| Identification |
|---|
| HMDB Protein ID
| CDBP02663 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ankyrin repeat and sterile alpha motif domain-containing protein 1B |
| Description
| Not Available |
| Synonyms
|
- AIDA-1
- Amyloid-beta protein intracellular domain-associated protein 1
- E2A-PBX1-associated protein
- EB-1
|
| Gene Name
| ANKS1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Isoform 6:Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q23.1 |
| SNPs
| ANKS1B |
| Gene Sequence
|
>3750 bp
ATGGGGAAGGACCAGGAGCTGCTGGAAGCTGCTCGCACTGGAAATGTGGCTCTGGTGGAG
AAACTCCTGTCTGGCAGGAAAGGAGGGATCCTGGGCGGTGGATCCGGACCCCTGCCCCTG
TCTAATCTGCTAAGCATCTGGCGAGGCCCCAATGTGAACTGCACAGACAGTTCGGGTTAC
ACTGCTTTACACCACGCAGCCTTAAATGGACATAAGGACATAGTTCTCAAACTACTTCAG
TATGAGGCATCAACAAATGTAGCAGACAACAAAGGGTATTTTCCTATTCACCTGGCTGCC
TGGAAAGGAGATGTGGAAATTGTGAAGATTCTTATTCATCATGGACCATCACATTCCAGG
GTCAATGAACAGAACAATGAAAATGAAACTGCCCTACACTGTGCAGCTCAATATGGACAC
TCAGAAGTAGTTGCTGTTCTCCTAGAAGAGCTCACTGACCCGACAATTAGAAATAGCAAG
CTGGAAACACCTTTGGACTTGGCGGCACTCTACGGACGGCTTAGAGTGGTAAAAATGATC
ATCAGTGCACATCCTAACTTAATGAGCTGCAACACTCGCAAGCACACGCCACTTCACCTT
GCTGCGCGCAATGGCCACAAAGCAGTCGTGCAGGTGCTGCTGGAGGCAGGAATGGATGTG
AGCTGTCAAACAGAAAAGGGGAGTGCACTTCATGAAGCAGCTTTGTTTGGAAAGGTGGAT
GTTGTACGAGTTCTGTTAGAAACAGGAATTGATGCCAACATAAAGGATAGCTTAGGTAGA
ACTGTCTTGGACATTCTGAAAGAACATCCATCTCAGAAATCTCTCCAGATTGCAACACTC
TTACAAGAGTATTTAGAAGGCGTGGGTAAGTATGCTACAGTCCTCGAAGAGCCTGTACAG
GAAGATGCAACACAAGAAACACACATTTCATCTCCTGTTGAGTCTCCTTCCCAAAAGACC
AAAAGTGAAACCGTCACTGGAGAATTATCAAAACTCTTGGATGAAATAAAACTCTGTCAA
GAAAAGGATTATTCGTTTGAAGACTTGTGCCACACAATATCAGACCACTACTTAGATAAT
TTGAGCAAGATTTCAGAGGAAGAACTTGGGAAAAATGGAAGCCAGAGTGTAAGAACCTCA
TCTACAATCAATTTGTCACCAGGAGAAGTGGAAGAAGAGGATGATGATGAAAATACGTGT
GGGCCATCAGGACTTTGGGAAGCATTAACTCCGTGTAATGGATGTAGGAACCTTGGCTTC
CCCATGCTTGCCCAGGAGTCCTATCCAAAGAAGAGAAATTACACTATGGAAATTGTACCA
TCTGCTTCTCTGGATACATTTCCTTCAGAAAATGAGAACTTTCTGTGTGATCTCATGGAC
ACAGCTGTTACAAAGAAACCTTGCTCCTTAGAAATTGCAAGGGCACCTTCCCCAAGAACT
GATAATGCCTCTGAGGTAGCAGTTACTACTCCAGGAACTAGTAACCATAGAAACAGCTCA
ACAGGCCCAACACCTGATTGTTCACCTCCATCCCCTGATACTGCCCTCAAAAATATTGTA
AAAGTCATTCGACCCCAGCCTAAACAGCGAACATCCATTGTGTCTTCTCTGGATTTTCAC
CGAATGAATCACAACCAAGAATATTTTGAAATCAACACATCTACAGGGTGCACAAGCTTT
ACTGCCAGTCCTCCTGCTAGTCCACCCACCTCTTCTGTGGGAACCACAGAAGTCAAGAAT
GAGGGAACTAACCATACAGATGACCTCTCCCGACAGGATGACAATGATCCCCCAAAAGAA
TATGATCCTGGGCAATTTGCAGGCCTGCTCCATGGATCCTCTCCAGCCTGTGAGTCCCCT
GAAAATCCATTTCATCTCTATGGGAAAAGAGAACAATGTGAAAAAGGACAAGATGAAGTC
AGTTTGGCAAACAGTCCTTTGCCTTTCAAGCAGTCTCCAATAGAAAATAACTCAGAACCT
TTGGTAAAGAAAATTAAACCCAAAGTGGTCAGTAGAACAATTTTTCACAAAAAAAGCAAC
CAACTCGAAAACCATACCATTGTTGGCACAAGATCAACCAGGAGTGGATCTCGGAATGGG
GACCAGTGGGTTATGAACGCAGGGGGATTTGTGGAGAGAGCCTGTACTCTGGGGAGAATA
AGGTCATTGCCTAAAGCCTTGATCGACATGCATTTGTCAAAAAGTGTCTCTAAATCTGAT
TCTGATCTCATTGCCTATCCTTCCAATGAGAAAACATCAAGAGTTAACTGGAGTGAATCT
TCCACTGCTGAACACAGTTCTAAAGGGAATTCTGAAAGAACACCATCCTTCACATCGGAA
TGGGAAGAAATTGACAAAATAATGAGTTCCATAGATGTTGGAATCAACAACGAACTTAAA
GAGATGAATGGTGAGACCACAAGACCCAGATGCCCTGTCCAAACAGTGGGACAATGGTTG
GAAAGCATTGGGCTACCTCAGTACGAGAACCACCTGATGGCTAATGGATTTGACAATGTG
