| Identification |
|---|
| HMDB Protein ID
| CDBP02674 |
| Secondary Accession Numbers
| Not Available |
| Name
| Arylsulfatase I |
| Description
| Not Available |
| Synonyms
|
- ASI
|
| Gene Name
| ARSI |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| sulfuric ester hydrolase activity |
| hydrolase activity, acting on ester bonds |
| Process |
| metabolic process |
|
| Cellular Location
|
- Secreted
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q32 |
| SNPs
| ARSI |
| Gene Sequence
|
>1710 bp
ATGCACACCCTCACTGGCTTCTCCCTGGTCAGCCTGCTCAGCTTCGGCTACCTGTCCTGG
GACTGGGCCAAGCCGAGCTTCGTGGCCGACGGGCCCGGGGAGGCTGGCGAGCAGCCCTCG
GCCGCTCCGCCCCAGCCTCCCCACATCATCTTCATCCTCACGGACGACCAAGGCTACCAC
GACGTGGGCTACCATGGTTCAGATATCGAGACCCCTACGCTGGACAGGCTGGCGGCCAAG
GGGGTCAAGTTGGAGAATTATTACATCCAGCCCATCTGCACGCCTTCGCGGAGCCAGCTC
CTCACTGGCAGGTACCAGATCCACACAGGACTCCAGCATTCCATCATCCGCCCACAGCAG
CCCAACTGCCTGCCCCTGGACCAGGTGACACTGCCACAGAAGCTGCAGGAGGCAGGTTAT
TCCACCCATATGGTGGGCAAGTGGCACCTGGGCTTCTACCGGAAGGAGTGTCTGCCCACC
CGTCGGGGCTTCGACACCTTCCTGGGCTCGCTCACGGGCAATGTGGACTATTACACCTAT
GACAACTGTGATGGCCCAGGCGTGTGCGGCTTCGACCTGCACGAGGGTGAGAATGTGGCC
TGGGGGCTCAGCGGCCAGTACTCCACTATGCTTTACGCCCAGCGCGCCAGCCATATCCTG
GCCAGCCACAGCCCTCAGCGTCCCCTCTTCCTCTATGTGGCCTTCCAGGCAGTACACACA
CCCCTGCAGTCCCCTCGTGAGTACCTGTACCGCTACCGCACCATGGGCAATGTGGCCCGG
CGGAAGTACGCGGCCATGGTGACCTGCATGGATGAGGCTGTGCGCAACATCACCTGGGCC
CTCAAGCGCTACGGTTTCTACAACAACAGTGTCATCATCTTCTCCAGTGACAATGGTGGC
CAGACTTTCTCGGGGGGCAGCAACTGGCCGCTCCGAGGACGCAAGGGCACTTATTGGGAA
GGTGGCGTGCGGGGCCTAGGCTTTGTCCACAGTCCCCTGCTCAAGCGAAAGCAACGGACA
AGCCGGGCACTGATGCACATCACTGACTGGTACCCGACCCTGGTGGGTCTGGCAGGTGGT
ACCACCTCAGCAGCCGATGGGCTAGATGGCTACGACGTGTGGCCGGCCATCAGCGAGGGC
CGGGCCTCACCACGCACGGAGATCCTGCACAACATTGACCCACTCTACAACCATGCCCAG
CATGGCTCCCTGGAGGGCGGCTTTGGCATCTGGAACACCGCCGTGCAGGCTGCCATCCGC
GTGGGTGAGTGGAAGCTGCTGACAGGAGACCCCGGCTATGGCGATTGGATCCCACCGCAG
ACACTGGCCACCTTCCCGGGTAGCTGGTGGAACCTGGAACGAATGGCCAGTGTCCGCCAG
GCCGTGTGGCTCTTCAACATCAGTGCTGACCCTTATGAACGGGAGGACCTGGCTGGCCAG
CGGCCTGATGTGGTCCGCACCCTGCTGGCTCGCCTGGCCGAATATAACCGCACAGCCATC
CCGGTACGCTACCCAGCTGAGAACCCCCGGGCTCATCCTGACTTTAATGGGGGTGCTTGG
GGGCCCTGGGCCAGTGATGAGGAAGAGGAGGAAGAGGAAGGGAGGGCTCGAAGCTTCTCC
CGGGGTCGTCGCAAGAAAAAATGCAAGATTTGCAAGCTTCGATCCTTTTTCCGTAAACTC
AACACCAGGCTAATGTCCCAACGGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 569 |
| Molecular Weight
| 64029.8 |
| Theoretical pI
| 8.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Arylsulfatase I
MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYH
DVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQ
PNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTY
DNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHT
PLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGG
QTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGG
TTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIR
VGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQ
RPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFS
RGRRKKKCKICKLRSFFRKLNTRLMSQRI
|
| External Links |
|---|
| GenBank ID Protein
| 220983388 |
| UniProtKB/Swiss-Prot ID
| Q5FYB1 |
| UniProtKB/Swiss-Prot Entry Name
| ARSI_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB448735 |
| GeneCard ID
| ARSI |
| GenAtlas ID
| ARSI |
| HGNC ID
| HGNC:32521 |
| References |
|---|
| General References
| Not Available |