| Identification |
|---|
| HMDB Protein ID
| CDBP02737 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-6 |
| Description
| Not Available |
| Synonyms
|
- K-cadherin
- Kidney cadherin
|
| Gene Name
| CDH6 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell-cell adhesion |
| homophilic cell adhesion |
| cell adhesion |
| cellular process |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5p13.3 |
| SNPs
| CDH6 |
| Gene Sequence
|
>2373 bp
ATGAGAACTTACCGCTACTTCTTGCTGCTCTTTTGGGTGGGCCAGCCCTACCCAACTCTC
TCAACTCCACTATCAAAGAGGACTAGTGGTTTCCCAGCAAAGAAAAGGGCCCTGGAGCTC
TCTGGAAACAGCAAAAATGAGCTGAACCGTTCAAAAAGGAGCTGGATGTGGAATCAGTTC
TTTCTCCTGGAGGAATACACAGGATCCGATTATCAGTATGTGGGCAAGTTACATTCAGAC
CAGGATAGAGGAGATGGATCACTTAAATATATCCTTTCAGGAGATGGAGCAGGAGATCTC
TTCATTATTAATGAAAACACAGGCGACATACAGGCCACCAAGAGGCTGGACAGGGAAGAA
AAACCCGTTTACATCCTTCGAGCTCAAGCTATAAACAGAAGGACAGGGAGACCCGTGGAG
CCCGAGTCTGAATTCATCATCAAGATCCATGACATCAATGACAATGAACCAATATTCACC
AAGGAGGTTTACACAGCCACTGTCCCTGAAATGTCTGATGTCGGTACATTTGTTGTCCAA
GTCACTGCGACGGATGCAGATGATCCAACATATGGGAACAGTGCTAAAGTTGTCTACAGT
ATTCTACAGGGACAGCCCTATTTTTCAGTTGAATCAGAAACAGGTATTATCAAGACAGCT
TTGCTCAACATGGATCGAGAAAACAGGGAGCAGTACCAAGTGGTGATTCAAGCCAAGGAT
ATGGGCGGCCAGATGGGAGGATTATCTGGGACCACCACCGTGAACATCACACTGACTGAT
GTCAACGACAACCCTCCCCGATTCCCCCAGAGTACATACCAGTTTAAAACTCCTGAATCT
TCTCCACCGGGGACACCAATTGGCAGAATCAAAGCCAGCGATGCTGATGTGGGAGAAAAT
GCTGAAATTGAGTACAGCATCACAGACGGTGAGGGGCTGGATATGTTTGATGTCATCACC
GACCAGGAAACCCAGGAAGGGATTATAACTGTCAAAAAGCTCTTGGACTTTGAAAAGAAG
AAAGTGTATACCCTTAAAGTGGAAGCCTCCAATCCTTATGTTGAGCCACGATTTCTCTAC
TTGGGGCCTTTCAAAGATTCAGCCACGGTTAGAATTGTGGTGGAGGATGTAGATGAGCCA
CCTGTCTTCAGCAAACTGGCCTACATCTTACAAATAAGAGAAGATGCTCAGATAAACACC
ACAATAGGCTCCGTCACAGCCCAAGATCCAGATGCTGCCAGGAATCCTGTCAAGTACTCT
GTAGATCGACACACAGATATGGACAGAATATTCAACATTGATTCTGGAAATGGTTCGATT
TTTACATCGAAACTTCTTGACCGAGAAACACTGCTATGGCACAACATTACAGTGATAGCA
ACAGAGATCAATAATCCAAAGCAAAGTAGTCGAGTACCTCTATATATTAAAGTTCTAGAT
GTCAATGACAACGCCCCAGAATTTGCTGAGTTCTATGAAACTTTTGTCTGTGAAAAAGCA
AAGGCAGATCAGTTGATTCAGACCTTGCATGCTGTTGACAAGGATGACCCTTATAGTGGG
CACCAATTTTCGTTTTCCTTGGCCCCTGAAGCAGCCAGTGGCTCAAACTTTACCATTCAA
GACAACAAAGACAACACGGCGGGAATCTTAACTCGGAAAAATGGCTATAATAGACACGAG
ATGAGCACCTATCTCTTGCCTGTGGTCATTTCAGACAACGACTACCCAGTTCAAAGCAGC
ACTGGGACAGTGACTGTCCGGGTCTGTGCATGTGACCACCACGGGAACATGCAATCCTGC
CACGCGGAGGCGCTCATCCACCCCACGGGACTGAGCACGGGGGCTCTGGTTGCCATCCTT
CTGTGCATCGTGATCCTACTAGTGACAGTGGTGCTGTTTGCAGCTCTGAGGCGGCAGCGA
AAAAAAGAGCCTTTGATCATTTCCAAAGAGGACATCAGAGATAACATTGTCAGTTACAAC
GACGAAGGTGGTGGAGAGGAGGACACCCAGGCTTTTGATATCGGCACCCTGAGGAATCCT
GAAGCCATAGAGGACAACAAATTACGAAGGGACATTGTGCCCGAAGCCCTTTTCCTACCC
CGACGGACTCCAACAGCTCGCGACAACACCGATGTCAGAGATTTCATTAACCAAAGGTTA
AAGGAAAATGACACGGACCCCACTGCCCCGCCATACGACTCCTTGGCCACTTACGCCTAT
GAAGGCACTGGCTCCGTGGCGGATTCCCTGAGCTCGCTGGAGTCAGTGACCACGGATGCA
GATCAAGACTATGATTACCTTAGTGACTGGGGACCTCGATTCAAAAAGCTTGCAGATATG
TATGGAGGAGTGGACAGTGACAAAGACTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 790 |
| Molecular Weight
| 88307.8 |
| Theoretical pI
| 4.53 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-6
MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF
FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE
KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ
VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD
MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN
AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY
LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS
VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD
VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ
DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC
HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN
DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRL
KENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM
YGGVDSDKDS
|
| External Links |
|---|
| GenBank ID Protein
| 158256016 |
| UniProtKB/Swiss-Prot ID
| P55285 |
| UniProtKB/Swiss-Prot Entry Name
| CADH6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK291290 |
| GeneCard ID
| CDH6 |
| GenAtlas ID
| CDH6 |
| HGNC ID
| HGNC:1765 |
| References |
|---|
| General References
| Not Available |