| Identification |
|---|
| HMDB Protein ID
| CDBP02733 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-2 |
| Description
| Not Available |
| Synonyms
|
- CD325 antigen
- CDw325
- N-cadherin
- Neural cadherin
|
| Gene Name
| CDH2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in alpha-catenin binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| plasma membrane |
| intrinsic to membrane |
| integral to membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell-cell adhesion |
| homophilic cell adhesion |
| cell adhesion |
| cellular process |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q11.2 |
| SNPs
| CDH2 |
| Gene Sequence
|
>2721 bp
ATGTGCCGGATAGCGGGAGCGCTGCGGACCCTGCTGCCGCTGCTGGCGGCCCTGCTTCAG
GCGTCTGTAGAGGCTTCTGGTGAAATCGCATTATGCAAGACTGGATTTCCTGAAGATGTT
TACAGTGCAGTCTTATCGAAGGATGTGCATGAAGGACAGCCTCTTCTCAATGTGAAGTTT
AGCAACTGCAATGGAAAAAGAAAAGTACAATATGAGAGCAGTGAGCCTGCAGATTTTAAG
GTGGATGAAGATGGCATGGTGTATGCCGTGAGAAGCTTTCCACTCTCTTCTGAACATGCC
AAGTTCCTGATATATGCCCAAGACAAAGAGACCCAGGAAAAGTGGCAAGTGGCAGTAAAA
TTGAGCCTGAAGCCAACCTTAACTGAGGAGTCAGTGAAGGAGTCAGCAGAAGTTGAAGAA
ATAGTGTTCCCAAGACAATTCAGTAAGCACAGTGGCCACCTACAAAGGCAGAAGAGAGAC
TGGGTCATCTCTCCAATCAACTTGCCAGAAAACTCCAGGGGACCTTTTCCTCAAGAGCTT
GTCAGGATCAGGTCTGATAGAGATAAAAACCTTTCACTGCGGTACAGTGTAACTGGGCCA
GGAGCTGACCAGCCTCCAACTGGTATCTTCATTATCAACCCCATCTCGGGTCAGCTGTCG
GTGACAAAGCCCCTGGATCGCGAGCAGATAGCCCGGTTTCATTTGAGGGCACATGCAGTA
GATATTAATGGAAATCAAGTGGAGAACCCCATTGACATTGTCATCAATGTTATTGACATG
AATGACAACAGACCTGAGTTCTTACACCAGGTTTGGAATGGGACAGTTCCTGAGGGATCA
AAGCCTGGAACATATGTGATGACCGTAACAGCAATTGATGCTGACGATCCCAATGCCCTC
AATGGGATGTTGAGGTACAGAATCGTGTCTCAGGCTCCAAGCACCCCTTCACCCAACATG
TTTACAATCAACAATGAGACTGGTGACATCATCACAGTGGCAGCTGGACTTGATCGAGAA
AAAGTGCAACAGTATACGTTAATAATTCAAGCTACAGACATGGAAGGCAATCCCACATAT
GGCCTTTCAAACACAGCCACGGCCGTCATCACAGTGACAGATGTCAATGACAATCCTCCA
GAGTTTACTGCCATGACGTTTTATGGTGAAGTTCCTGAGAACAGGGTAGACATCATAGTA
GCTAATCTAACTGTGACCGATAAGGATCAACCCCATACACCAGCCTGGAACGCAGTGTAC
AGAATCAGTGGCGGAGATCCTACTGGACGGTTCGCCATCCAGACCGACCAAAACAGCAAC
GACGGGTTAGTCACCGTGGTCAAACCAATCGACTTTGAAGCAAATAGGATGTTTGTCCTT
ACTGTTGCTGCAGAAAATCAAGTGCCATTAGCCAAGGGAATTCAGCACCCGCCTCAGTCA
ACTGCAACCATGTCTGTTACAGTTATTGACGTAAATGAAAACCCTTATTTTGCCCCCAAT
CCTAAGATCATTCGCCAAGAAGAAGGGCTTCATGCCGGTACCATGTTGACAACATTCACT
GCTCAGGACCCAGATCGATATATGCAGCAAAATATTAGATACACTAAATTATCTGATCCT
GCCAATTGGCTAAAAATAGATCCTGTGAATGGACAAATAACTACAATTGCTGTTTTGGAC
CGAGAATCACCAAATGTGAAAAACAATATATATAATGCTACTTTCCTTGCTTCTGACAAT
GGAATTCCTCCTATGAGTGGAACAGGAACGCTGCAGATCTATTTACTTGATATTAATGAC
AATGCCCCTCAAGTGTTACCTCAAGAGGCAGAGACTTGCGAAACTCCAGACCCCAATTCA
ATTAATATTACAGCACTTGATTATGGCATTGATCCAAATGCTGGACCATTTGCTTTTGAT
CTTCCTTTATCTCCAGTGACTATTAAGAGAAATTGGACCATCACTCGGCTTAATGGTGAT
TTTGCTCAGCTTAATTTAAAGATAAAATTTCTTGAAGCTGGTATCTATGAAGTTCCCATC
ATAATCACAGATTCGGGTAATCCTCCCAAATCAAATATTTCCATACTGCGCGTGAAGGTT
TGCCAGTGTGACTCCAACGGGGACTGCACAGATGTGGACAGGATTGTGGGTGCGGGGCTT
GGCACCGGTGCCATCATTGCCATCCTGCTCTGCATCATCATCCTGCTTATCCTTGTGCTG
ATGTTTGTGGTATGGATGAAACGCCGGGATAAAGAACGCCAGGCCAAACAACTTTTAATT
GATCCAGAAGATGATGTAAGAGATAATATTTTAAAATATGATGAAGAAGGTGGAGGAGAA
GAAGACCAGGACTATGACTTGAGCCAGCTGCAGCAGCCTGACACTGTGGAGCCTGATGCC
ATCAAGCCTGTGGGAATCCGACGAATGGATGAAAGACCCATCCACGCTGAGCCCCAGTAT
CCGGTCCGATCTGCAGCCCCACACCCTGGAGACATTGGGGACTTCATTAATGAGGGCCTT
AAAGCGGCTGACAATGACCCCACAGCTCCACCATATGACTCCCTGTTAGTGTTTGACTAT
GAAGGCAGTGGCTCCACTGCTGGGTCCTTGAGCTCCCTTAATTCCTCAAGTAGTGGTGGT
GAGCAGGACTATGATTACCTGAACGACTGGGGGCCACGGTTCAAGAAACTTGCTGACATG
TATGGTGGAGGTGATGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 906 |
| Molecular Weight
| 99808.4 |
| Theoretical pI
| 4.4 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-2
MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKF
SNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVK
LSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQEL
VRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAV
DINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNAL
NGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTY
GLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVY
RISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQS
TATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDP
ANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDIND
NAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGD
FAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGL
GTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGE
EDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGL
KAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADM
YGGGDD
|
| External Links |
|---|
| GenBank ID Protein
| 22209070 |
| UniProtKB/Swiss-Prot ID
| P19022 |
| UniProtKB/Swiss-Prot Entry Name
| CADH2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC036470 |
| GeneCard ID
| CDH2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |