| Identification |
|---|
| HMDB Protein ID
| CDBP02698 |
| Secondary Accession Numbers
| Not Available |
| Name
| C5a anaphylatoxin chemotactic receptor |
| Description
| Not Available |
| Synonyms
|
- C5a-R
- C5aR
- CD88 antigen
|
| Gene Name
| C5AR1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| anaphylatoxin receptor activity |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| c5a anaphylatoxin receptor activity |
| Process |
| response to stimulus |
| response to chemical stimulus |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| chemotaxis |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.3-q13.4 |
| SNPs
| C5AR1 |
| Gene Sequence
|
>1053 bp
ATGAACTCCTTCAATTATACCACCCCTGATTATGGGCACTATGATGACAAGGATACCCTG
GACCTCAACACCCCTGTGGATAAAACTTCTAACACGCTGCGTGTTCCAGACATCCTGGCC
TTGGTCATCTTTGCAGTCGTCTTCCTGGTGGGAGTGCTGGGCAATGCCCTGGTGGTCTGG
GTGACGGCATTCGAGGCCAAGCGGACCATCAATGCCATCTGGTTCCTCAACTTGGCGGTA
GCCGACTTCCTCTCCTGCCTGGCGCTGCCCATCTTGTTCACGTCCATTGTACAGCATCAC
CACTGGCCCTTTGGCGGGGCCGCCTGCAGCATCCTGCCCTCCCTCATCCTGCTCAACATG
TACGCCAGCATCCTGCTCCTGGCCACCATCAGCGCCGACCGCTTTCTGCTGGTGTTTAAA
CCCATCTGGTGCCAGAACTTCCGAGGGGCCGGCTTGGCCTGGATCGCCTGTGCCGTGGCT
TGGGGTTTAGCCCTGCTGCTGACCATACCCTCCTTCCTGTACCGGGTGGTCCGGGAGGAG
TACTTTCCACCAAAGGTGTTGTGTGGCGTGGACTACAGCCACGACAAACGGCGGGAGCGA
GCCGTGGCCATCGTCCGGCTGGTCCTGGGCTTCCTGTGGCCTCTACTCACGCTCACGATT
TGTTACACTTTCATCCTGCTCCGGACGTGGAGCCGCAGGGCCACGCGGTCCACCAAGACA
CTCAAGGTGGTGGTGGCAGTGGTGGCCAGTTTCTTTATCTTCTGGTTGCCCTACCAGGTG
ACGGGGATAATGATGTCCTTCCTGGAGCCATCGTCACCCACCTTCCTGCTGCTGAATAAG
CTGGACTCCCTGTGTGTCTCCTTTGCCTACATCAACTGCTGCATCAACCCCATCATCTAC
GTGGTGGCCGGCCAGGGCTTCCAGGGCCGACTGCGGAAATCCCTCCCCAGCCTCCTCCGG
AACGTGTTGACTGAAGAGTCCGTGGTTAGGGAGAGCAAGTCATTCACGCGCTCCACAGTG
GACACTATGGCCCAGAAGACCCAGGCAGTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 350 |
| Molecular Weight
| 39320.0 |
| Theoretical pI
| 9.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["38-60", "72-94", "111-132", "154-174", "201-226", "243-265", "283-303"]
|
| Protein Sequence
|
>C5a anaphylatoxin chemotactic receptor
MNSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLNKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
|
| External Links |
|---|
| GenBank ID Protein
| 4502509 |
| UniProtKB/Swiss-Prot ID
| P21730 |
| UniProtKB/Swiss-Prot Entry Name
| C5AR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001736.3 |
| GeneCard ID
| C5AR1 |
| GenAtlas ID
| C5AR1 |
| HGNC ID
| HGNC:1338 |
| References |
|---|
| General References
| Not Available |