Identification |
HMDB Protein ID
| CDBP02736 |
Secondary Accession Numbers
| Not Available |
Name
| Cadherin-5 |
Description
| Not Available |
Synonyms
|
- 7B4 antigen
- CD144 antigen
- VE-cadherin
- Vascular endothelial cadherin
|
Gene Name
| CDH5 |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in calcium ion binding |
Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton |
GO Classification
|
Component |
membrane |
cell part |
plasma membrane |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
calcium ion binding |
Process |
cell adhesion |
cellular process |
cell-cell adhesion |
homophilic cell adhesion |
|
Cellular Location
|
- Cell membrane
- Cell junction
- Single-pass type I membrane protein (Probable)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 16q22.1 |
SNPs
| CDH5 |
Gene Sequence
|
>2355 bp
ATGCAGAGGCTCATGATGCTCCTCGCCACATCGGGCGCCTGCCTGGGCCTGCTGGCAGTG
GCAGCAGTGGCAGCAGCAGGTGCTAACCCTGCCCAACGGGACACCCACAGCCTGCTGCCC
ACCCACCGGCGCCAAAAGAGAGATTGGATTTGGAACCAGATGCACATTGATGAAGAGAAA
AACACCTCACTTCCCCATCATGTAGGCAAGATCAAGTCAAGCGTGAGTCGCAAGAATGCC
AAGTACCTGCTCAAAGGAGAATATGTGGGCAAGGTCTTCCGGGTCGATGCAGAGACAGGA
GACGTGTTCGCCATTGAGAGGCTGGACCGGGAGAATATCTCAGAGTACCACCTCACTGCT
GTCATTGTGGACAAGGACACTGGTGAAAACCTGGAGACTCCTTCCAGCTTCACCATCAAA
GTTCATGACGTGAACGACAACTGGCCTGTGTTCACGCATCGGTTGTTCAATGCGTCCGTG
CCTGAGTCGTCGGCTGTGGGGACCTCAGTCATCTCTGTGACAGCAGTGGATGCAGACGAC
CCCACTGTGGGAGACCACGCCTCTGTCATGTACCAAATCCTGAAGGGGAAAGAGTATTTT
GCCATCGATAATTCTGGACGTATTATCACAATAACGAAAAGCTTGGACCGAGAGAAGCAG
GCCAGGTATGAGATCGTGGTGGAAGCGCGAGATGCCCAGGGCCTCCGGGGGGACTCGGGC
ACGGCCACCGTGCTGGTCACTCTGCAAGACATCAATGACAACTTCCCCTTCTTCACCCAG
ACCAAGTACACATTTGTCGTGCCTGAAGACACCCGTGTGGGCACCTCTGTGGGCTCTCTG
TTTGTTGAGGACCCAGATGAGCCCCAGAACCGGATGACCAAGTACAGCATCTTGCGGGGC
GACTACCAGGACGCTTTCACCATTGAGACAAACCCCGCCCACAACGAGGGCATCATCAAG
CCCATGAAGCCTCTGGATTATGAATACATCCAGCAATACAGCTTCATCGTCGAGGCCACA
GACCCCACCATCGACCTCCGATACATGAGCCCTCCCGCGGGAAACAGAGCCCAGGTCATT
ATCAACATCACAGATGTGGACGAGCCCCCCATTTTCCAGCAGCCTTTCTACCACTTCCAG
CTGAAGGAAAACCAGAAGAAGCCTCTGATTGGCACAGTGCTGGCCATGGACCCTGATGCG
GCTAGGCATAGCATTGGATACTCCATCCGCAGGACCAGTGACAAGGGCCAGTTCTTCCGA
GTCACAAAAAAGGGGGACATTTACAATGAGAAAGAACTGGACAGAGAAGTCTACCCCTGG
TATAACCTGACTGTGGAGGCCAAAGAACTGGATTCCACTGGAACCCCCACAGGAAAAGAA
TCCATTGTGCAAGTCCACATTGAAGTTTTGGATGAGAATGACAATGCCCCGGAGTTTGCC
AAGCCCTACCAGCCCAAAGTGTGTGAGAACGCTGTCCATGGCCAGCTGGTCCTGCAGATC
TCCGCAATAGACAAGGACATAACACCACGAAACGTGAAGTTCAAATTCACCTTGAATACT
GAGAACAACTTTACCCTCACGGATAATCACGATAACACGGCCAACATCACAGTCAAGTAT
GGGCAGTTTGACCGGGAGCATACCAAGGTCCACTTCCTACCCGTGGTCATCTCAGACAAT
GGGATGCCAAGTCGCACGGGCACCAGCACGCTGACCGTGGCCGTGTGCAAGTGCAACGAG
CAGGGCGAGTTCACCTTCTGCGAGGATATGGCCGCCCAGGTGGGCGTGAGCATCCAGGCA
GTGGTAGCCATCTTACTCTGCATCCTCACCATCACAGTGATCACCCTGCTCATCTTCCTG
CGGCGGCGGCTCCGGAAGCAGGCCCGCGCGCACGGCAAGAGCGTGCCGGAGATCCACGAG
CAGCTGGTCACCTACGACGAGGAGGGCGGCGGCGAGATGGACACCACCAGCTACGATGTG
TCGGTGCTCAACTCGGTGCGCCGCGGCGGGGCCAAGCCCCCGCGGCCCGCGCTGGACGCC
CGGCCTTCCCTCTATGCGCAGGTGCAGAAGCCACCGAGGCACGCGCCTGGGGCACACGGA
GGGCCCGGGGAGATGGCAGCCATGATCGAGGTGAAGAAGGACGAGGCGGACCACGACGGC
GACGGCCCCCCCTACGACACGCTGCACATCTACGGCTACGAGGGCTCCGAGTCCATAGCC
GAGTCCCTCAGCTCCCTGGGCACCGACTCATCCGACTCTGACGTGGATTACGACTTCCTT
AACGACTGGGGACCCAGGTTTAAGATGCTGGCTGAGCTGTACGGCTCGGACCCCCGGGAG
GAGCTGCTGTATTAG
|
Protein Properties |
Number of Residues
| 784 |
Molecular Weight
| 87515.7 |
Theoretical pI
| 5.07 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Cadherin-5
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEK
NTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA
VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD
PTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSG
TATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRG
DYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVI
INITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFR
VTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFA
KPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFTLNTENNFTLTDNHDNTANITVKY
GQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQA
VVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDV
SVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDG
DGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPRE
ELLY
|
External Links |
GenBank ID Protein
| 599834 |
UniProtKB/Swiss-Prot ID
| P33151 |
UniProtKB/Swiss-Prot Entry Name
| CADH5_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| X79981 |
GeneCard ID
| CDH5 |
GenAtlas ID
| CDH5 |
HGNC ID
| HGNC:1764 |
References |
General References
| Not Available |