Showing Protein Class A basic helix-loop-helix protein 15 (CDBP02685)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02685
Secondary Accession Numbers Not Available
Name Class A basic helix-loop-helix protein 15
Description Not Available
Synonyms
  1. Class B basic helix-loop-helix protein 8
  2. MIST-1
  3. Muscle, intestine and stomach expression 1
  4. bHLHa15
  5. bHLHb8
Gene Name BHLHA15
Protein Type Transcription Factor
Biological Properties
General Function Involved in transcription regulator activity
Specific Function Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
transcription regulator activity
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
Cellular Location
  1. Nucleus (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:7
Locus 7q21.3
SNPs BHLHA15
Gene Sequence 
>570 bp
ATGAAGACCAAGAACCGGCCCCCACGGCGCCGGGCCCCGGTGCAGGACACAGAGGCCACC
CCCGGGGAGGGGACGCCCGACGGGTCCCTGCCGAACCCGGGGCCAGAGCCGGCCAAGGGT
CTGCGGAGCCGGCCGGCCCGGGCCGCAGCAAGGGCTCCGGGCGAGGGCAGGCGCAGGCGG
CCAGGACCCTCCGGGCCCGGTGGCCGTCGTGACAGCAGCATCCAGCGGCGGCTGGAGAGC
AACGAGAGGGAGCGGCAGCGGATGCACAAGCTAAATAACGCCTTCCAGGCCCTGCGTGAA
GTCATCCCCCACGTGCGCGCGGACAAGAAGCTCTCCAAGATCGAGACGCTCACGCTGGCC
AAGAACTACATCAAATCGCTGACGGCCACCATCCTGACCATGTCCAGCAGCCGCCTCCCA
GGCCTGGAGGGGCCGGGCCCCAAGCTCTACCAGCACTACCAGCAGCAGCAGCAGGTGGCT
GGGGGTGCGTTGGGGGCCACGGAGGCCCAGCCCCAGGGCCACCTGCAGAGGTACTCCACG
CAGATCCACAGCTTCCGAGAGGGCACCTAG
Protein Properties
Number of Residues 189
Molecular Weight 20818.3
Theoretical pI 11.8
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Class A basic helix-loop-helix protein 15
MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRR
PGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLA
KNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYST
QIHSFREGT
GenBank ID Protein 29126247
UniProtKB/Swiss-Prot ID Q7RTS1
UniProtKB/Swiss-Prot Entry Name BHA15_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_177455.3
GeneCard ID BHLHA15
GenAtlas ID BHLHA15
HGNC ID HGNC:22265
References
General References Not Available