| Identification |
|---|
| HMDB Protein ID
| CDBP02724 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-17 |
| Description
| Not Available |
| Synonyms
|
- Intestinal peptide-associated transporter HPT-1
- LI-cadherin
- Liver-intestine cadherin
|
| Gene Name
| CDH17 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| homophilic cell adhesion |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q22.1 |
| SNPs
| CDH17 |
| Gene Sequence
|
>2499 bp
ATGATACTTCAGGCCCATCTTCACTCCCTGTGTCTTCTTATGCTTTATTTGGCAACTGGA
TATGGCCAAGAGGGGAAGTTTAGTGGACCCCTGAAACCCATGACATTTTCTATTTATGAA
GGCCAAGAACCGAGTCAAATTATATTCCAGTTTAAGGCCAATCCTCCTGCTGTGACTTTT
GAACTAACTGGGGAGACAGACAACATATTTGTGATAGAACGGGAGGGACTTCTGTATTAC
AACAGAGCCTTGGACAGGGAAACAAGATCTACTCACAATCTCCAGGTTGCAGCCCTGGAC
GCTAATGGAATTATAGTGGAGGGTCCAGTCCCTATCACCATAAAAGTGAAGGACATCAAC
GACAATCGACCCACGTTTCTCCAGTCAAAGTACGAAGGCTCAGTAAGGCAGAACTCTCGC
CCAGGAAAGCCCTTCTTGTATGTCAATGCCACAGACCTGGATGATCCGGCCACTCCCAAT
GGCCAGCTTTATTACCAGATTGTCATCCAGCTTCCCATGATCAACAATGTCATGTACTTT
CAGATCAACAACAAAACGGGAGCCATCTCTCTTACCCGAGAGGGATCTCAGGAATTGAAT
CCTGCTAAGAATCCTTCCTATAATCTGGTGATCTCAGTGAAGGACATGGGAGGCCAGAGT
GAGAATTCCTTCAGTGATACCACATCTGTGGATATCATAGTGACAGAGAATATTTGGAAA
GCACCAAAACCTGTGGAGATGGTGGAAAACTCAACTGATCCTCACCCCATCAAAATCACT
CAGGTGCGGTGGAATGATCCCGGTGCACAATATTCCTTAGTTGACAAAGAGAAGCTGCCA
AGATTCCCATTTTCAATTGACCAGGAAGGAGATATTTACGTGACTCAGCCCTTGGACCGA
GAAGAAAAGGATGCATATGTTTTTTATGCAGTTGCAAAGGATGAGTACGGAAAACCACTT
TCATATCCGCTGGAAATTCATGTAAAAGTTAAAGATATTAATGATAATCCACCTACATGT
CCGTCACCAGTAACCGTATTTGAGGTCCAGGAGAATGAACGACTGGGTAACAGTATCGGG
ACCCTTACTGCACATGACAGGGATGAAGAAAATACTGCCAACAGTTTTCTAAACTACAGG
ATTGTGGAGCAAACTCCCAAACTTCCCATGGATGGACTCTTCCTAATCCAAACCTATGCT
GGAATGTTACAGTTAGCTAAACAGTCCTTGAAGAAGCAAGATACTCCTCAGTACAACTTA
ACGATAGAGGTGTCTGACAAAGATTTCAAGACCCTTTGTTTTGTGCAAATCAACGTTATT
GATATCAATGATCAGATCCCCATCTTTGAAAAATCAGATTATGGAAACCTGACTCTTGCT
GAAGACACAAACATTGGGTCCACCATCTTAACCATCCAGGCCACTGATGCTGATGAGCCA
TTTACTGGGAGTTCTAAAATTCTGTATCATATCATAAAGGGAGACAGTGAGGGACGCCTG
GGGGTTGACACAGATCCCCATACCAACACCGGATATGTCATAATTAAAAAGCCTCTTGAT
TTTGAAACAGCAGCTGTTTCCAACATTGTGTTCAAAGCAGAAAATCCTGAGCCTCTAGTG
TTTGGTGTGAAGTACAATGCAAGTTCTTTTGCCAAGTTCACGCTTATTGTGACAGATGTG
AATGAAGCACCTCAATTTTCCCAACACGTATTCCAAGCGAAAGTCAGTGAGGATGTAGCT
ATAGGCACTAAAGTGGGCAATGTGACTGCCAAGGATCCAGAAGGTCTGGACATAAGCTAT
TCACTGAGGGGAGACACAAGAGGTTGGCTTAAAATTGACCACGTGACTGGTGAGATCTTT
AGTGTGGCTCCATTGGACAGAGAAGCCGGAAGTCCATATCGGGTACAAGTGGTGGCCACA
GAAGTAGGGGGGTCTTCCTTGAGCTCTGTGTCAGAGTTCCACCTGATCCTTATGGATGTG
AATGACAACCCTCCCAGGCTAGCCAAGGACTACACGGGCTTGTTCTTCTGCCATCCCCTC
AGTGCACCTGGAAGTCTCATTTTCGAGGCTACTGATGATGATCAGCACTTATTTCGGGGT
CCCCATTTTACATTTTCCCTCGGCAGTGGAAGCTTACAAAACGACTGGGAAGTTTCCAAA
ATCAATGGTACTCATGCCCGACTGTCTACCAGGCACACAGAGTTTGAGGAGAGGGAGTAT
GTCGTCTTGATCCGCATCAATGATGGGGGTCGGCCACCCTTGGAAGGCATTGTTTCTTTA
CCAGTTACATTCTGCAGTTGTGTGGAAGGAAGTTGTTTCCGGCCAGCAGGTCACCAGACT
GGGATACCCACTGTGGGCATGGCAGTTGGTATACTGCTGACCACCCTTCTGGTGATTGGT
ATAATTTTAGCAGTTGTGTTTATCCGCATAAAGAAGGATAAAGGCAAAGATAATGTTGAA
AGTGCTCAAGCATCTGAAGTCAAACCTCTGAGAAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 832 |
| Molecular Weight
| 92218.6 |
| Theoretical pI
| 4.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-17
MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF
ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN
DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF
QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK
APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR
EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG
TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL
TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP
FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV
FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY
SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV
NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK
INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT
GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS
|
| External Links |
|---|
| GenBank ID Protein
| 221316595 |
| UniProtKB/Swiss-Prot ID
| Q12864 |
| UniProtKB/Swiss-Prot Entry Name
| CAD17_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001144663.1 |
| GeneCard ID
| CDH17 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |