCATATGATATCATCGATGGAGATGGA
ACAGCACTTTTTGAAATCACTTCTGATGCCCAGGCCCAGGATGGCATTATAAGGCTAAGA
AAACCTCTGGACTTTGAGACCAAAAAATCCTATACGCTAAAGGTAGAGGCAGCCAATGTC
CATATTGACCCACGCTTCAGTGGCAGGGGGCCCTTTAAAGACACGGCGACAGTCAAAATC
GTGGTTGAAGATGCTGATGAGCCTCCGGTCTTCTCTTCACCGACTTACCTACTTGAAGTT
CATGAAAATGCTGCTCTAAACTCCGTGATTGGGCAAGTGACTGCTCGTGACCCTGATATC
ACTTCCAGTCCTATAAGGTTTTCCATCGACCGGCACACTGACCTGGAGAGGCAGTTCAAC
ATTAATGCAGACGATGGGAAGATAACGCTGGCAACACCACTTGACAGAGAATTAAGTGTA
TGGCACAACATAACAATCATTGCTACTGAAATTAGGAACCACAGTCAGATATCACGAGTA
CCTGTTGCTATTAAAGTGCTGGATGTCAATGACAACGCCCCTGAATTCGCATCCGAATAT
GAGGCATTTTTATGTGAAAATGGAAAACCCGGCCAAGTCATTCAAACTGTTAGCGCCATG
GACAAAGATGATCCCAAAAACGGACATTATTTCTTATACAGTCTCCTTCCAGAAATGGTC
AACAATCCGAATTTCACCATCAAGAAAAATGAAGATAATTCCCTCAGTATTTTGGCAAAG
CATAATGGATTCAACCGCCAGAAGCAAGAAGTCTATCTTTTACCAATCATAATCAGTGAT
AGTGGAAATCCTCCACTGAGCAGCACTAGCACCTTGACAATCAGGGTCTGTGGCTGCAGC
AATGACGGTGTCGTCCAGTCTTGCAATGTCGAAGCTTATGTCCTTCCAATTGGACTCAGT
ATGGGCGCCTTAATTGCCATATTAGCATGCATCATTTTGCTGTTAGTCATCGTGGTGCTG
TTTGTAACTCTACGGCGGCATAAAAATGAACCATTAATTATCAAAGATGATGAAGACGTT
CGAGAAAACATCATTCGCTACGATGATGAAGGAGGAGGGGAGGAGGACACAGAGGCTTTT
GACATTGCAACTTTACAAAATCCAGATGGAATTAATGGATTTTTACCCCGTAAGGATATT
AAACCAGATTTGCAGTTTATGCCAAGGCAAGGGCTTGCTCCAGTTCCAAATGGTGTTGAT
GTCGATGAATTTATAAATGTAAGGCTGCATGAGGCAGATAATGATCCCACGGCCCCGCCA
TATGACTCCATTCAGATATATGGCTATGAAGGCCGAGGGTCAGTGGCTGGCTCCCTCAGC
TCCTTGGAGTCCACCACATCAGACTCAGACCAGAATTTTGACTACCTCAGTGACTGGGGT
CCCCGCTTTAAGAGACTGGGCGAACTCTACTCTGTTGGTGAAAGTGACAAAGAAACTTGA
Protein Properties
Number of Residues 799
Molecular Weight 88252.4
Theoretical pI 4.3
Pfam Domain Function
Signals
  • ["1-29"]
Transmembrane Regions
  • ["622-642"]
Protein Sequence
>Cadherin-8
MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSK
RGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHA
IKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMS
ILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEY
LVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA
NDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANV
HIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI
TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRV
PVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMV
NNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCS
NDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDV
RENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVD
VDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWG
PRFKRLGELYSVGESDKET
GenBank ID Protein 6483315
UniProtKB/Swiss-Prot ID P55286
UniProtKB/Swiss-Prot Entry Name CADH8_HUMAN
PDB IDs Not Available
GenBank Gene ID AB035305
GeneCard ID CDH8
GenAtlas ID CDH8
HGNC ID HGNC:1767
References
General References Not Available