CAGTTTATGGGAAGCAATGTTATGGAAGATCAGGATTTGTTGGAAATTGGAATCCTTAAT
TCTGGGCACAGACAAAGAATTCTACAGGCAATCCAGCTCCTTCCAAAGATGAGACCCATT
GGGCATGATGGCTACCATCCCACCTCTGTAGCTGAGTGGCTGGATTCCATTGAACTGGGC
GACTACACCAAAGCCTTTCTAATTAATGGCTACACTTCGATGGACCTGTTGAAAAAAATC
TGGGAGGTTGAACTTATTAATGTTTTAAAAATCAATTTGATTGGCCACAGGAAACGTATT
TTGGCATCTCTGGGAGACAGGCTGCACGACGATCCCCCACAGAAGCCCCCTCGGTCCATC
ACCCTCAGGGAACCCAGTGGTAATCACACTCCTCCTCAGTTGTCTCCATCACTTAGCCAA
AGCACTTACACCACTGGTGGCTCCCTAGACGTTCCTCACATTATCATGCAGGGCGATGCA
AGGAGGAGAAGAAATGAAAACTACTTTGATGATATTCCCCGATCAAAACTGGAGAGGCAG
ATGGCTCAGACAGGAGACTGGGGAGAACCTTCCATTACCTTGCGACCTCCGAATGAAGCC
ACAGCCTCTACCCCGGTACAGTACTGGCAGCATCACCCAGAAAAGCTTATCTTCCAGTCG
TGTGATTACAAAGCTTTTTATTTAGGTTCTATGCTGATAAAAGAGCTTAGGGGGACAGAA
TCAACCCAAGATGCTTGTGCAAAAATGCGGGCTAACTGTCAGAAGTCTACAGAGCAAATG
AAGAAGGTCCCTACTATTATTCTTTCTGTCTCATATAAAGGAGTCAAATTTATTGATGCA
ACAAATAAGAACATAATTGCTGAGCATGAAATTCGTAATATCTCCTGTGCTGCCCAGGAC
CCAGAAGACCTCTCAACATTTGCCTATATCACAAAAGATTTGAAGTCTAATCACCACTAC
TGTCATGTGTTTACTGCCTTTGATGTGAATTTAGCCTATGAAATCATCCTAACCCTGGGA
CAGGCATTCGAAGTCGCTTACCAGCTAGCACTACAAGCAAGAAAAGGGGGACACTCCTCC
ACACTTCCAGAAAGCTTTGAAAACAAACCCTCCAAACCCATCCCCAAGCCCCGCGTTAGC
ATTCGCAAGTCCGTGGATCTTCTTCATGCCAGCCATACCGGGCAGGAACCATCAGAGAGA
CACACTGAGGAGGCACTCAGAAAATTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1249 |
| Molecular Weight
| 138184.2 |
| Theoretical pI
| 6.33 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ankyrin repeat and sterile alpha motif domain-containing protein 1B
MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY
TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR
VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI
ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD
VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGKYATVLEEPVQ
EDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDN
LSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGF
PMLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRT
DNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFH
RMNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKE
YDPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEP
LVKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRI
RSLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSE
WEEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNV
QFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELG
DYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSI
TLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQ
MAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTE
STQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQD
PEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSS
TLPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF
|
| External Links |
|---|
| GenBank ID Protein
| 31746739 |
| UniProtKB/Swiss-Prot ID
| Q7Z6G8 |
| UniProtKB/Swiss-Prot Entry Name
| ANS1B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY281131 |
| GeneCard ID
| ANKS1B |
| GenAtlas ID
| ANKS1B |
| HGNC ID
| HGNC:24600 |
| References |
|---|
| General References
| Not Available |