| Identification |
|---|
| HMDB Protein ID
| CDBP02722 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-13 |
| Description
| Not Available |
| Synonyms
|
- H-cadherin
- Heart cadherin
- P105
- T-cad
- T-cadherin
- Truncated cadherin
|
| Gene Name
| CDH13 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| plasma membrane |
| intrinsic to membrane |
| integral to membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell-cell adhesion |
| homophilic cell adhesion |
| cell adhesion |
| cellular process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q23.3 |
| SNPs
| CDH13 |
| Gene Sequence
|
>2142 bp
ATGCAGCCGAGAACTCCGCTCGTTCTGTGCGTTCTCCTGTCCCAGGTGCTGCTGCTAACA
TCTGCAGAAGATTTGGACTGCACTCCTGGATTTCAGCAGAAAGTGTTCCATATCAATCAG
CCAGCTGAATTCATTGAGGACCAGTCAATTCTAAACTTGACCTTCAGTGACTGTAAGGGA
AACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGC
TTAGTTGCTCTGAGAAACATAACTGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACC
CCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCAGGGCTCC
TTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATT
GTGGTATCTCCCATTTTAATTCCAGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGC
AAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAAGGGAGTG
GATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACA
CGGACCTTGGACAGAGAAGTAATCGCTGTTTATCAACTATTTGTGGAGACCACTGATGTC
AATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCAGAATGAC
AACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACA
GGCACCACAGTGATGCGGATGACAGCCTTTGATGCAGATGACCCAGCCACCGATAATGCC
CTCCTGCGGTATAATATCCGTCAACAGACGCCTGACAAGCCATCTCCCAACATGTTCTAC
ATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAG
ACTCTGGAAAATCCCAAGTATGAACTGATCATCGAGGCTCAAGATATGGCTGGACTGGAT
GTTGGATTAACAGGCACGGCCACAGCCACGATCATGATCGATGACAAAAATGATCACTCA
CCAAAATTCACCAAGAAAGAGTTTCAAGCCACAGTCGAGGAAGGAGCTGTGGGAGTTATT
GTCAATTTGACAGTTGAAGATAAGGATGACCCCACCACAGGTGCATGGAGGGCTGCCTAC
ACCATCATCAACGGAAACCCCGGGCAGAGCTTTGAAATCCACACCAACCCTCAAACCAAC
GAAGGGATGCTTTCTGTTGTCAAACCATTGGACTATGAAATTTCTGCCTTCCACACCCTG
CTGATCAAAGTGGAAAATGAAGACCCACTCGTACCCGACGTCTCCTACGGCCCCAGCTCC
ACAGCCACCGTCCACATCACTGTCCTGGATGTCAACGAGGGCCCAGTCTTCTACCCAGAC
CCCATGATGGTGACCAGGCAGGAGGACCTCTCTGTGGGCAGCGTGCTGCTGACAGTGAAT
GCCACGGACCCCGACTCCCTGCAGCATCAAACCATCAGGTATTCTGTTTACAAGGACCCA
GCAGGTTGGCTGAATATTAACCCCATCAATGGGACTGTTGACACCACAGCTGTGCTGGAC
CGTGAGTCCCCATTTGTCGACAACAGCGTGTACACTGCTCTCTTCCTGGCAATTGACAGT
GGCAACCCTCCCGCTACGGGCACTGGGACTTTGCTGATAACCCTGGAGGACGTGAATGAC
AATGCCCCGTTCATTTACCCCACAGTAGCTGAAGTCTGTGATGATGCCAAAAACCTCAGT
GTAGTCATTTTGGGAGCATCAGATAAGGATCTTCACCCGAATACAGATCCTTTCAAATTT
GAAATCCACAAACAAGCTGTTCCTGATAAAGTCTGGAAGATCTCCAAGATCAACAATACA
CACGCCCTGGTAAGCCTTCTTCAAAATCTGAACAAAGCAAACTACAACCTGCCCATCATG
GTGACAGATTCAGGGAAACCACCCATGACGAATATCACAGATCTCAGGGTACAAGTGTGC
TCCTGCAGGAATTCCAAAGTGGACTGCAACGCGGCGGGGGCCCTGCGCTTCAGCCTGCCC
TCAGTCCTGCTCCTCAGCCTCTTCAGCTTAGCTTGTCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 713 |
| Molecular Weight
| 78286.2 |
| Theoretical pI
| 4.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-13
MQPRTPLVLCVLLSQVLLLTSAEDLDCTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKG
NDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGV
DQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND
NRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY
IDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHS
PKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTN
EGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPD
PMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLD
RESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLS
VVILGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIM
VTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVLLLSLFSLACL
|
| External Links |
|---|
| GenBank ID Protein
| 3434957 |
| UniProtKB/Swiss-Prot ID
| P55290 |
| UniProtKB/Swiss-Prot Entry Name
| CAD13_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB001103 |
| GeneCard ID
| CDH13 |
| GenAtlas ID
| CDH13 |
| HGNC ID
| HGNC:1753 |
| References |
|---|
| General References
| Not Available |