| Identification |
|---|
| HMDB Protein ID
| CDBP02728 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-22 |
| Description
| Not Available |
| Synonyms
|
- PB-cadherin
- Pituitary and brain cadherin
|
| Gene Name
| CDH22 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q13.1 |
| SNPs
| CDH22 |
| Gene Sequence
|
>2487 bp
ATGAGGCCGAGGCCCGAAGGTAGGGGGCTCCGGGCGGGAGTCGCGCTGTCCCCCGCGCTA
CTGCTGCTGCTGCTGCTGCCGCCGCCGCCGACGCTGCTGGGGCGCCTGTGGGCAGCGGGC
ACACCCTCGCCGTCGGCGCCCGGAGCTCGGCAGGACGGCGCGCTGGGAGCCGGCCGCGTC
AAACGCGGCTGGGTGTGGAACCAGTTCTTCGTGGTAGAGGAGTACACGGGCACGGAGCCC
CTGTATGTGGGCAAGATCCACTCCGACTCAGACGAGGGTGACGGGGCCATCAAGTACACC
ATCTCAGGCGAGGGTGCTGGGACCATCTTCCTGATCGACGAGCTGACAGGCGACATTCAT
GCCATGGAGCGCCTGGACCGCGAGCAGAAAACCTTCTACACGCTGCGGGCCCAGGCTCGG
GATCGCGCCACCAACCGCCTACTGGAGCCCGAGTCGGAGTTCATCATCAAGGTGCAGGAC
ATCAATGACAGTGAGCCCCGCTTCCTGCACGGCCCCTATATTGGCAGCGTGGCCGAGCTC
TCACCTACAGGCACGTCGGTGATGCAGGTGATGGCCTCGGATGCGGATGACCCCACGTAC
GGCAGCAGCGCTCGGCTGGTGTACAGCGTGCTGGACGGCGAGCACCACTTCACCGTGGAC
CCCAAGACCGGCGTAATCCGGACGGCTGTGCCTGACCTTGACCGCGAGAGCCAGGAGCGC
TACGAGGTGGTGATCCAGGCCACAGACATGGCGGGTCAGCTGGGTGGCCTCTCGGGCTCC
ACTACCGTCACCATCGTAGTCACCGACGTCAATGACAACCCGCCCCGTTTCCCGCAGAAG
ATGTACCAGTTCAGCATCCAGGAGTCAGCCCCCATTGGAACGGCTGTGGGACGTGTGAAG
GCTGAGGACTCAGACGTGGGAGAGAACACAGACATGACTTACCACCTTAAGGACGAGAGC
AGCAGCGGCGGCGATGTGTTCAAGGTCACCACAGACAGCGACACTCAGGAGGCCATCATC
GTAGTGCAGAAGCGCCTGGACTTCGAATCCCAGCCCGTGCACACCGTGATCCTGGAGGCC
CTCAACAAGTTCGTGGACCCCCGCTTCGCCGACCTGGGCACGTTCCGCGACCAGGCGATC
GTGCGCGTGGCCGTGACCGACGTGGACGAGCCCCCCGAGTTCCGGCCGCCCTCCGGCCTC
CTGGAGGTGCAGGAGGACGCGCAGGTGGGCTCCCTGGTCGGCGTGGTGACGGCGCGGGAC
CCCGACGCCGCCAACCGGCCCGTCCGGTACGCCATTGACCGCGAATCAGATTTGGACCAG
ATCTTCGATATCGATGCGGACACAGGCGCCATCGTGACTGGCAAGGGGCTGGACCGCGAG
ACGGCCGGCTGGCACAACATCACAGTGCTGGCCATGGAGGCGGACAATCATGCACAGCTA
TCCCGGGCATCCCTAAGGATCCGAATCCTGGATGTGAACGACAATCCCCCAGAACTGGCC
ACACCCTACGAGGCAGCTGTATGCGAGGATGCCAAGCCAGGCCAGCTCATCCAGACCATC
AGCGTGGTGGACAGAGACGAGCCCCAAGGCGGGCACCGCTTCTATTTCCGCCTGGTGCCT
GAAGCTCCCAGCAACCCTCATTTCTCTCTGCTTGACATCCAAGACAACACCGCTGCAGTG
CACACGCAGCACGTGGGCTTCAACCGGCAGGAGCAGGACGTGTTCTTCCTGCCCATCCTG
GTGGTAGACAGTGGGCCGCCCACACTGAGCAGCACAGGCACGCTCACCATCCGCATCTGT
GGCTGCGACAGCTCCGGCACCATCCAGTCCTGCAACACCACGGCCTTTGTCATGGCCGCC
TCCCTCAGCCCCGGCGCCCTCATCGCCCTCTTGGTCTGCGTTCTCATCCTGGTTGTGCTG
GTGCTGCTGATCCTCACCCTCAGGCGCCACCACAAGAGCCACCTGAGCTCGGACGAGGAT
GAAGACATGCGGGACAACGTCATCAAATACAACGACGAAGGCGGCGGCGAGCAGGACACC
GAAGCCTACGACATGTCGGCGCTGCGGAGCCTCTACGACTTCGGCGAGCTCAAGGGCGGC
GACGGGGGCGGCAGCGCGGGCGGGGGAGCGGGCGGGGGCTCGGGCGGGGGCGCGGGCAGC
CCCCCGCAGGCCCACCTGCCCTCCGAGCGCCACTCGCTGCCGCAGGGGCCGCCGAGCCCC
GAGCCAGACTTCTCAGTGTTCAGGGACTTCATCAGCCGCAAGGTGGCACTGGCGGACGGG
GACCTGTCGGTGCCGCCCTACGACGCCTTCCAGACCTACGCCTTCGAGGGCGCGGACTCG
CCGGCCGCCTCGCTCAGCTCCCTGCACAGCGGCTCGTCGGGCTCCGAGCAGGACTTCGCC
TATCTCAGCAGCTGGGGTCCGCGCTTCCGGCCCCTGGCCGCGCTCTACGCCGGCCACCGC
GGGGACGACGAGGCCCAGGCCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 828 |
| Molecular Weight
| 89090.3 |
| Theoretical pI
| 4.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-22
MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRV
KRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIH
AMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAEL
SPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQER
YEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVK
AEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEA
LNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARD
PDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL
SRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVP
EAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC
GCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED
EDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGS
PPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADS
PAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS
|
| External Links |
|---|
| GenBank ID Protein
| 16753221 |
| UniProtKB/Swiss-Prot ID
| Q9UJ99 |
| UniProtKB/Swiss-Prot Entry Name
| CAD22_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_021248.1 |
| GeneCard ID
| CDH22 |
| GenAtlas ID
| CDH22 |
| HGNC ID
| HGNC:13251 |
| References |
|---|
| General References
| Not Available |